Limitation of life support treatments in Spanish Intensive Care Units: Analysis of the ETHICUS II study.

OBJECTIVE: The aim of this study is to describe the results of Spanish ICUs in ETHICUS II study. DESIGN: Planned substudy of patients from ETHICUS II study. SETTING: 12 Spanish ICU. PATIENTS OR PARTICIPANTS: Patients admitted to Spanish ICU who died or in whom a limitation of life-sustaining treatment (LLST) was decided during a recruitment period of 6 months. INTERVENTIONS: Follow-up of patients was performed until discharge from the ICU and 2 months after the decision of LLST or death. MAIN VARIABLES OF INTEREST: Demographic characteristics, clinical profile, type of decision of LLST, time and form in which it was adopted. Patients were classified into 4 categories according to the ETHICUS II study protocol: withholding or withdrawing life-sustaining therapy, active shortening of the dying process, failed cardiopulmonary resuscitation and patients with brain death. RESULTS: A total of 795 patients were analyzed; 129 patients died after CPR, 129 developed brain death. LLST was decided in 537 patients, 485 died in the ICU, 90.3%. The mean age was 66.19 years ± 14.36, 63.8% of male patients. In 221 (41%) it was decided to withdraw life-sustaining treatments and in 316 (59%) withholding life-sustaining treatments. Nineteen patients (2.38%) had advance living directives. CONCLUSIONS: The predominant clinical profile when LTSV was established was male patients over 65 years with mostly cardiovascular comorbidity. We observed that survival was higher in LLST decisions involving withholding of treatments compared to those in which withdrawal was decided. Spain has played a leading role in both patient and ICU recruitment participating in this worldwide multicenter study.

Early Tracheostomy for Managing ICU Capacity During the COVID-19 Outbreak: A Propensity-Matched Cohort Study.

BACKGROUND: During the first wave of the COVID-19 pandemic, shortages of ventilators and ICU beds overwhelmed health care systems. Whether early tracheostomy reduces the duration of mechanical ventilation and ICU stay is controversial. RESEARCH QUESTION: Can failure-free day outcomes focused on ICU resources help to decide the optimal timing of tracheostomy in overburdened health care systems during viral epidemics? STUDY DESIGN AND METHODS: This retrospective cohort study included consecutive patients with COVID-19 pneumonia who had undergone tracheostomy in 15 Spanish ICUs during the surge, when ICU occupancy modified clinician criteria to perform tracheostomy in Patients with COVID-19. We compared ventilator-free days at 28 and 60 days and ICU- and hospital bed-free days at 28 and 60 days in propensity score-matched cohorts who underwent tracheostomy at different timings (≤ 7 days, 8-10 days, and 11-14 days after intubation). RESULTS: Of 1,939 patients admitted with COVID-19 pneumonia, 682 (35.2%) underwent tracheostomy, 382 (56%) within 14 days. Earlier tracheostomy was associated with more ventilator-free days at 28 days (≤ 7 days vs > 7 days [116 patients included in the analysis]: median, 9 days [interquartile range (IQR), 0-15 days] vs 3 days [IQR, 0-7 days]; difference between groups, 4.5 days; 95% CI, 2.3-6.7 days; 8-10 days vs > 10 days [222 patients analyzed]: 6 days [IQR, 0-10 days] vs 0 days [IQR, 0-6 days]; difference, 3.1 days; 95% CI, 1.7-4.5 days; 11-14 days vs > 14 days [318 patients analyzed]: 4 days [IQR, 0-9 days] vs 0 days [IQR, 0-2 days]; difference, 3 days; 95% CI, 2.1-3.9 days). Except hospital bed-free days at 28 days, all other end points were better with early tracheostomy. INTERPRETATION: Optimal timing of tracheostomy may improve patient outcomes and may alleviate ICU capacity strain during the COVID-19 pandemic without increasing mortality. Tracheostomy within the first work on a ventilator in particular may improve ICU availability.

The Moderator Role of Passion for Work in the Association between Work Stressors and Secondary Traumatic Stress: A Cross-Level Diary Study among Health Professionals of Intensive Care Units.

