Efgartigimod-associated Kaposi's varicelliform eruption and herpetic conjunctivitis in a patient with seropositive ocular myasthenia gravis: a case report and review.

Background: Efgartigimod (Efgartigimod alpha fcab, Vyvgart™) is a pioneering neonatal Fc receptor (FcRn) antagonist for the treatment of severe autoimmune diseases mediated by pathogenic immunoglobulin G (IgG) autoantibodies, including myasthenia gravis (MG). It is a well-tolerated drug with minor side effects, such as headache and upper respiratory (lung) and urinary tract infections. Here, we present a case of Kaposi's varicelliform eruption (KVE) and herpetic conjunctivitis related to efgartigimod in a 60-year-old patient with ocular MG (OMG). Case description: A 60-year-old Chinese male suffered from acetylcholine receptor antibody positive (AChR Ab+) OMG for 8 years. During this period, he underwent first-line treatment with systemic corticosteroids, cyclosporine, cyclophosphamide, and so on, but had poor symptom improvement. On the recommendation of his attending neurologist, he received one cycle of intravenous efgartigimod (10mg/kg, once weekly for 4 weeks). The patient experienced fever, widespread painful blisters, and edema on the face on the third day after his last intravenous infusion. The patient also complained of increased secretions and a foreign body sensation in both eyes. Laboratory tests confirmed infection with herpes simplex virus (HSV). A diagnosis of efgartigimod-associated KVE and herpetic conjunctivitis was made. After intravenous administration (5mg/kg, 3 times a day, every 8 hours) for 10 days, the patient was cured without residual complications. Conclusions: This case is the first report of a patient with KVE and herpetic conjunctivitis related to efgartigimod in PubMed. This is rare and unusual. Clinicians should be alert to the rare symptoms related to efgartigimod.

The Chain-Mediating Effects of Mindfulness and Sense of Control on Corporate Employees' Mental Health Problems.

Based on the chain-mediating role of mindfulness and sense of control, this study examines the mediating role of mindfulness and sense of control on employees' mental health. A total of 720 questionnaires were collected from employees of select enterprises and institutions in China; 53 invalid questionnaires were excluded, with a response rate of 93%, leaving 667 employees as the study sample (average age = 38 years, 71.8% female). The study findings show that: (1) Work-family conflict had a significant positive correlation with mental health problems and a significant negative correlation with mindfulness and sense of control. (2) The influence on the mental health state was due to the mediating effect of mindfulness, sense of control, and the chain-mediating effect of mindfulness and sense of control. The study adopted self-report scales for measuring mindfulness and a sense of control; therefore, further experimental methods must be included in the future to explore these results. This study shows that mindfulness and sense of control can reduce the impact of work-family conflict on mental health problems. Additionally, the chain-mediating effect of mindfulness and sense of control plays an important role in mental health problems.

Psychological Benefits of Arts Participation for Emerging Adulthood: A Pathway to Flourishing.

This study examined 430 Chinese college students' engagement in arts activities and the psychological benefits derived from such activities. The research differentiated between various types of arts participation and ways of involvement and examined four potential positive psychological outcomes. The findings revealed correlations between (1) creative participation in the performing arts, 'flow', and aesthetic emotions; (2) consumptive participation in the visual arts and aesthetic emotions; and (3) creative participation in the literary arts and ego identity. Holistic arts participation demonstrated a significantly positive relationship with flourishing. A path analysis showed that flow experience and aesthetic emotions served as mediators in the mechanism through which holistic arts participation affected flourishing, with a chained mediation effect from flow experience to ego identity. This study confirms that arts participation is an effective pathway for individual flourishing and that more diverse and profound engagement in the arts can lead to sustained and widespread happiness.

Enhancement of Peroxydisulfate Activation for Complete Degradation of Refractory Tetracycline by 3D Self-Supported MoS2/MXene Nanocomplex.

