Growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow's milk protein allergy.

Objective: To evaluate growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula (eHCF) in infants with cow's milk protein allergy (CMPA). Methods: A total of 226 infants (mean ± SD age: 106.5 ± 39.5 days, 52.7% were girls) with CMPA who received eHCF comprising at least half of the daily dietary intake were included. Data on anthropometrics [weight for age (WFA), length for age (LFA) and weight for length (WFL) z-scores] were recorded at baseline (visit 1), while data on infant feeding and stool records, anthropometrics and Infant Feeding and Stool Patterns and Formula Satisfaction Questionnaires were recorded at visit 2 (on Days 15 ± 5) and visit 3 (on Days 30 ± 5). Results: From baseline to visit 2 and visit 3, WFA z-scores (from -0.60 ± 1.13 to -0.54 ± 1.09 at visit 2, and to -0.44 ± 1.05 at visit 3, p < 0.001) and WFL z-scores (from -0.80 ± 1.30 to -0.71 ± 1.22 at visit 2, and to -0.64 ± 1.13 at visit 3, p = 0.002) were significantly increased. At least half of infants never experienced irritability or feeding refusal (55.7%) and spit-up after feeding (50.2%). The majority of mothers were satisfied with the study formula (93.2%), and wished to continue using it (92.2%). Conclusions: In conclusion, eHCF was well-accepted and tolerated by an intended use population of infants ≤ 6 months of age with CMPA and enabled adequate volume consumption and improved growth indices within 30 days of utilization alongside a favorable gastrointestinal tolerance and a high level of parental satisfaction.

Evaluation of Mediterranean diet adherence in children diagnosed with pancreatitis: a case-control study / Evaluación de la adhesión a la dieta mediterránea en niños diagnosticados de pancreatitis: estudio de casos y controles

BACKGROUND: the incidence of childhood acute pancreatitis has been increasing in the last two decades. The number of studies on the effects of diet on the pathogenesis of pancreatitis is very small. The aim of this study was to evaluate adherence to the Mediterranean diet among children with acute pancreatitis. MATERIAL AND METHOD: this study was conducted by administering the Mediterranean Diet Quality Index (KIDMED) to 100 children -children diagnosed with acute pancreatitis (n = 50) and a control group (n = 50). RESULTS: there was a statistically significant difference between groups in terms of body mass index Z-score (p = 0.017). When the KIDMED scores of the children diagnosed with pancreatitis (4.48 ± 2.45) and the control group (6.62 ± 2.18) were compared, the KIDMED scores of the children diagnosed with pancreatitis group were significantly lower (u = 638.5; p < 0.001). Those with a moderate KIDMED index (score: 4-7) (OR: 3.734, 95 % CI, 1.068-13.058, p = 0.039) and those with a poor KIDMED index (score ≤ 3) (OR: 6.444, 95 % CI, 1.595 -26.075, p = 0.009) were found to have an increased risk of developing pancreatitis. It was found that the risk of pancreatitis increased with age (OR: 1.136, 95 % CI, 1.020-1.266, p = 0.021). CONCLUSION: according to the data obtained from our study, it was found that the pancreatitis group had poorer dietary habits than the control group. Larger and multicenter studies are needed to evaluate the role of diet in pancreatitis development

INTRODUCCIÓN: la incidencia de la pancreatitis aguda infantil ha aumentado en las últimas dos décadas. La pancreatitis aguda es una inflamación reversible del páncreas que comienza con una lesión de las células acinares. El diagnostico de pancreatitis aguda se realiza según los criterios INSPPIRE. El número de estudios sobre los efectos de la dieta en la patogenia de la pancreatitis es muy pequeño. El objetivo de este estudio fue evaluar la adherencia a la dieta mediterránea de los niños con pancreatitis aguda. MATERIAL Y MÉTODOS: este estudio se realizó administrando el Índice de Calidad de la Dieta Mediterránea (KIDMED) a 100 niños: niños diagnosticados de pancreatitis aguda (n = 50) y un grupo de control (n = 50). RESULTADOS: hubo una diferencia estadísticamente significativa entre los grupos en términos del puntaje Z del índice de masa corporal (p = 0,017). Cuando se compararon las puntuaciones KIDMED de los niños diagnosticados de pancreatitis (4,48 ± 2,45) y del grupo de control (6,62 ± 2,18), las puntuaciones KIDMED del grupo diagnosticado de pancreatitis fueron significativamente más bajas (u = 638,5; p < 0,001). Aquellos con un índice KIDMED moderado (puntaje: 4-7) (OR: 3,734; IC 95 %: 1,068-13,058, p = 0,039) y aquellos con un índice KIDMED pobre (puntaje ≤ 3) (OR: 6,444; IC 95%: 1,595-26,075, p = 0,009) presentaban mayor riesgo de desarrollar pancreatitis. Se encontró que el riesgo de pancreatitis aumentaba a medida que aumentaba la edad (OR: 1,136; IC 95%: 1,020-1,266, p = 0,021). CONCLUSIÓN: según los datos obtenidos de nuestro estudio, se encontró que el grupo con pancreatitis presentaba peores hábitos alimentarios que el grupo de control. Se necesitan estudios más grandes y multicéntricos para evaluar el papel de la dieta en el desarrollo de la pancreatitis

Evaluation of Mediterranean diet adherence in children diagnosed with pancreatitis: a case-control study.

