Analysis of projects funded by NSFC in field of pharmacology of traditional Chinese medicine between 2010 to 2013 fiscal years / 中国中药杂志

Projects which supported by National Natural Science Foundation of China (NSFC) in discipline of pharmacology of Chinese medicine between 2010 to 2013 financial years were reviewed. Based on these research items, new features and problems were summarized in this field.

Applications and approved projectsof general program, young scientist fund and fund for less developedregion of national natural science funds in discipline of Chinese materia medica, NSFC in 2012 / 中国中药杂志

The applications accepted and approved by general program, young scientist fund and fund for less developed region of national natural science funds in the discipline of Chinese materia medica, NSFC in 2012 have been introduced. The research contents of the funded projects in the popular research areas have been summarized and the problems in the applications have been analyzed to give a reference to the scientists in the field of Chinese materia medica.

National Natural Science Foundation of China promotes the development of Chinese medicine in China--an analysis of Chinese medicine project funded by National Natural Science Foundation of China in the last decade / 中国中西医结合杂志

In recent years, projects funded by the Division V III of Health Sciences of the National Natural Science Foundation of China (NSFC) increased steadily, which enhanced the process of modernization of Chinese medicine (CM). We analyzed CM projects funded by NSFC during 2003 -2012, which aimed to provide reference to experts in the CM field.

Effect of active components of Chinese herbal medicine Xiaoxuming decoction on oxidative stress and neuronal apoptosis in rats with chronic cerebral ischemia / 中华神经医学杂志

Objective To investigate the effect of active components of Xiaoxuming decoction (XXM) on oxidative stress and neuronal apoptosis in rats with chronic cerebral ischemia.Methods Bilateral common carotid arteries were permanently occluded in rats to establish the chronic cerebral ischemia models.The rats with chronic cerebral ischemia were randomly divided into five groups:vehicle group,Ginkgo biloba extract (EGB) group,and low-,medium-and high-dose active components of XXM groups.The sham-operated rats were treated with saline.The activities of superoxide dismutase (SOD),glutathione peroxidase (GSH-Px),catalase and the malondialdehyde (MDA) content were detected with spectrophotometry.TUNEL assay was used to measure the neuronal apoptosis.Western blotting was used to observe the expressions of neuronal apoptosis related proteins such as Caspase-3,Bcl-2 and Bax.Results The low-dose and medium-dose active components of XXM could significantly inhibit oxidative stress,decrease lipid peroxide,and attenuate the decreased activities of GSH-Px in 2VO rats (P＜0.05).The medium-dose active components of XXM markedly prevented neurons from apoptosis (P＜0.05).In addition,the low-dose and medium-dose active components of XXM increased Bcl-2/Bax ratio and decreased Caspase-3 mediated downstream cascade reaction (P＜0.05).Conclusion The active components of XXM can inhibit oxidative stress and decrease neuronal apoptosis in rots with chronic cerebral ischemia.