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RATIONALE: Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce. PURPOSE: To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19. METHODS: This will be a multicenter case-control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance. RESULTS: The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes. CONCLUSION: This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population.
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COVID-19 , Hospitalización , Calidad de Vida , Síndrome de Dificultad Respiratoria , Humanos , COVID-19/complicaciones , COVID-19/epidemiología , Síndrome de Dificultad Respiratoria/fisiopatología , Brasil/epidemiología , Estudios de Casos y Controles , Pulmón/fisiopatología , Pulmón/diagnóstico por imagen , SARS-CoV-2 , Riñón/fisiopatología , Masculino , Femenino , Pruebas de Función Respiratoria , Capacidad de Difusión PulmonarRESUMEN
ABSTRACT Rationale: Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce. Purpose: To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19. Methods: This will be a multicenter case-control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance. Results: The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes. Conclusion: This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population.
RESUMO Fundamento: As evidências acerca das sequelas a longo prazo após internação por síndrome do desconforto respiratório agudo por COVID-19 ainda são escassas. Objetivo: Avaliar alterações nas funções pulmonar, cardíaca e renal e na qualidade de vida após internação por síndrome do desconforto respiratório agudo secundária à COVID-19. Métodos: Trata-se de estudo multicêntrico, caso-controle, incluindo 220 participantes. Os casos serão definidos como pacientes hospitalizados por síndrome do desconforto respiratório agudo devido à COVID-19. No Grupo Controle, serão selecionados indivíduos sem histórico de hospitalização nos últimos 12 meses ou sintomas a longo prazo de COVID-19. Todos os indivíduos serão submetidos à espirometria pulmonar com teste de difusão pelo monóxido de carbono, tomografia de tórax, ressonância magnética cardíaca e renal com gadolínio, ergoespirometria, creatinina sérica e urinária, proteínas totais e microalbuminúria urinária, além de questionários de qualidade de vida. Os casos serão avaliados 12 meses após a alta hospitalar e os controles, 90 dias após a inclusão no estudo. Para todas as análises estatísticas, será assumido como significativo o valor p < 0,05. Resultados: O desfecho primário do estudo foi definido com a capacidade de difusão pulmonar aferida para o monóxido de carbono a partir de 12 meses. Os demais parâmetros das funções pulmonar, cardíacas e renal e da qualidade de vida foram definidos como desfechos secundários. Conclusão: Este estudo visa determinar as sequelas a longo prazo nas funções pulmonar, cardíaca e renal e na qualidade de vida de pacientes internados por síndrome do desconforto respiratório agudo devido à COVID-19 na população brasileira.
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OBJECTIVE: To determine independent factors related to the use of oxygen and the oxygen flow rate in idiopathic pulmonary fibrosis (IPF) patients placed on a lung transplant waitlist and undergoing pulmonary rehabilitation (PR). METHODS: This was a retrospective quasi-experimental study presenting functional capacity and health-related quality of life (HRQoL) data from lung transplant candidates with IPF referred for PR and receiving ambulatory oxygen therapy. The patients were divided into three groups on the basis of the oxygen flow rate: 0 L/min (the control group), 1-3 L/min, and 4-5 L/min. Data on functional capacity were collected by means of the six-minute walk test, and data on HRQoL were collected by means of the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), being collected before and after 36 sessions of PR including aerobic and strength exercises. RESULTS: The six-minute walk distance improved in all three groups (0 L/min: Δ 61 m, p < 0.001; 1-3 L/min: Δ 58 m, p = 0.014; and 4-5 L/min: Δ 35 m, p = 0.031). Regarding HRQoL, SF-36 physical functioning domain scores improved in all three groups, and the groups of patients receiving ambulatory oxygen therapy had improvements in other SF-36 domains, including role-physical (1-3 L/min: p = 0.016; 4-5 L/min: p = 0.040), general health (4-5 L/min: p = 0.013), social functioning (1-3 L/min: p = 0.044), and mental health (1-3 L/min: p = 0.046). CONCLUSIONS: The use of ambulatory oxygen therapy during PR in lung transplant candidates with IPF and significant hypoxemia on exertion appears to improve functional capacity and HRQoL.