Antibiotic abuse, particularly the excessive use of tetracycline (TC), a drug with significant environmental risk, has gravely harmed natural water bodies and even posed danger to human health. In this study, a three-dimensional self-supported MoS2/MXene nanohybrid with an expanded layer spacing was synthesized via a facile one-step hydrothermal method and used to activate peroxydisulfate (PDS) for the complete degradation of TC. The results showed that a stronger •OH signal was detected in the aqueous solution containing MoS2/MXene, demonstrating a superior PDS activation effect compared to MoS2 or Ti3C2TX MXene alone. Under the conditions of a catalyst dosage of 0.4 g/L, a PDS concentration of 0.4 mM, and pH = 5.0, the MoS2/MXene/PDS system was able to fully eliminate TC within one hour, which was probably due to the presence of several reactive oxygen species (ROS) (•OH, SO4•-, and O2•-) in the system. The high TC degradation efficiency could be maintained under the influence of various interfering ions and after five cycles, indicating that MoS2/MXene has good anti-interference and reusability performance. Furthermore, the possible degradation pathways were proposed by combining liquid chromatography-mass spectrometry (LC-MS) data and other findings, and the mechanism of the MoS2/MXene/PDS system on the degradation process of TC was elucidated by deducing the possible mechanism of ROS generation in the reaction process. All of these findings suggest that the MoS2/MXene composite catalyst has strong antibiotic removal capabilities with a wide range of application prospects.

Parent-Child Discrepancies in Perceived Parental Emotion Socialization: Associations with Children's Internalizing and Externalizing Problems in Chinese Families.

Parental emotion socialization is highly associated with children's internalizing and externalizing problems. However, research on parent-child discrepancies in parental emotion socialization perceptions and their relationship with children's developmental outcomes remains limited. This study explores the relationship between parent-child discrepancies in their reports of parental emotion socialization and children's internalizing/externalizing problems in Chinese families. The participants were 390 children (55% girls, Mage = 11.70 years, SDage = 1.17) and their primary caregivers (68% mother, Mage = 39.52 years, SDage = 5.23). A latent profile analysis identified three profiles of parent-child discrepancies in supportive parental emotion socialization and four profiles in non-supportive parental emotion socialization. Children with more negative perceptions of parental emotion socialization than their parents exhibited the most internalizing and externalizing problems. The parent-child perception difference of the supportive dimension connected to internalizing and externalizing problems, while the perception difference of the non-supportive dimension connected only to internalizing problems. These findings advocate for the conceptualization of perceptions of parent-child discrepancies within family dynamics, which may predict children's developmental outcomes.

Multifaceted roles of WRKY transcription factors in abiotic stress and flavonoid biosynthesis.

Increasing biotic and abiotic stresses are seriously impeding the growth and yield of staple crops and threatening global food security. As one of the largest classes of regulators in vascular plants, WRKY transcription factors play critical roles governing flavonoid biosynthesis during stress responses. By binding major W-box cis-elements (TGACCA/T) in target promoters, WRKYs modulate diverse signaling pathways. In this review, we optimized existing WRKY phylogenetic trees by incorporating additional plant species with WRKY proteins implicated in stress tolerance and flavonoid regulation. Based on the improved frameworks and documented results, we aim to deduce unifying themes of distinct WRKY subfamilies governing specific stress responses and flavonoid metabolism. These analyses will generate experimentally testable hypotheses regarding the putative functions of uncharacterized WRKY homologs in tuning flavonoid accumulation to enhance stress resilience.

Short-term exposure to ambient nitrogen dioxide and increased hospitalization burden for depression in China: a multicity analysis.

Evidence for the increased hospitalization burden, including admissions, expenditures and length of hospital stay (LOS) for depression attributable to ambient nitrogen dioxide (NO2) is lacking. We investigated the associations between short-term exposure to ambient NO2 and attributable admissions, hospitalization expenditures and LOS for depression in 57 Chinese cities during 2013-2017 using a well-established two-stage time-series study approach. Short-term exposure to ambient NO2 was associated with significantly increased admissions, hospitalization expenditures and LOS for depression, and the attributable fractions were 6.87% (95% CI: 2.90%, 10.65%), 7.12% (3.01%, 11.04%) and 6.12% (2.59%, 9.50%) at lag02, respectively. The projected total attributable admissions, hospitalization expenditures and LOS for depression related to ambient NO2 at the national level were 23,335 (9,863, 36,181) admissions, 318.70 (134.43, 492.21) million CNY and 539.55 (227.99, 836.99) thousand days during the study period, respectively. Short-term exposure to ambient NO2 is associated with increased hospitalization burden for depression.

