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Bisindole-based small molecules as transmembrane anion transporters and potential anticancer agents.
Org Biomol Chem
; 22(24): 4987-4992, 2024 06 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38832875
RESUMEN
Few synthetic ion transporters have been reported incorporating indole as the core moiety. We have developed a novel bisindole-based transporter capable of efficient transmembrane anion antiport. This system induced cytotoxicity in MCF-7 breast cancer cells via chloride ion homeostasis disruption and the associated ROS generation, mitochondrial membrane depolarization, and lysosomal deacidification.