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Fibrosis Pulmonar Idiopática , Trasplante de Pulmón , Humanos , Calidad de Vida , Estudios Retrospectivos , Oxígeno , Tolerancia al EjercicioRESUMEN
ABSTRACT Objective: To determine independent factors related to the use of oxygen and the oxygen flow rate in idiopathic pulmonary fibrosis (IPF) patients placed on a lung transplant waitlist and undergoing pulmonary rehabilitation (PR). Methods: This was a retrospective quasi-experimental study presenting functional capacity and health-related quality of life (HRQoL) data from lung transplant candidates with IPF referred for PR and receiving ambulatory oxygen therapy. The patients were divided into three groups on the basis of the oxygen flow rate: 0 L/min (the control group), 1-3 L/min, and 4-5 L/min. Data on functional capacity were collected by means of the six-minute walk test, and data on HRQoL were collected by means of the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), being collected before and after 36 sessions of PR including aerobic and strength exercises. Results: The six-minute walk distance improved in all three groups (0 L/min: Δ 61 m, p < 0.001; 1-3 L/min: Δ 58 m, p = 0.014; and 4-5 L/min: Δ 35 m, p = 0.031). Regarding HRQoL, SF-36 physical functioning domain scores improved in all three groups, and the groups of patients receiving ambulatory oxygen therapy had improvements in other SF-36 domains, including role-physical (1-3 L/min: p = 0.016; 4-5 L/min: p = 0.040), general health (4-5 L/min: p = 0.013), social functioning (1-3 L/min: p = 0.044), and mental health (1-3 L/min: p = 0.046). Conclusions: The use of ambulatory oxygen therapy during PR in lung transplant candidates with IPF and significant hypoxemia on exertion appears to improve functional capacity and HRQoL.
RESUMO Objetivo: Determinar fatores independentes relacionados ao uso de oxigênio e ao fluxo de oxigênio em pacientes com fibrose pulmonar idiopática (FPI) em lista de espera para transplante de pulmão e em reabilitação pulmonar (RP). Métodos: Estudo quase experimental retrospectivo no qual são apresentados dados referentes à capacidade funcional e qualidade de vida relacionada à saúde (QVRS) de pacientes com FPI candidatos a transplante de pulmão e encaminhados para RP em oxigenoterapia ambulatorial. Os pacientes foram divididos em três grupos com base no fluxo de oxigênio: 0 L/min (grupo controle), 1-3 L/min e 4-5 L/min. Os dados referentes à capacidade funcional foram coletados por meio do teste de caminhada de seis minutos, e os dados referentes à QVRS foram coletados por meio do Medical Outcomes Study 36-item Short-Form Health Survey (SF-36), sendo coletados antes e depois de 36 sessões de RP com exercícios aeróbicos e de força. Resultados: A distância percorrida no teste de caminhada de seis minutos melhorou nos três grupos (0 L/min: Δ 61 m, p < 0,001; 1-3 L/min: Δ 58 m, p = 0,014; 4-5 L/min: Δ 35 m, p = 0,031). No tocante à QVRS, a pontuação obtida no domínio "capacidade funcional" do SF-36 melhorou nos três grupos, e os pacientes que receberam oxigenoterapia ambulatorial apresentaram melhora em outros domínios do SF-36: função física (1-3 L/min: p = 0,016; 4-5 L/min: p = 0,040), estado geral de saúde (4-5 L/min: p = 0,013), aspectos sociais (1-3 L/min: p = 0,044) e saúde mental (1-3 L /min: p = 0,046). Conclusões: O uso de oxigenoterapia ambulatorial durante a RP em candidatos a transplante de pulmão com FPI e hipoxemia significativa aos esforços parece melhorar a capacidade funcional e a QVRS.
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BACKGROUND: Pulmonary diseases represent a great cause of disability and mortality in the world, and given the progression of these pathologies, pulmonary rehabilitation programs have proven to be effective for people with chronic respiratory diseases. During the COVID-19 pandemic, telerehabilitation has become an alternative for patients with such diseases. OBJECTIVE: The aim of this study was to compare the outcomes (ie, functional capacity and quality of life) of telerehabilitation to those of usual care among patients who previously participated in face-to-face pulmonary rehabilitation programs. METHODS: We conducted a quasi-experimental retrospective study from April 2020 to August 2021. A total of 32 patients with chronic lung diseases were included and divided into the control and intervention groups. The intervention group performed telerehabilitation synchronously twice per week and was supervised by a physical therapist during breathing, strengthening, and aerobic exercises. Changes in the degree of dyspnea and leg discomfort were assessed based on changes in Borg scale scores. The control group did not perform any activities during the period of social isolation. Functional capacity was assessed with the 6-minute walk test, and quality of life was assessed with the Medical Outcomes Study 36-item Short Form Health Survey. RESULTS: The telerehabilitation group's mean 6-minute walk distance decreased by 39 m, while that of the control group decreased by 120 m. There was a difference of 81 m between the groups' mean 6-minute walk distances (P=.02). In relation to the quality of life, telerehabilitation was shown to improve the following two domains: social functioning and mental health. CONCLUSIONS: Telerehabilitation programs for patients with chronic lung diseases can ease the deleterious effects of disease progression, be used to maintain functional capacity, and improve aspects of quality of life.