BACKGROUND: Secondary traumatic stress (STS), a construct formed by compassion fatigue, shattered assumptions, and symptomatology, has been scarcely studied in intensive care units (ICU). In these units, healthcare workers encounter daily work stressors which impact on their health and well-being. Also, previous literature revealed a passion for caring among these workers, finding two types: harmonious passion, which may protect them against negative outcomes, and obsessive passion, which may boost negative consequences. We aim to study whether both types of passion could moderate the relationships between daily work stressors and STS. METHODS: In all, 265 assessments were collected at ICUs from different hospitals in Spain through a diary approach (53 health workers × 5 days at two time points per day). RESULTS: First, daily work stressors were positive predictors of symptomatology; secondly, dispositional harmonious passion was a negative predictor of both compassion fatigue and shattered assumptions, also presenting a buffering effect between daily work stressors and daily shattered assumptions. Finally, dispositional obsessive passion showed positive relationships with both shattered assumptions and symptomatology, also presenting a boosting effect between daily work stressors and daily symptomatology. CONCLUSIONS: This study allows us to deepen our understanding of STS in ICUs and to boost preventive proposals. Practical implications are discussed.

Nutritrauma: A Key Concept for Minimising the Harmful Effects of the Administration of Medical Nutrition Therapy.

Critically ill patients often require life support measures such as mechanical ventilation or haemodialysis. Despite the essential role of nutrition in patients' recovery, the inappropriate use of medical nutrition therapy can have deleterious effects, as is the case with the use of respiratory, circulatory, or renal support. To increase awareness and to monitor the effects of inappropriate medical nutrition therapy, we propose to introduce the concept of nutritrauma in clinical practice, defined as metabolic adverse events related to the inappropriate administration of medical nutrition therapy or inadequate nutritional monitoring.

Monitoring nutrition in the ICU.

BACKGROUND & AIMS: This position paper summarizes theoretical and practical aspects of the monitoring of artificial nutrition and metabolism in critically ill patients, thereby completing ESPEN guidelines on intensive care unit (ICU) nutrition. METHODS: Available literature and personal clinical experience on monitoring of nutrition and metabolism was systematically reviewed by the ESPEN group for ICU nutrition guidelines. RESULTS: We did not identify any studies comparing outcomes with monitoring versus not monitoring nutrition therapy. The potential for abnormal values to be associated with harm was clearly recognized. The necessity to create locally adapted standard operating procedures (SOPs) for follow up of enteral and parenteral nutrition is emphasised. Clinical observations, laboratory parameters (including blood glucose, electrolytes, triglycerides, liver tests), and monitoring of energy expenditure and body composition are addressed, focusing on prevention, and early detection of nutrition-related complications. CONCLUSION: Understanding and defining risks and developing local SOPs are critical to reduce specific risks.

ESPEN guideline on clinical nutrition in the intensive care unit.

Following the new ESPEN Standard Operating Procedures, the previous guidelines to provide best medical nutritional therapy to critically ill patients have been updated. These guidelines define who are the patients at risk, how to assess nutritional status of an ICU patient, how to define the amount of energy to provide, the route to choose and how to adapt according to various clinical conditions. When to start and how to progress in the administration of adequate provision of nutrients is also described. The best determination of amount and nature of carbohydrates, fat and protein are suggested. Special attention is given to glutamine and omega-3 fatty acids. Particular conditions frequently observed in intensive care such as patients with dysphagia, frail patients, multiple trauma patients, abdominal surgery, sepsis, and obesity are discussed to guide the practitioner toward the best evidence based therapy. Monitoring of this nutritional therapy is discussed in a separate document.

Limitation of life support techniques at admission to the intensive care unit: a multicenter prospective cohort study.

