[Historical aspects of the formation and development of children's health resort medicine in the Samara region]. / Istoricheskie aspekty formirovaniya i razvitiya detskoi kurortnoi meditsiny v Samarskom regione.

Archive documents and sources in scientific electronic databases were analyzed in order to study the historical origins of the health resort business in terms of children's health resort medicine in the Samara government. It has been established that the period of origin and intensive development of balneology for children in the Samara region occurred at the beginning of the 20th century and the first children's sanatoriums began to function thanks to the initiative of the Society of Governmental Physicians for charitable funds of the Samara nobility and merchantry in territories with natural and climatic therapeutic factors, namely Sernovodsky resort, Barboshina glade and Postnikov ravine. A comparative analysis of the dynamics of morbidity structure of children admitted for sanatorium treatment, as well as general education institutions, from which information on the health of school pupils is received, has been conducted over a period of 120 years. Despite the change of years and generations, there is a general concept of sanatorium health improvement of school pupils as a future social and economic pillar of society, with the formation of a healthy generation for both the region and the country in general.

[Aerobic exercise and fatigue indices in rheumatoid arthritis patients in the health resort care setting]. / Aerobnye uprazhneniya i pokazateli ustalosti u bol'nykh revmatoidnym artritom v usloviyakh sanatorno-kurortnogo lecheniya.

Fatigue is one of the most common symptoms of rheumatoid arthritis (RA). There is strong evidence that physical activity is an effective way to reduce fatigue. OBJECTIVE: To evaluate the effectiveness of aerobic exercise (walking) to reduce fatigue in RA patients in the health resort setting. MATERIAL AND METHODS: The study involved 102 female patients with RA (age 54.38±11.3 years, body mass index 20-29 kg/m2, DAS28-ESR ≤3.2, with severe fatigue of VAS ≥50) who received 21 days of health resort treatment. The health-improving and therapeutic complex includes dosed physical activity, aerobic exercises (walking). Visual analog scale (VAS0-100) and Bristol Rheumatoid Arthritis Fatigue Scale-Numerical Rating Scale (BRAF-NRS V2) were used to assess fatigue, and the 50-meter walking test was used to evaluate the functional status of patients. RESULTS: A correlation between walking duration and the number of steps at a distance of 50 m (p<0.001) as well as between these indices and fatigue (p<0.001) was shown. A positive effect of a standard three-week medical rehabilitation program for patients with RA on fatigue NRS severity (p=0.003) and NRS effect (p=0.037), as well as on patients' functional status (reduced time spent on the 50-meter test, p=0.01) was demonstrated. When comparing groups of RA patients with low (group 1, <5000-6000 steps per day) and optimal (group 2, ≥7000-8000 steps per day) aerobic exercise, positive results were noted in the short term (at 3 weeks) (p<0.001). CONCLUSION: Aerobic exercise is a promising intervention for treating fatigue in rheumatoid arthritis patients. Medical rehabilitation in a resort setting is the best starting point to encourage performing regular physical activity, as well as the best way to develop exercise programs tailored to rheumatoid arthritis patients.

[State policy of development of resort business in Russia: legal and organizational aspects, including those in an emergency]. / Gosudarstvennaya politika razvitiya kurortnogo dela v Rossii: pravovye i organizatsionnye aspekty realizatsii, v tom chisle v ekstremal'noi situatsii.

