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Introduction Hypertension (HTN) is considered one of the most frequent life-threatening noncommunicable illnesses. Because HTN has a significant public health impact on cardiovascular health status and healthcare systems in India, it is critical to study Indian clinicians' approaches to HTN management. Methodology This was a cross-sectional, multicentric, non-interventional, and single-visit study that aimed to gather data from across India and examine sociodemographic characteristics and clinician treatment choices in the management of HTN in Indian individuals. As a result, building an information platform about HTN is critical to preventing and controlling this growing burden. Results A total of 5298 patients were recruited in the study from 1061 study centers across India. Among the study patients, 66.67% were females with a mean age of 53.95 ± 14.4, and 66.28% of hypertensive patients presented comorbidities. Among the known risk factors for HTN, 2227 (44.5%) were smokers, while 2587 (51.7%) had sedentary lifestyles. A family history of HTN in either one or both parents was seen in 1076 (21.50%) patients. In management, 40.40% of patients were on anti-hypertensive monotherapy. Amlodipine (41.8%) in monotherapy and amlodipine + metoprolol (32.34%) in combination therapy were the most commonly prescribed antihypertensive. Conclusion Management of HTN can be improved by imparting patient education and awareness about the need for medication compliance, lifestyle modifications, and regular follow-up clinic visits.
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OBJECTIVE: Nimesulide has been evaluated in numerous clinical studies in the management of a variety of acute painful conditions. However, there is limited Indian data available on the nimesulide/paracetamol fixed drug combination (FDC). Hence, an open-label prospective multicentric study was conducted to evaluate the safety and efficacy of this FDC in the management of acute painful conditions in real-world settings. MATERIALS AND METHODS: A prospective, open-label, and multicenter study conducted at 24 centers across Indian patients with acute painful conditions due to trauma, tendinitis, myalgia, low backache, sprains, pulled muscle, soft tissue injury, dental pain, and dental procedure/surgery. Nimesulide/paracetamol FDC was prescribed by clinicians as a part of routine practice. The effectiveness was evaluated on the numerical rating scale (NRS), that is, pain intensity at rest and movement, and the physician/patient global assessment scale (GAS) among the subgroups of acute painful conditions like myalgia, dental pain, low backache, etc. Hepatic safety was also evaluated among the subgroups at the end of treatment. RESULT: A total of 464 patients were included in the study. The reduction in NRS score at rest and movement during treatment duration across different types of pain was statistically significant (p < 0.001). Pain reduction was evident as per patient and physician GAS at the end of treatment in all indications. No clinically significant difference was found in liver parameters at the end of the study. Nimesulide/paracetamol (FDC) was well tolerated across all the subgroups. CONCLUSION: Nimesulide/paracetamol FDC was found to be well-tolerated and effective in pain management across all acute painful conditions in a real-world setting without any hepatic safety concerns.
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Dolor Agudo , Dolor de la Región Lumbar , Humanos , Acetaminofén/uso terapéutico , Antiinflamatorios no Esteroideos/uso terapéutico , Dolor Agudo/tratamiento farmacológico , Dolor Agudo/inducido químicamente , Mialgia , Estudios Prospectivos , Estudios de Cohortes , Combinación de MedicamentosRESUMEN
In 2021 an estimated 74 million individuals had diabetes in India, almost all type 2 diabetes. More than half of patients with diabetes are estimated to be undiagnosed and more 90% have dyslipidemia that is associated with accelerated development of atherosclerotic cardiovascular disease (ASCVD). Patients of Indian descent with diabetes have multiple features that distinguish them from patients with diabetes in Western populations. These include characteristics such as earlier age of onset, higher frequency of features of the metabolic syndrome, more prevalent risk factors for ASCVD, and more aggressive course of ASCVD complications. In light of the unique features of diabetes and diabetic dyslipidemia in individuals of Indian descent, the Lipid Association of India developed this expert consensus statement to provide guidance for management of diabetic dyslipidemia in this very high risk population. The recommendations contained herein are the outgrowth of a series of 165 webinars conducted by the Lipid Association of India across the country from May 2020 to July 2021, involving 155 experts in endocrinology and cardiology and an additional 2880 physicians.