PURPOSE: To determine the frequency of limitations on life support techniques (LLSTs) on admission to intensive care units (ICU), factors associated, and 30-day survival in patients with LLST on ICU admission. METHODS: This prospective observational study included all patients admitted to 39 ICUs in a 45-day period in 2011. We recorded hospitals' characteristics (availability of intermediate care units, usual availability of ICU beds, and financial model) and patients' characteristics (demographics, reason for admission, functional status, risk of death, and LLST on ICU admission (withholding/withdrawing; specific techniques affected)). The primary outcome was 30-day survival for patients with LLST on ICU admission. Statistical analysis included multilevel logistic regression models. RESULTS: We recruited 3042 patients (age 62.5 ± 16.1 years). Most ICUs (94.8%) admitted patients with LLST, but only 238 (7.8% [95% CI 7.0-8.8]) patients had LLST on ICU admission; this group had higher ICU mortality (44.5 vs. 9.4% in patients without LLST; p < 0.001). Multilevel logistic regression showed a contextual effect of the hospital in LLST on ICU admission (median OR = 2.30 [95% CI 1.59-2.96]) and identified the following patient-related variables as independent factors associated with LLST on ICU admission: age, reason for admission, risk of death, and functional status. In patients with LLST on ICU admission, 30-day survival was 38% (95% CI 31.7-44.5). Factors associated with survival were age, reason for admission, risk of death, and number of reasons for LLST on ICU admission. CONCLUSIONS: The frequency of ICU admission with LLST is low but probably increasing; nearly one third of these patients survive for ≥ 30 days.

Impact of obesity in patients infected with 2009 influenza A(H1N1).

OBJECTIVE: A large proportion of patients infected with 2009 influenza A(H1N1) (A[H1N1]) are obese. Obesity has been proposed as a risk factor influencing outcome in these patients. However, its role remains unclear. We evaluate the outcome of patients who are obese and infected with A(H1N1) in the ICU, determining whether obesity is a risk factor for mortality. METHODS: This was a prospective, observational, and multicenter study performed in 144 ICUs in Spain. Data were obtained from the Grupo de Trabajo en Enfermedades Infecciosas de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (GTEI/SEMICYUC) registry. Adult patients with A(H1N1) that was confirmed by real-time polymerase chain reaction were included in the analysis. Patients who were obese (BMI > 30) were compared with patients who were nonobese. Cox regression analysis was used to determine adjusted mortality. Differences of P < .05 were considered significant. RESULTS: In January 2010, the GTEI/SEMICYUC registry had complete records for 416 patients. One hundred and fifty patients (36.1%) were obese, of whom 67 (44.7%) were morbidly obese (BMI > 40). Mechanical ventilation (MV) was more frequently applied in patients who were obese (64% vs 52.4%, P < .01) Patients with obesity remained on MV longer than patients who were nonobese (6.5 ± 10.3 days vs 9.3 ± 9.7 days, P = .02), had longer ICU length of stay (10.8 ± 12.1 days vs 13.7 ± 11.7 days, P = .03), and had longer hospitalization (18.2 ± 14.6 days vs 22.2 ± 16.5 days, P = .02). Mortality adjusted by severity and potential confounders identified that obesity was not significantly associated with ICU mortality (hazard ratio, 1.1; 95% CI, 0.69-1.75; P = .68). CONCLUSIONS: In our cohort, patients who were obese and infected with A(H1N1) did not have increased mortality. However, there was an association between obesity and higher ICU resource consumption.

Isolation of Aspergillus lentulus in Spain from a critically ill patient with chronic obstructive pulmonary disease.

Aspergillus lentulus was first described in the year 2005, and since it cannot be phenotypically distinguished from Aspergillus fumigatus, it is conceivable that earlier descriptions (before 2005) could be attributed to this new species. Currently invasive infections caused by A. lentulus are rare and very few cases have been previously published in neutropenic patients, all of them with fatal outcome. Here we report a critically ill non neutropenic patient with chronic obstructive pulmonary disease (COPD) who was admitted to the medical intensive care unit with an exacerbation of COPD and who had been treated with long term corticosteroids. A. fumigatus was cultured from two bronchial aspirates and in a third bronchial aspirate both A. lentulus and A. fumigatus were isolated. On two consecutive days detection of galactomannan in serum was negative whilst detection of (1-3) beta-D glucan was positive (> 518 pg/ml). Minimal inhibitory concentrations (MIC) for itraconazole, voriconazole, caspofungin and amphotericin B were high for this strain of A. lentulus. Given the high MIC values of A. lentulus to available antifungals, the accurate identification of this new species is warranted. To our knowledge, this is the first report of the isolation of A. lentulus in a non-neutropenic critically ill patient, although we note that since it was isolated only once from respiratory specimens, its implication as an etiologic agent of infection for this patient remains to be established.

