RESUMEN
Oropouche fever is a zoonotic dengue-like syndrome caused by Oropouche virus. In August-September 2020, dengue-like syndrome developed in 41 patients in a remote rainforest village in French Guiana. By PCR or microneutralization, 23 (82.1%) of 28 tested patients were positive for Oropouche virus, documenting its emergence in French Guiana.
Asunto(s)
Infecciones por Bunyaviridae , Orthobunyavirus , Infecciones por Bunyaviridae/epidemiología , Brotes de Enfermedades , Guyana Francesa/epidemiología , Humanos , Orthobunyavirus/genéticaRESUMEN
Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).
Asunto(s)
Mycobacterium leprae/efectos de los fármacos , Adolescente , Adulto , Anciano , Farmacorresistencia Bacteriana , Femenino , Genotipo , Humanos , Lepra/tratamiento farmacológico , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Mycobacterium leprae/clasificación , Mycobacterium leprae/genética , Polimorfismo de Nucleótido Simple , América del SurRESUMEN
Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).
Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Anciano , América del Sur , Pruebas de Sensibilidad Microbiana , Polimorfismo de Nucleótido Simple , Farmacorresistencia Bacteriana , Genotipo , Lepra/tratamiento farmacológico , Mycobacterium leprae/clasificación , Mycobacterium leprae/efectos de los fármacos , Mycobacterium leprae/genéticaRESUMEN
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.