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Aterosclerosis , Cardiología , Enfermedades Cardiovasculares , Diabetes Mellitus Tipo 2 , Dislipidemias , Humanos , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/epidemiología , Factores de Riesgo , Dislipidemias/complicaciones , Dislipidemias/epidemiología , Dislipidemias/terapia , Aterosclerosis/complicaciones , Aterosclerosis/terapia , Lípidos , India/epidemiologíaRESUMEN
Patients with acute coronary syndrome (ACS) have a high risk of subsequent adverse cardiovascular outcomes, particularly within the first 30 days. Although it is well documented that initiation of statin therapy in the setting of ACS improves short- and long-term cardiovascular outcomes, and achievement of lower levels of low density lipoprotein cholesterol (LDL-C) incrementally improves outcomes, many patients with ACS have persistent hypercholesterolemia after discharge from the hospital. This is a missed opportunity that prompted the Lipid Association of India to develop recommendations for earlier initiation of more aggressive LDL-C lowering treatment, particularly for patients of South Asian descent who are well-documented to have earlier onset of more aggressive atherosclerotic cardiovascular disease. The Lipid Association of India recommends individualized aggressive LDL-C goals after ACS, which can be rapidly achieved with high intensity statin therapy and subsequent goal-directed adjunctive treatment with ezetimibe and PCSK9 inhibitors. Improved treatment of hypercholesterolemia achieved within weeks after ACS has the potential to reduce the high rate of morbidity and mortality in these high risk patients.
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Síndrome Coronario Agudo , Anticolesterolemiantes , Inhibidores de Hidroximetilglutaril-CoA Reductasas , Hipercolesterolemia , Hiperlipidemias , Síndrome Coronario Agudo/tratamiento farmacológico , Anticolesterolemiantes/efectos adversos , LDL-Colesterol , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Hipercolesterolemia/inducido químicamente , Hipercolesterolemia/tratamiento farmacológico , India , Proproteína Convertasa 9RESUMEN
INTRODUCTION: Healthcare is probably the last frontier that Artificial Intelligence (AI) has not conquered. Cultural factors significantly impact the way healthcare is accessed and delivered. Affordability, educational and social status, physician training, lack of physician talent in difficult to serve areas all contribute to this. Cultural perspectives of clinicians and clinical habits during the human-computer interaction and inherent suspicion of lack of human to human interaction contribute to perceptions of inhibition in the adoption of AI in routine medical practice. In this paper we examine whether measurable cultural dimensions would impact the adoption of AI in routine clinical practice. MATERIALS AND METHODS: Qualified Medical Professionals (n=206) were chosen randomly and an online secure survey was conducted consisting of 26 questions. 83% of respondents were from different parts of India, remaining 17 % from other countries like USA, Canada, UK, UAE, Oman, Zambia, Nigeria, Bangladesh, Vietnam and Japan. We defined four different cultural dimensions inspired by Hofstede's cultural dimension theory and one dimension based on attitudes of clinicians towards technology in general. We measured the following: Compliance distance (the degree of adherence to evidence based standards) Collectivism vs Individualism (the sense of belonging to a group) Long term vs Short term orientation (the idea of planning and thinking long term) Uncertainty Avoidance (the degree of tolerance to uncertainty) Technology Friendliness (the degree to which technology is perceived as being helpful) Results: We found that there were no differences in adoption of AI in clinical practices based on compliance, collectivism, and long term orientation. However, we found a correlation between the requirement for a face to face consultation (high uncertainty avoidance) and Non-adoption of AI. The results demonstrate that uncertainty avoidance hinder the acceptance of technology like telemedicine and AI alike. There were also no major differences in the adoption of AI based on any geographical variation, specialty or practice sector on the adoption of AI. Notably, tech savviness or technology friendliness did not affect the adoption of AI. We conclude that any useful AI technology which gives validated results could be adopted by clinicians in general and has potential to become a good screening measure in areas with poor healthcare access. CONCLUSION: Of the many cultural dimensions we studied, the only dimension that seemed to have an impact on the adoption of any technology including AI was the high uncertainty avoidance. Other dimensions did not impact the adoption of AI.