The Effect of Regional Factors on the Mental Health Status of Frontline Nurses and Patients With COVID-19 During COVID-19: The Role of Depression and Anxiety.

At the end of 2019, Wuhan, Hubei Province, China, experienced the ravages of Coronavirus disease 2019 (COVID-19). In a few months, infected people rose to tens of thousands. This study aimed to explore the mental health status of military nurse personnel assisting (non-Hubei area) in the fight against COVID-19 and local nurse personnel (in the Wuhan area), as well as the differences in mental health status between nurses and COVID-19 patients that provide a reference basis for psychological crisis intervention. A convenience sampling method was used to select frontline nurses and COVID-19 patients (sample size 1,000+) from two mobile cabin hospitals from January to March 2020. The questionnaire consists of socio-demographic information, Patient Health Questionnaire 9 (PHQ-9), Generalized Anxiety Disorder 7 (GAD-7), General Mental Health Service Questionnaire and Work Intensity and Physical Status Questionnaire. The results showed that depression was present in 117 nurses (19.73%) and 101 patients (23.33%) with PHQ-9 scores >10; anxiety was present in 60 nurses (10.12%) and 54 patients (12.47%) with GAD-7 >10. The anxiety and depression levels of nurses in Wuhan area were higher than those in non-Hubei area. The differences in PHQ-9 and GAD-7 scores were also statistically significant (p < 0.001) when comparing patients from different regions, with anxiety and depression rates of 30.19 and 16.04% in local patients and 16.74 and 9.50% in foreign patients. The comparison between nurses and patients showed that the nurses were more depressed than the patients, while the patients were more anxious. Local nurses in Wuhan had a higher workload intensity than aid nurses (77.72 vs. 57.29%). Over 95% of frontline nurses and patients reported that they had not received any form of psychological counseling before the COVID-19 outbreak. 12.87% (26/194) of frontline nurses in Wuhan had a history of taking hypnotic drugs. However, fewer patients (16/212, 7.55%) took medication than frontline nurses. Anxiety and depression levels were far higher among local nurses and patients in Wuhan than in non-Hubei areas. The nurses had higher levels of depression, while the patients had higher anxiety levels. Providing targeted mental health services to healthcare professionals and patients is necessary when experiencing the impact of a major event.

Factor Structure and Measurement Invariance of the Brief Symptom Inventory-18 Among Chinese Adults.

This study aimed to investigate the factor structure and measurement invariance of the Brief Symptom Inventory-18 (BSI-18) among Chinese adults. A sample comprising 1,839 adults from four cities in Shaanxi province completed the BSI-18 and background information. The best-fitting factor structure model of the BSI-18 was verified by confirmatory factor analyses, and multigroup confirmatory factor analyses were performed to test the measurement invariance. The results indicated that the three-factor bi-factor model fitted the current data best (χ 2 = 468.861, df = 117, CFI = 0.939, TLI = 0.920, RMSEA = 0.040, BIC = 47044.977). The configural, metric, scalar, and strict invariance models all had acceptable model fit indexes across genders, and the configural, metric, scalar invariance models with different living areas and educational levels were all acceptable. Overall, the three-factor bi-factor model of the BSI-18 shows a good fit for use with Chinese adults, making it a viable tool for effectively measuring the mental health of Chinese adults.

Visual expertise modulates baseline brain activity: a preliminary resting-state fMRI study using expertise model of radiologists.

