ABSTRACT: The presence of neoplastic melanocytes within the eccrine apparatus into the reticular dermis and/or subcutaneous tissue is extremely rare. The staging of syringotropic melanomas and their biological behavior are still controversial. We present 6 new cases of syringotropic melanoma and their main histopathologic features; review the previous literature; and discuss about the origin, staging, and prognosis of this rare variant of melanoma.
Melanocytes/pathology , Melanoma/pathology , Skin Neoplasms/pathology , Sweat Glands/pathology , Aged , Aged, 80 and over , Biomarkers, Tumor/analysis , Biopsy , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Male , Melanocytes/chemistry , Melanoma/chemistry , Melanoma/surgery , Middle Aged , Predictive Value of Tests , Skin Neoplasms/chemistry , Skin Neoplasms/surgery , Sweat Glands/chemistry , Sweat Glands/surgery , Treatment Outcome
Toker cells (TCs) are sometimes present in the nipple epidermis as oval cells with pale cytoplasm and roundish nuclei. In most cases, TCs may be easily distinguished from cancerous cells of Paget disease of the nipple (PCs). Especially in TC hyperplasia, in which mild-to-moderate atypia may be present, it may be challenging to distinguish between TCs and PCs. The combination of chronic inflammatory changes in the nipple, in the context of Zuska disease, and TC hyperplasia, may easily lead to an erroneous diagnosis of mammary Paget disease.
Abscess/diagnosis , Abscess/pathology , Breast Diseases/diagnosis , Breast Diseases/pathology , Fistula/diagnosis , Fistula/pathology , Nipples/pathology , Adult , Breast Neoplasms/pathology , Diagnosis, Differential , Female , Humans , Hyperplasia/diagnosis , Hyperplasia/pathology , Paget's Disease, Mammary/pathology , Smoking/adverse effects
Eosinophilia/diagnosis , Exanthema/diagnosis , Leukemia, Myeloid, Acute/complications , Paraneoplastic Syndromes/diagnosis , Pruritus/diagnosis , Administration, Cutaneous , Administration, Oral , Biopsy , Eosinophilia/drug therapy , Eosinophilia/immunology , Eosinophilia/pathology , Exanthema/drug therapy , Exanthema/immunology , Exanthema/pathology , Female , Glucocorticoids/administration & dosage , Humans , Leukemia, Myeloid, Acute/immunology , Middle Aged , Paraneoplastic Syndromes/drug therapy , Paraneoplastic Syndromes/immunology , Paraneoplastic Syndromes/pathology , Pruritus/drug therapy , Pruritus/immunology , Pruritus/pathology , Skin/immunology , Skin/pathology , Treatment Outcome
BACKGROUND: Non-neural granular cell tumor (NNGCT) is an uncommon neoplasm of controversial histogenesis and its histopathologic differential diagnosis includes, in addition to conventional GCT, other dermal tumors that may exhibit granular cell change. METHODS: Three patients with a diagnosis of NNGCT were identified in the authors' files. Hematoxylin and eosin-stained sections and immunohistochemical studies were performed. RESULTS: Histopathological study of the three lesions showed dermal proliferation of granular cells arranged in thick fascicles between collagen bundles. The lesions showed positivity for Factor XIIIa, CD163, CD68, NKIC3, vimentin, ALK, fascin, and cyclin D1. CONCLUSION: To our knowledge, positivity for cyclin D1 has not been reported to date in NNGCT. In borderline cases, where the diagnosis is unclear despite histopathologic and immunohistochemical findings, positivity for cyclin D1 may favor the diagnosis of NNGCT. Further investigations to assess the differentiation of this rare neoplasm are needed.
Granular Cell Tumor/pathology , Skin Neoplasms/pathology , Adult , Biomarkers, Tumor/analysis , Female , Humans , Immunohistochemistry , Male , Young Adult
