[Neurohumoral changes in patients with mild and moderate forms of hypertension under the influence of losartan]. / Neirogumoral'nye izmeneniia u bol'nykh s miagkoi i umerennoi formami gipertonicheskoi bolezni pod vliianiem lozartana.

The article presents data on effects of losartan (Cozaar of the Merck-Sharp-Dohme firm, USA) on neurohumoral indices in patients with mild to moderate forms of hypertension. Apart from optimum hypotensive effect and modulating influence on morphofunctional parameters of the heart losartan was found to be endowed with a broad spectrum of neurohumoral effects (reduction in the ejection of catecholamines, natriuretic hormone, stabilization of indices for the renin-angiotensin system etc.). Moreover, the given drug preparation does not have appreciable effect on the activity of the kallikrein-kinin system, by which property it differs favourably from angiotensin-converting enzyme inhibitors.