BACKGROUND: visual expertise and experience modulate evoked brain activity in response to training-related stimuli. However, few studies have considered how the visual experience is represented in the resting state brain activity. This study tried to investigate the way visual experience, i.e., visual recognition expertise, modulates baseline brain neuronal activity in the resting state using the model of radiologists. METHODS: The amplitude of low-frequency (< 0.08 Hz) fluctuation (ALFF) was used as the metric of baseline brain activity and a visual expertise model of radiologists to investigated this question. The visual recognition skill enables them to accurately identify pathological information in medical images. After the behavior measurement, a cohort group of radiology interns (n = 22) and a group of matched layperson (n = 22) were selected for inclusion in the study. The resting state functional magnetic resonance imaging (fMRI) scans were performed for all of the subjects. RESULTS: Higher ALFF in the right fusiform gyrus and the left orbitofrontal cortex were observed, and the ALFF in the fusiform gyrus was correlated with the intern radiologists' behavioral expertise(all results corrected for multiple comparisons). CONCLUSIONS: Visual experience modulates the baseline brain activity in both high-level visual cortex and high-order cognitive cortex, indicating the engagement of both top-down and bottom-up facilitation. We provide a novel perspective to how visual experience modulated cortical brain activity by introducing the resting state changes. Also, we propose that our current study may provide novel ideas for the development of new training protocols in medical school.

Evaluation of a Single-Channel EEG-Based Sleep Staging Algorithm.

Sleep staging is the basis of sleep assessment and plays a crucial role in the early diagnosis and intervention of sleep disorders. Manual sleep staging by a specialist is time-consuming and is influenced by subjective factors. Moreover, some automatic sleep staging algorithms are complex and inaccurate. The paper proposes a single-channel EEG-based sleep staging method that provides reliable technical support for diagnosing sleep problems. In this study, 59 features were extracted from three aspects: time domain, frequency domain, and nonlinear indexes based on single-channel EEG data. Support vector machine, neural network, decision tree, and random forest classifier were used to classify sleep stages automatically. The results reveal that the random forest classifier has the best sleep staging performance among the four algorithms. The recognition rate of the Wake phase was the highest, at 92.13%, and that of the N1 phase was the lowest, at 73.46%, with an average accuracy of 83.61%. The embedded method was adopted for feature filtering. The results of sleep staging of the 11-dimensional features after filtering show that the random forest model achieved 83.51% staging accuracy under the condition of reduced feature dimensions, and the coincidence rate with the use of all features for sleep staging was 94.85%. Our study confirms the robustness of the random forest model in sleep staging, which also represents a high classification accuracy with appropriate classifier algorithms, even using single-channel EEG data. This study provides a new direction for the portability of clinical EEG monitoring.

Basic Psychological Needs Satisfaction Mediates the Link between Strengths Use and Teachers' Work Engagement.

Work engagement is a core indicator that reflects the quality of teachers' occupational lives and the development of students, but few studies have explored the connection between strengths use and work engagement of teachers and the mechanisms underlying this relationship. This paper aimed to investigate how the relation of strengths use with work engagement is affected by a teacher's satisfaction of basic psychological needs. For this purpose, 648 teachers in China completed questionnaires. The results revealed that strengths use exhibited a positive correlation with work engagement and needs satisfaction. Furthermore, autonomy, competence, and relatedness satisfaction mediated the effect of strengths use on work engagement for teachers. The results suggest that autonomy, competence, and relatedness satisfaction serve as factors that mediate the effect of strengths use on work engagement. The significance and limitations of the study are discussed.

Short-term exposure to ambient air pollution and risk of daily hospital admissions for anxiety in China: A multicity study.

The potential impact of short-term exposure to ambient air pollution on risk of anxiety remains uncertain. We performed a detailed evaluation based on data from national insurance databases in China. Daily hospital admissions for anxiety disorders were identified in 2013-2017 from the national insurance databases covering up to 261 million urban residents in 56 cities in China. A two-stage time-series study was conducted to evaluate the associations between short-term exposure to major ambient air pollutants, including fine particles, inhalable particles, nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone, and carbon monoxide, and risk of daily hospital admissions for anxiety. Significant associations between short-term exposures to ambient NO2 and SO2 and risk of daily hospital admissions for anxiety were found in the overall analysis. Per 10 µg/m3 increases in NO2 at lag0 and SO2 at lag6 were associated with significant increases of 1.37% (95% CI: 0.14%, 2.62%) and 1.53% (95% CI: 0.59%, 2.48%) in anxiety admissions, respectively. Stronger associations were found in the southern region and patients <65 years for SO2. Short-term exposure to ambient air pollution is associated with increased risk of anxiety admissions, which may provide important implications for promotion of mental health in the public.

Chinese preschoolers' ownership reasoning based on first possession heuristic.