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OBJECTIVE: Evaluate the interaction between high-intensity inspiratory muscle training (IMT) and aerobic exercise on physical capacity, respiratory muscle strength, peripheral muscle strength, and quality of life of patients who underwent coronary artery bypass grafting (CABG). METHODS: Twenty-four patients underwent CABG were randomized into two groups. During 36 sessions, one group received IMT associated with aerobic exercise and the other group received only aerobic exercise. Primary outcome was the distance in the six-minute walk distance (6MWD) test. Secondary outcomes included respiratory muscle strength, peripheral muscle strength, and quality of life. Measures were taken at the baseline, at the 12th session, the 24th session, and 36th session. RESULTS: Baseline characteristics were similar between the groups. There was no statistically significant difference between the two groups in any outcome [6MWD - P=0.935; peak oxygen consumption (PeakVO2) - P=0.853; maximal inspiratory pressure (MIP) - P=0.243; maximal expiratory pressure (MEP) - P=0.268; sitting-rising test (SRT) - P=0.212], but there was interaction in MIP (P=0.000) and all outcomes improved in the two groups (6MWD - P=0.000; PeakVO2 - P=0.000; MIP - P=0.000; MEP - P=0.000; SRT - P=0.000). CONCLUSION: There was an improvement of all outcomes in both groups, but IMT was not able to provide additional benefits. The use of this combination should be used with caution to not generate higher costs in the rehabilitation process of these patients.
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Ejercicios Respiratorios/métodos , Puente de Arteria Coronaria/rehabilitación , Terapia por Ejercicio/métodos , Ejercicio Físico/fisiología , Ejercicios de Estiramiento Muscular/métodos , Calidad de Vida , Anciano , Análisis de Varianza , Tolerancia al Ejercicio , Femenino , Humanos , Masculino , Presiones Respiratorias Máximas , Persona de Mediana Edad , Fuerza Muscular/fisiología , Consumo de Oxígeno/fisiología , Reproducibilidad de los Resultados , Músculos Respiratorios/fisiología , Estadísticas no Paramétricas , Encuestas y Cuestionarios , Factores de Tiempo , Resultado del TratamientoRESUMEN
Abstract Objective: Evaluate the interaction between high-intensity inspiratory muscle training (IMT) and aerobic exercise on physical capacity, respiratory muscle strength, peripheral muscle strength, and quality of life of patients who underwent coronary artery bypass grafting (CABG). Methods: Twenty-four patients underwent CABG were randomized into two groups. During 36 sessions, one group received IMT associated with aerobic exercise and the other group received only aerobic exercise. Primary outcome was the distance in the six-minute walk distance (6MWD) test. Secondary outcomes included respiratory muscle strength, peripheral muscle strength, and quality of life. Measures were taken at the baseline, at the 12th session, the 24th session, and 36th session. Results: Baseline characteristics were similar between the groups. There was no statistically significant difference between the two groups in any outcome [6MWD - P=0.935; peak oxygen consumption (PeakVO2) - P=0.853; maximal inspiratory pressure (MIP) - P=0.243; maximal expiratory pressure (MEP) - P=0.268; sitting-rising test (SRT) - P=0.212], but there was interaction in MIP (P=0.000) and all outcomes improved in the two groups (6MWD - P=0.000; PeakVO2 - P=0.000; MIP - P=0.000; MEP - P=0.000; SRT - P=0.000). Conclusion: There was an improvement of all outcomes in both groups, but IMT was not able to provide additional benefits. The use of this combination should be used with caution to not generate higher costs in the rehabilitation process of these patients.
