Deep Learning to Obtain Simultaneous Image and Segmentation Outputs From a Single Input of Raw Ultrasound Channel Data.

Single plane wave transmissions are promising for automated imaging tasks requiring high ultrasound frame rates over an extended field of view. However, a single plane wave insonification typically produces suboptimal image quality. To address this limitation, we are exploring the use of deep neural networks (DNNs) as an alternative to delay-and-sum (DAS) beamforming. The objectives of this work are to obtain information directly from raw channel data and to simultaneously generate both a segmentation map for automated ultrasound tasks and a corresponding ultrasound B-mode image for interpretable supervision of the automation. We focus on visualizing and segmenting anechoic targets surrounded by tissue and ignoring or deemphasizing less important surrounding structures. DNNs trained with Field II simulations were tested with simulated, experimental phantom, and in vivo data sets that were not included during training. With unfocused input channel data (i.e., prior to the application of receive time delays), simulated, experimental phantom, and in vivo test data sets achieved mean ± standard deviation Dice similarity coefficients of 0.92 ± 0.13, 0.92 ± 0.03, and 0.77 ± 0.07, respectively, and generalized contrast-to-noise ratios (gCNRs) of 0.95 ± 0.08, 0.93 ± 0.08, and 0.75 ± 0.14, respectively. With subaperture beamformed channel data and a modification to the input layer of the DNN architecture to accept these data, the fidelity of image reconstruction increased (e.g., mean gCNR of multiple acquisitions of two in vivo breast cysts ranged 0.89-0.96), but DNN display frame rates were reduced from 395 to 287 Hz. Overall, the DNNs successfully translated feature representations learned from simulated data to phantom and in vivo data, which is promising for this novel approach to simultaneous ultrasound image formation and segmentation.

Robust Short-Lag Spatial Coherence Imaging.

Short-lag spatial coherence (SLSC) imaging displays the spatial coherence between backscattered ultrasound echoes instead of their signal amplitudes and is more robust to noise and clutter artifacts when compared with traditional delay-and-sum (DAS) B-mode imaging. However, SLSC imaging does not consider the content of images formed with different lags, and thus does not exploit the differences in tissue texture at each short-lag value. Our proposed method improves SLSC imaging by weighting the addition of lag values (i.e., M-weighting) and by applying robust principal component analysis (RPCA) to search for a low-dimensional subspace for projecting coherence images created with different lag values. The RPCA-based projections are considered to be denoised versions of the originals that are then weighted and added across lags to yield a final robust SLSC (R-SLSC) image. Our approach was tested on simulation, phantom, and in vivo liver data. Relative to DAS B-mode images, the mean contrast, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) improvements with R-SLSC images are 21.22 dB, 2.54, and 2.36, respectively, when averaged over simulated, phantom, and in vivo data and over all lags considered, which corresponds to mean improvements of 96.4%, 121.2%, and 120.5%, respectively. When compared with SLSC images, the corresponding mean improvements with R-SLSC images were 7.38 dB, 1.52, and 1.30, respectively (i.e., mean improvements of 14.5%, 50.5%, and 43.2%, respectively). Results show great promise for smoothing out the tissue texture of SLSC images and enhancing anechoic or hypoechoic target visibility at higher lag values, which could be useful in clinical tasks such as breast cyst visualization, liver vessel tracking, and obese patient imaging.