1.
Bioorg Med Chem Lett
; 14(14): 3829-33, 2004 Jul 16.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15203171
RESUMEN
A series of bifunctional compounds was prepared consisting of 17beta estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to the estrogen receptor. Linker characteristics were pivotal determinants underlying the ability of the compounds to kill selectively breast cancer cells that express the estrogen receptor.