OBJECTIVE: To analyze the normative and regulatory support of the state policy of development of health resort business in Russia and organizational and methodological aspects of its implementation, including those in emergency and coronavirus pandemic. MATERIAL AND METHODS: The following current methods of community hygienic and medical-organizational research were applied: analytical, statistical, best practice study, monographic, etc. Data from state and departmental official sources, statistical books, scientific publications, and other sources were studied. RESULTS: The main normative, regulatory, organizational and methodological aspects of the strategy implementation, developed in accordance with the order of the Government of the Russian Federation «On approval of the development strategy of the health-resort complex of the Russian Federation¼ dated 26.11.18 №2581-p were analyzed. Some discrepancies in the state and departmental statistics of health-resort organizations were found. The nomenclature of the health-resort area was reviewed, and the used term «health-resort treatment¼ was criticized, which does not correspond to the parts of this type of daily practice medical care, unlike the concepts «health-resort care¼ or «health-resort business¼. The article presents the author's vision of the issue of normative and organizational support of health-resort organizations in an emergency such as COVID-19 pandemic since 2020. CONCLUSIONS: It is shown that the national and local experience of coronavirus infection control contributed to the development of a considerable number of federal regulatory documents in a short time frame. The publication describes an analysis and systematic review of the most important documents, including those related to the spa resorts. Addressing the demanding challenges of further development of the country's health-resort complex largely relies on the state of its facilities and resources. However, its objective analysis is hindered by the identified significant discrepancies in the state and departmental statistic data concerning the number of functioning health-resort organizations and its change over time. As opposed to the concept of «health-resort treatment¼, the term «health-resort care¼ most accurately describes its complexity.

[Traditional nutrition and demography in the Arctic zone of Western Siberia].

High requirements for macro- and micronutrients of the organism of a pregnant woman living in the Far North are associated with the influence of extreme factors of high latitudes, and the needs of the mother and the growing fetus. Only the products of the unique food culture of the Arctic people - the Nenets, make it possible to meet the emerging needs. The aim of the work was to study the impact of traditional nutrition on the reproductive health of Nenets women living in the Arctic zone of Western Siberia. Material and methods. 619 indigenous inhabitants (Nenets) of the Yamal, Nadym and Taz districts of the Yamal-Nenets Autonomous Okrug at the age of 18-65 years were examined. The influence of the type of nutrition (traditional or imported products) on reproductive health indicators (the number of pregnancies, the number of children, the number of spontaneous abortions, frequency of gestosis, threats of termination of pregnancy, operative deliveries) for the period 2013-2018 was studied by analyzing official statistics and by questioning of the female population in own research. Results. The consumption of traditional products (venison, local fishery products, at least 3 times a week) by Nenets women was more often accompanied by a normal physiological course of pregnancy and childbirth (75.2 versus 64.2%, χ2=8.7; p=0.003). It led to a 1.5-fold decrease in the frequency of complications during pregnancy (gestosis, the threat of abortion) (χ2=5.8; p=0.01) and a 20% decrease in the frequency of delivery by cesarean section (χ2=16.6; p<0.001). As a result, a family whose diet was dominated by traditional products had a statistically significantly larger number of children (per child). Conclusion. The preservation of the consumption of reindeer and river fishery products by indigenous women will contribute to the sufficient intake of macro- and micronutrients, that will make it possible to gestate and give birth to a healthier generation of the Nenets society.

[The effectiveness of combined laser therapy in patients with trophic leg ulcer and chronic venous insufficiency]. / Effektivnost' kombinirovannoi lazernoi terapii patsientov s troficheskimi yazvami nizhnikh konechnostei na fone khronicheskoi venoznoi nedostatochnosti.

New prospects associated with the use of laser radiation of different wavelengths in the ultraviolet (365 nm) and the green emission spectrum (525 nm) have appeared in recent years. The high prevalence of the trophic leg ulcers necessitates the search for more effective methods of conservative treatment. PURPOSE OF THE STUDY: Development and scientific justification for the low-intensity laser radiation of different wavelengths combined use in patients with trophic leg ulcers and chronic venous insufficiency (CVI). MATERIAL AND METHODS: 102 patients with trophic leg ulcers and CVI were examined. They were divided into 3 equal groups using simple randomization. Patients in the control group received only traditional conservative therapy; comparison group - traditional conservative therapy and an intravenous laser blood irradiation (ILBI) (λ - 635 nm); the main group - traditional conservative therapy and different wavelengths laser therapy (LT) course. RESULTS AND CONCLUSION: A more significant improvement in the clinical condition occurred under the influence of the course application of combined different wavelengths laser therapy in patients with trophic venous leg ulcers. Compared to patients who received traditional conservative therapy and in combination with ILBI 635 nm, the speed of reparative regeneration of trophic ulcers increased, the time for cleansing trophic ulcers from devitalized tissues was reduced. Computer capillaroscopy data showed that the positive effect of laser exposure on all parts of the microcirculation underlies its therapeutic efficacy.