Isolation of Aspergillus lentulus in Spain from a critically ill patient with chronic obstructive pulmonary disease

Aspergillus lentulus es un hongo de reciente descripción (año 2005) ypracticamente idéntico a Aspergillus fumigatus; posibles aislamientos deA. lentulus anteriores a 2005 eran identificados como A. fumigatus.Actualmente se han publicado muy pocos casos de infecciones invasorascausadas por A. lentulus, todos ellos con evolución fatal, en pacientesneutropénicos. Comunicamos el caso de un paciente crítico no neutropénicocon enfermedad pulmonar obstructiva crónica (EPOC) admitido en la unidadde cuidados intensivos médicos con una exacerbación de EPOC y quehabía sido sometido a un tratamiento prolongado con corticosteroides. Se aisló A. fumigatus en dos aspirados bronquiales, y A. lentulus y A. fumigatusde un tercero. En dos días consecutivos la detección de galactomanano ensuero fue negativa, mientras que la detección de (1-3) beta-D glucano fuepositiva (>518 pg/ml). Los valores de concentración mínima inhibitoria (CMI)obtenidos con el itraconazol, el voriconazol, la caspofungina y la anfotericinaB fueron altos para A. lentulus. Dado lo elevado de estos valores enA. lentulus, es necesaria la identificación precisa de esta nueva especie enaislamientos clínicos. A nuestro entender, este es el primer aislamiento de A.lentulus en un paciente crítico no-neutropénico, aunque como su aislamientose realizó una sola vez de secreciones respiratorias (dada la dificultad de laobtención de biopsias en este enfermo por su situación comprometida), suimplicación como agente etiológico de infección es dudosa en este enfermo(AU)

Aspergillus lentulus was first described in the year 2005, and since it cannotbe phenotypically distinguished from Aspergillus fumigatus, it is conceivablethat earlier descriptions (before 2005) could be attributed to this new species.Currently invasive infections caused by A. lentulus are rare and very few caseshave been previously published in neutropenic patients, all of them with fataloutcome. Here we report a critically ill non neutropenic patient with chronicobstructive pulmonary disease (COPD) who was admitted to the medicalintensive care unit with an exacerbation of COPD and who had been treatedwith long term corticosteroids. A. fumigatus was cultured from two bronchialaspirates and in a third bronchial aspirate both A. lentulus and A. fumigatuswere isolated. On two consecutive days detection of galactomannan in serumwas negative whilst detection of (1-3) beta-D glucan was positive(> 518 pg/ml). Minimal inhibitory concentrations (MIC) for itraconazole,voriconazole, caspofungin and amphotericin B were high for this strain ofA. lentulus. Given the high MIC values of A. lentulus to available antifungals,the accurate identification of this new species is warranted. To our knowledge,this is the first report of the isolation of A. lentulus in a non-neutropeniccritically ill patient, although we note that since it was isolated only once fromrespiratory specimens, its implication as an etiologic agent of infection for thispatient remains to be established(AU)

The early phase of the minute ventilation recovery curve predicts extubation failure better than the minute ventilation recovery time.

STUDY OBJECTIVES: To determine, in patients who had successful outcomes in spontaneous breathing trials (SBTs), whether the analysis of the minute ventilation (Ve) recovery time obtained by minute-by-minute sequential monitoring after placing the patient back on mechanical ventilation (MV) may be useful in predicting extubation outcome. DESIGN: Twelve-month prospective observational study. SETTING: Medical-surgical ICU of a university hospital. PATIENTS: Ninety-three patients receiving > 48 h of MV. INTERVENTIONS: Baseline respiratory parameters (ie, respiratory rate, tidal volume, and Ve) were measured under pressure support ventilation prior to the SBT. After tolerating the SBT, patients again received MV with their pre-SBT ventilator settings, and respiratory parameters were recorded minute by minute. MEASUREMENTS AND RESULTS: Seventy-four patients (80%) were successfully extubated, and 19 patients (20%) were reintubated. Reintubated patients were similar to non-reintubated patients in baseline respiratory parameters and baseline variables, except for age and COPD diagnosis. The recovery time needed to reduce Ve to half the difference between the Ve measured at the end of a successful SBT and basal Ve (RT50%DeltaVe) was lower in patients who had undergone successful extubation than in those who had failed extubation (mean [+/- SD] time, 2.7 +/- 1.2 vs 10.8 +/- 8.4 min, respectively; p < 0.001). Multiple logistic regression adjusted for age, sex, comorbid status, diagnosis (ie, neurocritical vs other), and severity of illness revealed that neurocritical disease (odds ratio [OR], 7.6; p < 0.02) and RT50%DeltaVe (OR, 1.7; p < 0.01) were independent predictors of extubation outcome. The area under the receiver operating characteristic curve for the predictive model was 0.89 (95% confidence interval, 0.81 to 0.96). CONCLUSION: Determination of the RT50%DeltaVe at the bedside may be a useful adjunct in the decision to extubate, with better results found in nonneurocritical patients.

