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J Pediatr Endocrinol Metab ; 19 Suppl 1: 371-80, 2006 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-16700313

RESUMEN

BACKGROUND: Situated in a suprasellar location, craniopharyngiomas produce devastating endocrinological manifestations, visual impairment, and raised intracranial pressure, presenting a formidable disease entity for the neurosurgeon as well as the 'craniopharyngioma team'. OBJECTIVE: To evaluate direct postoperative and long-term results based on the extent of surgical removal and administration of radiotherapy. PATIENTS AND METHODS: Sixty-two new cases of pediatric craniopharyngioma were divided into three groups according to extent of removal: A (complete), B (subtotal), and C (partial). Groups A and B receiving primary postoperative radiotherapy were tagged groups Ar and Br. RESULTS: Group A had significantly less recurrence rate than group B (p < 0.005); however, direct postoperative morbidity and mortality were worse (p < 0.05). Group C fared worse than the other two groups. In groups A and B with recurrence and in groups Ar and Br, radiotherapy provided long-term control. CONCLUSION: The aim at first surgery should be total removal. Subtotal removal is warranted for more resilient tumors, while partial removal should be avoided as it provides poor results. Adjuvant radiotherapy is a useful tool in providing long-term tumor control.


Asunto(s)
Craneofaringioma/terapia , Neoplasias Hipofisarias/terapia , Adolescente , Niño , Preescolar , Terapia Combinada , Craneofaringioma/radioterapia , Craneofaringioma/cirugía , Egipto , Femenino , Estudios de Seguimiento , Humanos , Lactante , Imagen por Resonancia Magnética , Masculino , Recurrencia Local de Neoplasia , Procedimientos Neuroquirúrgicos , Neoplasias Hipofisarias/radioterapia , Neoplasias Hipofisarias/cirugía , Calidad de Vida , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
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