[The influence of chronomagnetic therapy on the parameters of the quality of life in the patients presenting with the diseases of the musculoskeletal system at the balneological and health resort-based stage of the rehabilitative treatment].

UNLABELLED: The methods for the rehabilitative treatment play an important role in the management of the patients presenting with the diseases of the musculoskeletal system. One of these techniques is chronomagnetic therapy. AIM: The objective of the present study was to evaluate the influence of chronomagnetic therapy on the patient's quality of life. PATIENTS AND METHODS: The patients of the main group included 30 ones with osteoarthrosis, 30 with rheumatoid arthritis, 20 with ankylosing spondylitis, 6 with podagric arthritis, 6 with psoriatic arthritis, and 6 others with reactive arthritis. Each of these patients every day underwent 10 sessions of chronomagnetic therapy with the use of the Multimag apparatus («Kasimov Instrumental Plant¼, Ryazan). The patients of the comparison group (20 ones presenting with osteoarthrosis, 27 with rheumatoid arthritis, 15 with ankylosing spondylitis, 4 with podagric arthritis, 4 with psoriatic arthritis, and 4 subjects with reactive arthritis) received the identical chronomagnetotherapeutic treatment under the conditions of the «Vulan¼ balneological health resort located at Gelendzhik, Krasnodar Region. RESULTS: The patients of the main group presenting with osteoarthrosis were characterized by the most pronounced manifestations of the role physical and social behaviour and the associated enhancement of pain intensity. The patients with rheumatoid arthritis exhibited well apparent manifestation of role and emotional functioning as well as enhanced vitality. Positive dynamics of these characteristics (role physical and emotional functioning, vital activity) was documented in the patients of the comparison group presenting with osteoarthrosis, ankylosing spondylitis, and rheumatoid arthritis. In this group, the patients with osteoarthrosis, ankylosing spondylitis, and rheumatoid arthritis experienced the improvement of the major parameters of the quality of life characterizing the physical and mental components of the health status. CONCLUSION: The chronomagnetotherapeutic treatment at the stage of rehabilitation of the patients suffering from the diseases of the musculoskeletal system markedly improves the characteristics of physical health the disturbances of which may lead to the development of psycho-somatic disorders. Chronomagnetic therapy of the patients with the diseases of the musculoskeletal system under the conditions of a balneological health resort proved to be more effective in terms of improvement of the parameters of physical and mental health. The result of the subjective evaluation of the health status in such patients can be used as a marker of the effectiveness of chronomagnetic therapy and an indicator of remission of the disease.

[The legal aspects of health care of children and adolescents in the Russian Federation].

The article considers on the basis of complex analysis becoming and development of public policy of health care of children, legislative and normative acts in area of legal defense of childhood according international recommendations. The study traces adopted on different levels management subordinate acts, strategical and tactical mechanisms of their application in territories and effectiveness of realization. The situations making possible to detect reserves of enhancement of effectiveness of profile official documents are analyzed The aspects concerning future of national medical science.

[The combined application of enhanced external counterpulsation for the rehabilitation of the patients presenting with coronary heart disease].

We have studied the influence of enhanced external counterpulsation (EECP) applied in the combination with gaseous carbon dioxide baths and infrared laser therapy on the dynamics of clinical and functional abnormalities in the patients presenting with coronary heart disease (CHD) including those after surgical myocardial revascularization. The study was conducted on 40 patients of whom 20 suffered from chronic coronary heart disease and FC II-III angina of effort and the remaining 20 ones presented with coronary artery disease following myocardial revascularization (including 5 patients six months after coronary bypass grafting (CBG) and 15 ones three months after translumbar angioplasty (TLAP) in the combination with stenting of the coronary arteries). The study demonstrated that EECP in the combination with gaseous carbon dioxide baths and infrared laser therapy produced anti-ischemic and antianginal effects, stimulated myocardial contractility, contributed to economization of the cardiac activity, increased exercise tolerance, myocardial and coronary reserves. These changes resulted in the improvement of both the psychological status and the quality of life of the patients.