First possession is a common heuristic people use to solve property conflicts. Previous studies examined whether young children judged ownership based on the first possession heuristic and its stability when conflicting with other cues such as labor, but few focused on the effects in the discovery context. In this study, we used two discovery stories which indicate the discovered object was not owned by anyone beforehand and investigated ownership reasoning with the first possession heuristic in Chinese 3- to 6-year-old preschoolers. By pitting the first possession cue against the labor cue, we investigated the stability of the first possession heuristic in young children's ownership reasoning. The results showed that in the condition where there was only the first possession cue, both the younger and older groups used the first possession heuristic to reason about ownership. However, in the labor condition, 5- and 6-year-olds ceased to support the first possessor and turned to assign objects to the laborer, whereas 3-year-old children still insisted on the first possession heuristic (Study 1 and Study 2). Children across four age groups did not assign ownership to the person who just played with the object but did not modify it (Study 2). The results demonstrate that Chinese preschoolers understand the role of first possession in ownership assignment at an early age in the discovery context but the elderly preschoolers do not rely on the first possession cue when there are conflicting cues such as labor.

Positive and Negative Emotion Classification Based on Multi-channel.

The EEG features of different emotions were extracted based on multi-channel and forehead channels in this study. The EEG signals of 26 subjects were collected by the emotional video evoked method. The results show that the energy ratio and differential entropy of the frequency band can be used to classify positive and negative emotions effectively, and the best effect can be achieved by using an SVM classifier. When only the forehead and forehead signals are used, the highest classification accuracy can reach 66%. When the data of all channels are used, the highest accuracy of the model can reach 82%. After channel selection, the best model of this study can be obtained. The accuracy is more than 86%.

Stroop effect in smartphone addiction among college students.

ABSTRACT: Smartphone addiction (SPA) affects an increasing number of college students, but it remains poorly understood. This study aimed to explore the psychological mechanism of the decrease in cognitive control ability from cognitive psychology in students with SPA.The smartphone addition tendency scale (MPATS) was used to identify 64 undergraduates with SPA (MPATS > 45) and 64 sex- and age-matched controls (MPATS < 30).The 2 groups were well matched for age and sex distribution. The RT of the SPA group under the conflict state was 628.2±59.2 ms vs 549.4 ±â€Š44.2 ms under the consistent state (P < .005). The RT of the control group under the conflict state was 707.5 ±â€Š66.4 vs 582.0 ±â€Š39.4 ms under the consistent state (P < .005). Under the conflict state, errors made by the SPA group were 8.7 ±â€Š5.4, and that of the control group was 6.6 ±â€Š3.7 (P < .05). The reaction delay of the SPA group was 25.6 ±â€Š49.2 vs 110.0 ±â€Š41.8 ms (P < .05).Correlation analysis showed a clear positive correlation between SPA and the number of mistakes in the conflict state of the Stroop task.

Influence of Exposure at Different Altitudes on the Executive Function of Plateau Soldiers-Evidence From ERPs and Neural Oscillations.

This study investigates the changes in soldiers' brain executive function at different altitude environments and their relationship with blood oxygen saturation. Stratified sampling was conducted in different altitude 133 active-duty soldiers who were stationed in Weinan (347 m, n = 34), Nyingchi (2,950 m, n = 32), Lhasa (3,860 m, n = 33), and Nagqu (4,890 m, n = 34) for 2 years. The Go/NoGo paradigm with event-related potentials (ERPs) and event-related oscillations (EROs) was used to explore the time and neural oscillation courses of response inhibition. Behavioral results revealed that at the 4,890-m altitude area, the soldiers had the highest false alarm rate, the longest reaction time, and the slowest information transmission rate. The electrophysiological results revealed that NoGo-N2 and N2d decreased with increasing altitude, with significant changes at 3,860 m; the amplitudes of NoGo-P3 and P3d in plateau groups were significantly more negative than the plain and changed significantly at 2,950 m. The results of correlation analysis showed that NoGo-P3 was negatively correlated with altitude (r = -0.358, p = 0.000), positively correlated with SpO2 (r = 0.197, p = 0.041) and information translation rate (ITR) (r = 0.202, p = 0.036). P3d was negatively correlated with altitude (r = -0.276, p = 0.004) and positively correlated with ITR (r = 0.228, p = 0.018). N2d was negatively correlated with ITR (r = 0.204, p = 0.034). The power spectrum analysis of NoGo-N2 and NoGo-P3 showed that the power of δ and θ bands at the plateau area was significantly lower than the plain area and showed a significant step-by-step decrease; the α-band power increases significantly only in the area of 4,890 m. The effect of chronic hypoxia exposure at different altitudes of the plateau on the response inhibition of soldiers was manifested: 3,860 m was the altitude at which the brain response inhibition function decreased during the conflict monitoring stage, and 2,950 m was the altitude at which it dropped during the response inhibition stage. In addition, the soldier's brain's executive function was closely related to SpO2, and a reduction in SpO2 may lead to a decline in response inhibition.