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Inteligencia Artificial , Médicos , Atención a la Salud , Humanos , Estatus Social , Encuestas y CuestionariosRESUMEN
AIMS AND OBJECTIVES: To study the incidence,risk factors and in hospital mortality of Type I Cardiorenal syndrome(CRS1). To study the incidence of hyperkalemia in patients receiving Acei, ARB's or MRA Materials and Methods: Prospective observational cohort study done between June and December 2015 in Madras Medical Mission, Chennai. Consecutive patients admitted with ACS/ADHF were studied and clinical, biochemical and laboratory data was collected. The development of CRS1 was determined by KDIGO criteria. Statistical analysis was done using IBM SPSS version 21. RESULTS: Among 460 patients studied, 153 (34%) developed CRS 1 according to KDIGO criteria. The number of diabetics and patients with pre-existing CKD was significantly higher in the CRS 1 group (p=0.00). Mortality was significantly higher in the CRS 1 group (20.2% vs. 7.8% p=0.00). The presence of CKD, Diabetes mellitus, inotropic requirement and eGFR, 60 ml/min/1.73 m2 were significant predictors of CRS 1. Among patients with CRS1, 55 patients (23.5%) needed renal replacement therapy (15.6 % acute peritoneal dialysis, 20.2% SLED). There was no significant difference in the incidence of hyperkalemia in patients who were on prior Acei, ARBs and MRA. CONCLUSION: There is a high incidence of CRS 1 in our setting and the mortality is significantly higher in this group of patients. Early nephrology referral and prompt stoppage of nephrotoxic agents can significantly reduce the incidence and risk of CRS1.
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Síndrome Cardiorrenal , Antagonistas de Receptores de Angiotensina , Inhibidores de la Enzima Convertidora de Angiotensina , Síndrome Cardiorrenal/epidemiología , Síndrome Cardiorrenal/terapia , Humanos , India/epidemiología , Estudios Prospectivos , Factores de Riesgo , Atención Terciaria de SaludRESUMEN
Background: High blood pressure (BP) is the largest contributor to the global burden of disease and mortality. This Blood Pressure screening program was initiated in conjunction with the May Measurement Month to increase the awareness of the importance of BP and also designed to understand the problems of real time clinical situations. Methodology: This was a cross sectional, multicentric, non-interventional, observational and single visit study. The study was conducted in the Outpatient department of many clinics/ institutions. The convenience sampling technique was used to select the centers in this study and obtain the geographical distribution of India. Results: A total of 1,36,095 BP screening forms were considered for analysis. A total of 37,017 subjects (27.2%) had BP of >130/80 mm Hg. Among participants, 44.5% of men in age group of 51 60 years had high BP. 31.2 % of the women in the age group of 41-50 years had high BP. Among 37017 subjects, 14066 subjects (38%) were newly diagnosed subjects with hypertension. In the subset (N=22,951) of known cases of hypertension, Men were 14, 127 (Urban, N=7488 and Rural, N=6639) and 8824 were women (Urban, N=4588 and Rural, N=4236). The common comorbidities were dyslipidemia, cardiovascular disorders and diabetes. Conclusion: Despite the advances in hypertension management and emphasis on patient education, our study shows that hypertension continues to be a significant health burden. Improving patient compliance to lifestyle modifications, medication and regular follow-up clinic visits by imparting patient education and awareness can provide better results in Hypertension management.