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Humanos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Calidad de Vida , Ejercicios Respiratorios/métodos , Ejercicio Físico/fisiología , Puente de Arteria Coronaria/rehabilitación , Terapia por Ejercicio/métodos , Ejercicios de Estiramiento Muscular/métodos , Consumo de Oxígeno/fisiología , Factores de Tiempo , Músculos Respiratorios/fisiología , Encuestas y Cuestionarios , Reproducibilidad de los Resultados , Análisis de Varianza , Resultado del Tratamiento , Tolerancia al Ejercicio , Estadísticas no Paramétricas , Fuerza Muscular/fisiología , Presiones Respiratorias MáximasRESUMEN
OBJECTIVE: The aim of this study was to evaluate the acute effects of low-level laser therapy (LLLT) on the functional capacity to exercise tested by incremental shuttle walking test (ISWT) after coronary artery bypass graft (CABG) surgery. METHODS: Fifteen male patients (60 ± 9 years) were crossed over during the experiment, to compare the outcomes after active LLLT and placebo LLLT treatments. LLLT (850 nm, 200 mW, 30 J to each point, resulting in a total of 240 J per quadriceps muscle), using a multidiode cluster (five spots; 6 J/spot) in eight points per leg was performed 3 min before the ISWT. We analyzed distance walked, Borg scale of perceived exertion, heart rate, and brachial arterial blood pressure. Markers of tissue damage [lactate dehydrogenase (LDH)] and oxidative stress [lipid peroxidation, total thiol levels, and antioxidant enzyme activity of superoxide dismutase (SOD) and catalase (CAT)] were also measured in peripheral blood. RESULTS: Comparison of the distances walked revealed no significant differences between the LLLT and placebo LLLT groups (p = 0.779). Regarding the Borg scale (p = 0.567), heart rate (p = 0.506) as well as systolic and diastolic blood pressure (p = 0.164 and p = 0.140, respectively), no differences were observed between LLLT and placebo LLLT groups. Application of LLLT was not able to change levels of LDH (p = 0.214), oxidative lipid damage (p = 0.733), total thiol levels (p = 0.925), SOD (p = 0.202), and CAT (p = 0.825) enzyme activities. CONCLUSIONS: Acute LLLT improved neither functional capacity to exercise nor the markers of oxidation after CABG. TRIAL REGISTRATION: Registered as a clinical trial (NCT02688426).
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Puente de Arteria Coronaria , Enfermedad de la Arteria Coronaria/rehabilitación , Enfermedad de la Arteria Coronaria/cirugía , Tolerancia al Ejercicio/fisiología , Terapia por Luz de Baja Intensidad , Músculo Cuádriceps/fisiopatología , Anciano , Enfermedad de la Arteria Coronaria/fisiopatología , Estudios Cruzados , Prueba de Esfuerzo , Humanos , Masculino , Persona de Mediana Edad , Fuerza Muscular/fisiología , Recuperación de la Función/fisiologíaRESUMEN
Introdução: O tratamento através da eletroterapia está cada vezmais utilizado como um recurso terapêutico para redução de quadrosálgicos na Fisioterapia. No entanto, são escassos os estudos analisandoos efeitos da radiofrequência de modo contínuo não ablativo empacientes com fibromialgia. Objetivo: Este estudo objetivou avaliaros efeitos da terapia por radiofrequência monopolar (RFM) na dore no cotidiano de mulheres com fibromialgia. Método: Participaramdeste estudo mulheres com diagnóstico clínico de fibromialgia, queforam submetidas a 8 sessões de RFM. Os atendimentos ocorreram 2vezes por semana. Os resultados do tratamento foram avaliados pelaEscala Visual Analógica (EVA) e pelo Fibromyalgia Impact Questionary(FIQ). Para comparar os resultados pré e pós tratamentoutilizou-se o teste T Pareado do software Statistica 7.1. Resultados:Participaram deste estudo 9 mulheres com idade média de 53,25 (±8,48) anos. Verificou-se alívio da dor imediatamente após as sessõesde RFM (p < 0,01). Houve repercussão positiva do tratamento nocotidiano dessas pacientes, visto que ocorreu significativa reduçãodo escore do FIQ após as 8 sessões (p = 0,03). Conclusão: A partirdos resultados deste estudo, sugere-se que a terapia por RFM podeser mais um aliado do fisioterapeuta para o tratamento de pacientescom fibromialgia. Contudo, os resultados desta pesquisa devem seranalisados com cautela, pois não houve um grupo controle paragarantir que os resultados positivos deveram-se unicamente ao tratamentoe não a outros fatores desconsiderados pelos pesquisadores.
