1.
Angew Chem Int Ed Engl
; 60(20): 11211-11216, 2021 05 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33683807
RESUMEN
A novel method for the concise synthesis of cyclohepta[b]indoles in high yields was developed. The method involves a visible-light-induced, photocatalyzed [2+2]-cycloaddition/ retro-Mannich-type reaction of enaminones. Experimental and computational studies suggested that the reaction is a photoredox process initiated by single-electron oxidation of an enaminone moiety, which undergoes subsequent cyclobutane formation and rapidly fragmentation in a radical-cation state to form cyclohepta[b]indoles.