TESOT: a teaching modality targeting the learning obstacles in global medical education.

In higher education, it is a great challenge for instructors to teach international medical students (IMSs) efficiently. These students usually have different learning obstacles and learning style preferences from domestic students. Thus it is necessary to use teaching modalities targeting the specific characteristics of IMSs. Accordingly, we have developed a teaching modality composed of classical teacher-centered approach (TCA), enriched with components of student-centered approach (SCA) and online interactions targeting the learning characteristics of IMSs, which we defined as TESOT (an acronym made of the underlined words' initials). Aside from the online interactions that provide both answers to questions raised by students and guidance throughout a course, this modality contains additional in-classroom components (i.e., pre-lecture quiz, student-led summary, and post-lecture quiz). The effectiveness of this modality was tested in the nervous system module of the Physiology course for IMSs. The final exam scores in the nervous system module in the year taught with TESOT were higher than those earned by students taught with a classical TCA modality in preceding 2 yr. The improvement of teaching effectiveness is attributable to increasing communication, bridging course contexts, and meeting diverse learning style preferences. These results indicate that TESOT as an effective teaching modality is useful for enhancing efficiency of teaching IMSs.

Perceived Stress and Short-Form Video Application Addiction: A Moderated Mediation Model.

Nowadays, short-form video applications have become increasingly popular due to their strong appeal to people, especially among college students. With this trend, the phenomenon of short-form video application addiction (SVA) also become prominent, which is a great risk for individuals' health and adaptation. Against this background, the present study aimed to examine the association between perceived stress and SVA addiction, as well as its mechanism-the mediating role of self-compensation motivation (SCM) and the moderating role of shyness. A total of 896 Chinese college students was recruited to complete a set of questionnaires on perceived stress (PS), SCM, shyness, and short-form video applications. The results show that PS was positively associated with SVA, and SCM partially mediated this association. In addition, both the direct association between PS and SVA and the indirect effect of SCM were moderated by shyness and were stronger for individuals with higher levels of shyness. The results could not only deepen our understanding of the underlying factors of SVA but also provide suggestions for relevant prevention and intervention procedures.

Development of the Social Media Engagement Scale for Adolescents.

This study aimed to develop the Social Media Engagement Scale for Adolescents (SMES-A), and evaluate its reliability and validity. The initial items were collected via open-ended questions, a literature review, and suggestions from psychological experts. A total valid sample of 2519 adolescents participated in this study. The results of the exploratory factor analysis (EFA) indicated that this scale was composed of three factors named affective engagement, behavioral engagement, and cognitive engagement, accounting for 56.01% of the total variance. The confirmatory factor analysis (CFA) confirmed the three-factor model. The affective engagement, behavioral engagement, and cognitive engagement were positively correlated with the criterion variables of objective social media use. The mean intra-correlation coefficients of the three factors were 0.523, 0.451, and 0.512. The Cronbach's alpha coefficients of the affective engagement, behavioral engagement, and cognitive engagement were from 0.709 to 0.804. Their McDonald's omega were 0.805, 0.805, and 0.712, which showed high reliability of this three-factor structure. The test-retest reliability of the three factors were all above 0.68 8 weeks later. Overall, our findings suggested that the SMES-A is a reliable and valid measurement to evaluate social media engagement among Chinese adolescents.