Liver dysfunction associated with artificial nutrition in critically ill patients.

INTRODUCTION: Liver dysfunction associated with artificial nutrition in critically ill patients is a complication that seems to be frequent, but it has not been assessed previously in a large cohort of critically ill patients. METHODS: We conducted a prospective cohort study of incidence in 40 intensive care units. Different liver dysfunction patterns were defined: (a) cholestasis: alkaline phosphatase of more than 280 IU/l, gamma-glutamyl-transferase of more than 50 IU/l, or bilirubin of more than 1.2 mg/dl; (b) liver necrosis: aspartate aminotransferase of more than 40 IU/l or alanine aminotransferase of more than 42 IU/l, plus bilirubin of more than 1.2 mg/dl or international normalized ratio of more than 1.4; and (c) mixed pattern: alkaline phosphatase of more than 280 IU/l or gamma-glutamyl-transferase of more than 50 IU/l, plus aspartate aminotransferase of more than 40 IU/l or alanine aminotransferase of more than 42 IU/l. RESULTS: Seven hundred and twenty-five of 3,409 patients received artificial nutrition: 303 received total parenteral nutrition (TPN) and 422 received enteral nutrition (EN). Twenty-three percent of patients developed liver dysfunction: 30% in the TPN group and 18% in the EN group. The univariate analysis showed an association between liver dysfunction and TPN (p < 0.001), Multiple Organ Dysfunction Score on admission (p < 0.001), sepsis (p < 0.001), early use of artificial nutrition (p < 0.03), and malnutrition (p < 0.01). In the multivariate analysis, liver dysfunction was associated with TPN (p < 0.001), sepsis (p < 0.02), early use of artificial nutrition (p < 0.03), and calculated energy requirements of more than 25 kcal/kg per day (p < 0.05). CONCLUSION: TPN, sepsis, and excessive calculated energy requirements appear as risk factors for developing liver dysfunction. Septic critically ill patients should not be fed with excessive caloric amounts, particularly when TPN is employed. Administering artificial nutrition in the first 24 hours after admission seems to have a protective effect.

[Importance of invasive candidiasis in critical non-neutropenic patients]. / Importance of invasive candidiasis in critical non-neutropenic patients.

Invasive candidiasis (IC) is the most frequent fungal infection in high risk patients in intensive care setting. IC is associated with high attributable mortality and increased healthcare cost. In this review current, epidemiological, diagnostic and clinical management is updated and discussed in the critically ill non netropenic patient.

[Prevention of invasive candidiasis in the critically ill non neutropenic patient]. / Medidas de prevención de la candidiasis invasora en el paciente crítico no neutropénico.

Prevention of invasive candidiasis (IC) in the setting of critically ill non neutropenic patients should be based on evidenced-based recommendations, namely improved hand hygiene, optimal catheter care, and rational and reduced use of broad-spectrum antibiotics. Concomitant interventions aimed at reducing risk factors are important to decrease IC.

[Systemic antifungals. Pharmacodynamics and pharmacokinetics]. / Antifúngicos sistémicos. Farmacodinamia y farmacocinética.

