1.
J Pediatric Infect Dis Soc
; 8(4): 365-367, 2019 Sep 25.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30299489
RESUMEN
Limited data exist on intravenous (IV) posaconazole dosing and the risk for hepatotoxicity it confers to children. In this study, we evaluated dosing and resulting trough levels in 10 pediatric patients on IV posaconazole. A therapeutic level in these patients was achieved 95% of the time. We found a median minimum effective dose of 6.55 mg/kg of body weight. No correlation was found between the duration or posaconazole trough level and an increased alanine transaminase level.