Effectiveness and safety of once-weekly semaglutide: findings from the SEMACOL-REAL retrospective multicentric observational study in Colombia.

Introduction: Diabetes stands as one of the leading causes of death worldwide. Glucagon-like peptide-1 receptor agonists rank among the most effective medications for lowering blood glucose and body weight, as well as reducing cardiovascular risk in individuals with diabetes. Observational studies complement experimental evidence in new settings, different populations, and real-world healthcare practices. Methods: A multicentric observational study of adults with type 2 diabetes treated with once-weekly subcutaneous semaglutide in four health centers in Colombia was conducted. The protocol for the present study was not pre-registered. Results: Data from 186 patients were included. Most patients were women (57%) with a mean age of 62.8 ± 12.1 years. One year of once-weekly semaglutide usage was associated with a mean reduction in HbA1C of -1.47% (95% CI -1.76, -1.17), weight loss of -4.23 kg (95% CI -5.34, -3.12), and albumin/creatinine ratio of -18.6 mg/g (95% CI -60.2, -5.9). Approximately half the treated patients achieved a level of HbA1c ≤7% by the end of follow-up. Adverse events were rare and consistent with clinical trial safety profiles. Conclusion: In Colombia, administering semaglutide subcutaneously once a week over a 1-year period led to an average weight loss of 4.2 kg and a decrease of 1.4% in HbA1c.

Maternal and perinatal outcomes in pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion and real time continuous glucose monitoring in two specialized centers in Medellin, Colombia.

OBJECTIVE: We assessed maternal and perinatal outcomes in pregnant women with type 1 diabetes, treated with continuous subcutaneous insulin infusion and real time continuous glucose monitoring. METHODS: This is a retrospective study, analyzing the basal characteristics, glycemic control, maternal and perinatal outcomes of pregnant women with type 1 diabetes, who were on an insulin pump with continuous glucose monitoring between 2011 and 2015. RESULTS: Fourteen patients were included. The median age was 33 and disease duration 12 years. Indications for therapy were mainly poor glycemic control and severe hypoglycemia. The median A1c decrease was 1.02% between the first and third trimester. Pregnancies were associated with complications: 7.1% of the patients had diabetic ketoacidosis, 7.1% had an abortion, 28.5% gestational hypertension and 12.2% preeclampsia. The median gestational age at birth was 37 weeks and four days; the frequency of preterm birth was 7.1% and macrosomia 21.4%. There were no congenital malformations or perinatal death. CONCLUSIONS: Baseline characteristics and results of patients in this study were similar to those reported in the previous literature. Continuous subcutaneous insulin infusion with continuous glucose monitoring is an alternative treatment option for pregnant women with type 1 diabetes before or during pregnancy.

Fenotipo e historia natural de la enfermedad inflamatoria intestinal en un centro de referencia en Medellín-Colombia / Phenotypes and natural history of inflammatory bowel disease (IBD) in a referral population in Medellín, Colombia

La frecuencia de enfermedad infl amatoria intestinal, tanto de colitis ulcerativa como enfermedad de Crohn seha incrementado a nivel mundial y es necesario establecer la epidemiología y determinar el comportamientoclínico y endoscópico de estas entidades en nuestro medio. Metodología: Este es un estudio observacional descriptivo, en el que se evaluaron sistemáticamentepacientes con diagnóstico de enfermedad infl amatoria intestinal que consultaron al Hospital Pablo TobónUribe, entre agosto de 2001 y julio de 2009. Resultados: Un total de 202 pacientes presentaba diagnóstico de enfermedad infl amatoria intestinal, conuna relación de colitis ulcerativa (80,7%) y enfermedad de Crohn (15,8%) de 4.9:1, con una distribuciónsimilar por géneros. En cuanto a las manifestaciones clínicas, la colitis ulcerativa presenta más diarrea ysangrado, pero menos dolor abdominal y pérdida de peso, comparados con sujetos con enfermedad deCrohn; esta diferencia fue signifi cativa (p < 0,001). El porcentaje de nuestros pacientes con manifestacionesextraintestinales (27,7%) fue similar al de otras poblaciones, con predominio del compromiso articular. Seencontró asociación signifi cativa entre tabaquismo y enfermedad de Crohn. La distribución de la extensión de colitis ulcerativa en nuestros pacientes es 19,5% proctitis, 45% colitis izquierda y 35,5% colitis extensa. En enfermedad de Crohn, la localización más frecuente fue ileocolónica 50%, íleon terminal 18,8%, colónica 28,1% y solo 3,1% tenía compromiso del tracto digestivo superior. En cuanto a severidad, 17,2% de individuos con colitis ulcerativa son asintomáticos (S0) al ingreso al estudio, 27,8% presentan actividad leve (S1), 32,0% moderada (S2) y 23,1% severa (S4). En enfermedad de Crohn, 34,4% de los pacientes presentan comportamiento infl amatorio, 31,3% estenótico, 21,9% perianal, 6,3% penetrante, y 6,3% tienen comportamiento estenótico y perianal...

Worldwide the frequencies of infl ammatory bowel disease, ulcerative colitis and Crohn’s disease have allincreased. In our own environment it has become necessary to establish the epidemiology of these entitiesand to determine their clinical and endoscopic behavior. Methodology: This is a descriptive observational study which systematically evaluated patients with infl ammatory bowel disease at the Pablo Tobon Uribe Hospital between August 2001 and July 2009. Results: Of 202 patients with diagnoses of infl ammatory bowel disease 80.7% had ulcerative colitis and 15.8% had Crohn’s disease. The ratio was 4.9 to 1 with similar distributions among male and female patients.Patients with ulcerative colitis presented more diarrhea and bleeding, but less abdominal pain and weightloss, than those with Crohn’s disease. This difference was signifi cant (p <0.001). The percentage of ourpatients with extraintestinal manifestations (27.7%) was similar to other populations in which compromisedarticulation predominates. A signifi cant association between smoking and Crohn’s disease was found. 19.5%of our patients had proctitis, 45% had left sided colitis, and 35.5% had extensive colitis. The most commonlocation of Crohn’s disease was in the ileocolonic region (50%), while 18.8% were located in the terminal ileum, and 28.1% were in the colonic region. Only 3.1% had upper gastrointestinal tract involvement...