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Hipertensión , Adulto , Presión Sanguínea , Femenino , Humanos , Hipertensión/diagnóstico , Hipertensión/epidemiología , India/epidemiología , Masculino , Tamizaje Masivo , Persona de Mediana Edad , Población RuralAsunto(s)
Apolipoproteínas B , Enfermedades Cardiovasculares , HDL-Colesterol , Humanos , Factores de RiesgoRESUMEN
OBJECTIVE: Hypertension and Diabetes are considered as two leading risk factors of mortality in the world. According to an ICMR-INDIAB study, prevalence of hypertension in Tamil Nadu was higher in urban population than the rural population. Hence this study was planned to estimate the prevalence and distribution of hypertension among the urban poor with and without diabetes. METHODS: A community based cross-sectional study was conducted among two backward communities in North Chennai, Tamil Nadu. A total of 330 participants with and without diabetes, were recruited after screening 1272 subjects and self reported diabetes cases of 235. Measurement of blood pressure was done in both groups based on American Heart Association (AHA) criteria and diagnosis of diabetes was made based on the previous history of diabetes and WHO criteria. RESULTS: Prevalence of hypertension (Stage II) among the people with diabetes and without diabetes was reported 44.8%, and 42.6% respectively (p= 0.046). Obesity and overweight were significantly associated with prevalence of hypertension among people with diabetes (p= 0.021). Distribution of stage II hypertension among males and females were 46.2% and 42.80% respectively. There was significant gender difference in the prevalence of HTN (p = 0.043). CONCLUSION: Prevalence of hypertension was found to be higher among the diabetic group compared to the non- diabetic group (44.8% vs 42.6%), though the difference between the two was not very substantial. We therefore conclude that half of the urban poor are hypertensive even if they are not diabetic.
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Diabetes Mellitus , Hipertensión , Estudios Transversales , Diabetes Mellitus/epidemiología , Femenino , Humanos , Hipertensión/complicaciones , Hipertensión/epidemiología , India/epidemiología , Masculino , Prevalencia , Factores de Riesgo , Población Rural , Población UrbanaRESUMEN
Objective: This study is aimed at analyzing the clinical symptomatology and hematological evaluation with an emphasis on platelet indices in relation to predicting the outcome of the febrile thrombocytopenic patients admitted in Coimbatore medical college hospital.. Methods: This is a prospective study involving 100 adult patients who presented to our hospital with fever and thrombocytopenia (platelet <1,50,000). This study excluded patients with known causes of thrombocytopenia like ITP and patients on chemotherapy etc. Results: Out of 100 patients 34 were dengue positive, 66 were dengue negative. Dengue specific symptoms like myalgia and retro-orbital pain were present in 58.88% of dengue positive and 10.60% of dengue negative patients. Laboratory evaluation revealed sharp rise in hematocrit with fall in platelet count in both the groups more significant in dengue positive group. Bleeding manifestation and rashes were 29.4% and 26.4% in dengue positive, 12.12% and 7.57% in dengue negative group respectively. MPV was significantly lower in patients with bleeding manifestations irrespective of platelet count in both the groups. Mortality in our study was 2%. Conclusion: MPV is an independent predictor of bleeding manifestation and poor outcome. Dengue virus may suppress the bone marrow as evidenced by alteration in MPV in addition to other mechanisms of thrombocytopenia.
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Trombocitopenia , Dengue , Fiebre , Humanos , Estudios Prospectivos , Centros de Atención TerciariaAsunto(s)
Anemia/complicaciones , Síndrome Metabólico/complicaciones , Anemia/etiología , Anemia/terapia , Complicaciones de la Diabetes/etiología , Dislipidemias/complicaciones , Femenino , Hemoglobina Glucada/análisis , Homeostasis , Humanos , Hipoglucemiantes/administración & dosificación , Hipoglucemiantes/efectos adversos , Hierro/metabolismo , Enfermedad del Hígado Graso no Alcohólico/complicaciones , Obesidad/complicaciones , Enfermedades Vasculares Periféricas/complicaciones , Síndrome del Ovario Poliquístico/complicacionesRESUMEN
Pharmacovigilance is the art and science of detection, understanding and prevention of adverse drug reactions and not merely a critical analysis of prescriptions and errors. This field starts with reporting by clinicians of a suspected adverse drug reaction (ADR) to the pharmacologist followed by joint causality analysis and ends at the application of new information by a clinician for benefit of patients. There are a number of ways, which can be utilised for reporting adverse effects using pen and paper format to software applications for smart phones. Varied types of activities spreading from systematic reviews to the mechanistic evaluation of ADR can be performed under the umbrella of pharmacovigilance. It is of utmost importance for clinicians to understand how to identify, communicate and understand adverse effects of drugs with an aim to prevent harm to patients.