Introduction: The treatment by electrotherapy is increasinglyused as a therapeutic resource for reducing painful picture in PhysicalTherapy. However, there are few studies analyzing the effectsof continuous and non-ablative radiofrequency in patients with fibromyalgia.Objective: This study evaluated the effects of monopolarradiofrequency on pain and daily life of women with fibromyalgia.Methods: The study included women diagnosed with fibromyalgia,who underwent eight sessions of RFM monopolar radiofrequency.The sessions occurred twice a week. The treatment results wereevaluated by Visual Analogue Scale (VAS) and the FibromyalgiaImpact Questionnaire (FIQ). To compare the results before and aftertreatment, we used paired t-test from software Statistica 7.1. Results:The study included 9 women with mean age of 53.25 ± 8.48 years.Pain decreased immediately after the sessions of RFM (p < 0.01).There was positive impact in the daily treatment of these patients,with a significant reduction in the FIQ score after 8 sessions (p =0.03). Conclusion: The results suggest that RFM therapy can be aphysiotherapist help for the treatment of patients with fibromyalgia.However, this study should be analyzed with caution, becausethere was no control group to ensure that positive results were duesolely to the treatment and not to other factors not considered bythe researchers.
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Humanos , Fibromialgia , Dolor , Ondas de RadioRESUMEN
Introdução: O tratamento através de eletroterapia é um recurso fisioterapêutico cada vez mais utilizado para a redução de quadros álgicos. No entanto, são escassos os estudos analisando os efeito da radiofrequência de modo contínuo não ablativo em pacientes com fibromialgia. Objetivo: Este estudo objetivou avaliar os efeitosda terapia por radiofrequência monopolar (RFM) na dor e no cotidiano de mulheres com fibromialgia. Método: Participaram deste estudo mulheres com diagnóstico clínico de fibromialgia, que foram submetidas a 8 sessões de RFM. Os atendimentos ocorreram 2 vezes por semana. Os resultados do tratamento foram avaliados pela Escala Visual Analógica (EVA) e pelo Fibromyalgia Impact Questionary (FIQ). Para comparar os resultados pré e pós tratamento utilizou-se o teste T Pareado do software Statistica 7.1. Resultados: Participaram deste estudo 9 mulheres com idade média de 53,25 (± 8,48) anos.Verificou-se alívio da dor imediatamente após as sessões de RFM (p <0,01). Houve repercussão positiva do tratamento no cotidiano dessas pacientes, visto que ocorreu significativa redução do escore do FIQ após as 8 sessões (p = 0,03). Conclusão: A partir dos resultados deste estudo, sugere-se que a terapia por RFM pode ser mais um aliado do fisioterapeuta para o tratamento de pacientes com fibromialgia. Contudo, os resultados desta pesquisa devem ser analisados com cautela, pois não houve um grupo controle para garantir que os resultados positivos deveram-se unicamente ao tratamento e não a outros fatores desconsiderados pelos pesquisadores.
Introduction: The treatment by electrotherapy is increasingly used as a therapeutic resource for reducing painful picture in Physical Therapy. However, there are few studies analyzing the effects of continuous and non-ablative radiofrequency in patients with fibromyalgia. Objective: This study evaluated the effects of monopolar radiofrequency on pain and daily life of women with fibromyalgia. Methods: The study included women diagnosed with fibromyalgia, who underwent eight sessions of RFM monopolar radiofrequency. The sessions occurred twice a week. The treatment results were evaluated by Visual Analogue Scale (VAS) and the Fibromyalgia Impact Questionnaire (FIQ). To compare the results before and after treatment, we used paired t-test from software Statistica 7.1. Results: The study included 9 women with mean age of 53.25 ± 8.48 years. Pain decreased immediately after the sessions of RFM (p < 0.01).There was positive impact in the daily treatment of these patients, with a significant reduction in the FIQ score after 8 sessions (p =0.03). Conclusion: The results suggest that RFM therapy can be an physiotherapists help for the treatment of patients with fibromyalgia. However, this study should be analyzed with caution, because there was no control group to ensure that positive results were due solely to the treatment and not to other factors not considered by the researchers.