Invasive fungal infections are important causes of morbidity and mortality in critically ill non neutropenic patients. For many years, amphotericin B and flucytosine have been the only available antifungal agents for invasive fungal infections. Fortunately, the antifungal armamentarium has increased during the past two decades with the addition of several new agents. In addition to itraconazole and fluconazole, lipid formulations of amphotericin B, voriconazole, and caspofungin have been recently licensed. These various antifungal agents differ in their pharmacokinetic and pharmacodynamic profile.

Importancia de la candidiasis invasora en el enfermo crítico no neutropénico / Importance of invasive candidiasis in critical non neutropenic patients

La candidiasis invasora (CI) es la infección fúngica más frecuente en enfermoscríticos, asociándose a una elevada mortalidad y costes económicos. En estenúmero monográfico se presenta una revisión actualizada sobre los aspectosepidemiológicos, diagnósticos y de manejo clínico en los pacientes críticos noneutropénicos

Invasive candidiasis (IC) is the most frequent fungal infection in high risk patientsin intensive care setting. IC is associated with high attributable mortality andincreased healthcare cost. In this review current, epidemiological, diagnostic andclinical management is updated and discussed in the critically ill non neutropenicpatient

Medidas de prevención de la candidiasis invasora en el paciente crítico no neutropénico / Prevention of invasive candidiasis in the critically ill non neutropenic patient

La prevención de la candidiasis invasora (CI) en el enfermo crítico no neutropénicodebe sustentarse en recomendaciones basadas en la evidencia: medidashigiénicas de manos; optimización en los cuidados de catéteres vasculares centralesy utilización racional de antibióticos de amplio espectro. Otras intervencionesconcomitantes con la finalidad de disminuir los factores de riego sonimportantes para reducir la incidencia de la CI

Prevention of invasive candidiasis (IC) in the setting of critically ill non neutropenicpatients should be based on evidenced-based recommendations, namelyimproved hand hygiene, optimal catheter care, and rational and reduced use ofbroad-spectrum antibiotics. Concomittant interventions aimed at reducing riskfactors are important to decrease IC

Antifúngicos sistémicos. Farmacodinamia y farmacocinética / Systemic antifungals. Pharmacodynamia and pharmacokinetics

Las infecciones fúngicas invasoras producen una elevada morbimortalidad enlos pacientes críticos no neutropénicos. Durante muchos años, la anfotericina By flucitosina han sido los únicos antifúngicos disponibles para el tratamiento deeste tipo de infecciones. Afortunadamente, el arsenal terapéutico de antifúngicosse ha ampliado en las dos últimas décadas con la aparición de nuevos antimicóticos:itraconazol, fluconazol, fórmulaciones lipídicas de anfotericina B, voriconazoly caspofungina, ya comercializados. Estos antifúngicos difieren en suespectro farmacocinético y farmacodinámico

Invasive fungal infections are important causes of morbidity and mortality in criticallyill non neutropenic patients. For many years, amphotericin B and flucytosinehave been the only available antifungal agents for invasive fungal infections.Fortunately, the antifungal armamentarium has increased during the past twodecades with the addition of several new agents. In addition to itraconazole andfluconazole, lipid formulations of amphotericin B, voriconazole, and caspofunginhave been recently licensed. These various antifungal agents differ in their pharmacokineticand pharmacodynamic profile

Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study.

We investigated the effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity and mortality in critically ill patients who developed systemic inflammatory response syndrome after an acute event. Eleven intensive care units in tertiary-care hospitals participated in a prospective, randomized, single blind, multicenter trial. Eighty-four patients with systemic inflammatory response syndrome of any etiology were randomly allocated to receive a glutamine-enriched enteral diet or a control diet without glutamine.Most patients received the planned caloric intake. The number of infected patients was smaller in the glutamine group than in the control group (11 versus 17 patients, P < 0.05), with a relative risk of 0.5 (95% confidence interval = 0.3-0.9). The most frequent infection was nosocomial pneumonia, with 11 (33%) patients in the control group and 6 (14%) in the glutamine group. There were no differences with respect to other infections, mortality, or length of stay. Intestinal permeability as assessed by the lactulose-mannitol test was unchanged in both groups.Glutamine-enriched enteral diets can decrease nosocomial infections in patients with systemic inflammatory response syndrome.