INTRODUCTION: Background: the incidence of childhood acute pancreatitis has been increasing in the last two decades. The number of studies on the effects of diet on the pathogenesis of pancreatitis is very small. The aim of this study was to evaluate adherence to the Mediterranean diet among children with acute pancreatitis. Material and method: this study was conducted by administering the Mediterranean Diet Quality Index (KIDMED) to 100 children -children diagnosed with acute pancreatitis (n = 50) and a control group (n = 50). Results: there was a statistically significant difference between groups in terms of body mass index Z-score (p = 0.017). When the KIDMED scores of the children diagnosed with pancreatitis (4.48 ± 2.45) and the control group (6.62 ± 2.18) were compared, the KIDMED scores of the children diagnosed with pancreatitis group were significantly lower (u = 638.5; p < 0.001). Those with a moderate KIDMED index (score: 4-7) (OR: 3.734, 95 % CI, 1.068-13.058, p = 0.039) and those with a poor KIDMED index (score ≤ 3) (OR: 6.444, 95 % CI, 1.595 -26.075, p = 0.009) were found to have an increased risk of developing pancreatitis. It was found that the risk of pancreatitis increased with age (OR: 1.136, 95 % CI, 1.020-1.266, p = 0.021). Conclusion: according to the data obtained from our study, it was found that the pancreatitis group had poorer dietary habits than the control group. Larger and multicenter studies are needed to evaluate the role of diet in pancreatitis development.

INTRODUCCIÓN: Introducción: la incidencia de la pancreatitis aguda infantil ha aumentado en las últimas dos décadas. La pancreatitis aguda es una inflamación reversible del páncreas que comienza con una lesión de las células acinares. El diagnostico de pancreatitis aguda se realiza según los criterios INSPPIRE. El número de estudios sobre los efectos de la dieta en la patogenia de la pancreatitis es muy pequeño. El objetivo de este estudio fue evaluar la adherencia a la dieta mediterránea de los niños con pancreatitis aguda. Material y métodos: este estudio se realizó administrando el Índice de Calidad de la Dieta Mediterránea (KIDMED) a 100 niños: niños diagnosticados de pancreatitis aguda (n = 50) y un grupo de control (n = 50). Resultados: hubo una diferencia estadísticamente significativa entre los grupos en términos del puntaje Z del índice de masa corporal (p = 0,017). Cuando se compararon las puntuaciones KIDMED de los niños diagnosticados de pancreatitis (4,48 ± 2,45) y del grupo de control (6,62 ± 2,18), las puntuaciones KIDMED del grupo diagnosticado de pancreatitis fueron significativamente más bajas (u = 638,5; p < 0,001). Aquellos con un índice KIDMED moderado (puntaje: 4-7) (OR: 3,734; IC 95 %: 1,068-13,058, p = 0,039) y aquellos con un índice KIDMED pobre (puntaje ≤ 3) (OR: 6,444; IC 95%: 1,595-26,075, p = 0,009) presentaban mayor riesgo de desarrollar pancreatitis. Se encontró que el riesgo de pancreatitis aumentaba a medida que aumentaba la edad (OR: 1,136; IC 95%: 1,020-1,266, p = 0,021). Conclusión: según los datos obtenidos de nuestro estudio, se encontró que el grupo con pancreatitis presentaba peores hábitos alimentarios que el grupo de control. Se necesitan estudios más grandes y multicéntricos para evaluar el papel de la dieta en el desarrollo de la pancreatitis.

Life quality and empathy in children with celiac disease.

OBJECTIVE: This study aims to investigate the associations between celiac disease (CD) and children's life quality and empathy level. METHODS: In this study, all participants aged 8-14 years completed the Turkish version of the Pediatric Quality of Life Inventory and Index of Empathy for Children and Adolescents. Parents were also applied to the structured survey. RESULTS: This study included a study group consisting of 45 children with celiac disease and a control group with 48 healthy children. The total scores of PedsQL were significantly lower for children with celiac disease when compared to the control group (p<0.05). When the sub-scores of PedsQL were evaluated, scores except the school functioning score (ScFS) were significantly lower in the study group (p<0.05). When IECA was analyzed, total empathy scale scores (TESS) were measured significantly higher in the study group (p<0.05). CONCLUSION: This study supports the argument that the quality of life decreases in children with CD. Future studies should aim to develop support models to improve the life quality of celiac patients. To our knowledge, this is the first study proving the increased empathy levels of children with CD. The determinants of the increased empathy levels should be focussed on future studies.