A time-series COVID-19 policy outcome analysis tool to measure human behavior from a herd instinct perspective.

Purpose: There are 47 municipalities and prefectures in Japan that operate similar COVID-19 policies in a unified manner. There are significant differences regarding their policy outcomes. In order to investigate when the outcomes are different, we made a COVID-19 policy outcome analysis tool, jpcovid for evaluating time-series scores of individual prefectures, not a policy analysis tool. Methods: Scoring policies is based on a single population mortality metric: the number of COVID-19 deaths divided by the population in millions from a demographic perspective. Results: Although uniformed policies have been adopted by the 47 prefectures in Japan, there are significant differences in the calculated scores among the 47 prefectures. This difference can be caused by differences in the herding instincts of the community with COVID-19 variants. The herd instinct is an inherent tendency to associate with others and follow the group's behavior or a behavior wherein people tend to react to the actions of others without considering the reason. The snapshot scoring tool, jpscore showed that Niigata has the best score of 67.9 while Osaka has the worst score of 727.9. jpcovid allows users to identify when herd instincts made changes in time-series scores. Conclusions: This is the world's first large-scale measurement on the herd instinct of prefectures in Japan. The proposed method can be applied to other countries in general. Supplementary Information: The online version contains supplementary material available at 10.1007/s12553-023-00759-x.

A helical amplification system composed of artificial nucleic acids.

Herein we report an amplification system of helical excess triggered by nucleic acid hybridization for the first time. It is usually impossible to prepare achiral nanostructures composed of nucleic acids because of their intrinsic chirality. We used serinol nucleic acid (SNA) oligomers for the preparation of achiral nanowires because SNA oligomers with symmetrical sequences are achiral. Nanowire formation was confirmed by atomic force microscopy and size exclusion chromatography. When a chiral nucleic acid with a sequence complementary to SNA was added to the nanostructure, helicity was induced and a strong circular dichroism signal was observed. The SNA nanowire could amplify the helicity of chiral nucleic acids through nucleobase stacks. The SNA nanostructures have potential for use as platforms to detect chiral biomolecules under aqueous conditions because SNA can be readily functionalized and is water-soluble.