[The influence of general magnetic therapy on the psychological status of the patients presenting with osteoarthrosis].

The present study was designed to estimate the influence of general magnetic therapy on the psychical conditions of 151 patients presenting with degenerative joint diseases including osteoarthritis (OA). It was shown that the application of general magnetic therapy for the rehabilitative treatment of osteoarthrosis promotes the improvement of the psycho-emotional state of the patients. It is concluded that prescription of general magnetic therapy to the patients with OA suffering from serious psycho-emotional disorders brings about beneficial changes in their anxiety- and depression-related personality traits.

Study of Candida albicans strains isolated from women with various forms of vaginal candidiasis.

Adhesive activity of Candida albicans towards vaginal epitheliocytes is hormone-dependent. Two types of C. albicans adhesins sensitive to polyphenyloxidase and asparaginase were detected. Laser irradiation nonspecifically modulated both adhesin types. Population relationships between fungi and lactobacilli in patients with vaginal candidal infection and in C. albicans carriers were studied. Genodiagnostic method for identification of C. albicans and morphogenesis-associated genes of these yeast-like fungi was approved.

[Immobilization of myocardial tropomyosin]. / Immobilizatsiia miokardial'nogo tropomiozina.

Immobilized granulated myocardial tropomyosin with magnetic properties of prolonged period of storage was obtained. Tropomyosin inclusion into granules emulsion polymerisation is 89.5%. The largest amount of protein is extracted from granules after 2-3 days, and later this process is slowed down. Studying temperature effect, the maximum protein output was also shown to be reached after 2-3 days and depends on the temperature. Processing of granules, containing tropomyosin, with a solution with high concentration of hydrogen ions, the same results were obtained as under the influence of temperature. The use of 3 mol potassium rodanide did not show the peak of protein washing out of granules.

[Pseudohypertrophic proximal progressive muscular dystrophy with a malignant course manifesting itself in adolescence]. / Psevdogipertroficheskaia proksimal'naia progressiruiushchaia myshechnaia distrofiia s debiutom v podrostkovom vozraste i zlokachestvennym techeniem.

The authors describe an unique case of progressive muscular dystrophy in four brothers T. The disease was peculiar in its debut in adolescence, localization of muscular atrophies in proximal limbs, pseudohypertrophy of various muscular groups, malignant course of the myodystrophy with concomitant endocrine and metabolic disorders. A primarily muscular nature of the disease was confirmed in electrophysiological and pathological investigation. X-linked recessive inheritance of the progressive muscular dystrophy was supposed in T family. The issues of differential diagnosis, clinical polymorphism and genetical heterogeneity of X-linked recessive progressive muscular dystrophies are discussed.

[Ultrastructure of blood capillaries in vascular plexuses of the lateral ventricles of the human brain]. / Ul'trastruktura krovenosnykh kapilliarov sosudistykh spletenii bokovykh zheludochkov golovnogo mozga cheloveka.

Ultrastructure of the wall of the microcirculatory bed links in the lateral ventricles of the human brain has been studied, as well as their interrelations with neural elements and ependyma. Together with typical morphological structural signs, certain peculiarities are revealed, characterizing organic specificity. Elements, performing function of the blood-brain barrier are determined: epithelium (ependyma), basal membranes, interstitium. A well developed afferent and efferent nervous apparatus of the vascular plexus, evidently, actively participates in regulation of the microcirculatory blood bed and in formation of liquor.

[Effect of hypodynamia on the hemomicrocirculatory bed of the triceps muscle and brachial fascia in the rat]. / Vliianie gipodinamii na gemomikrotsirkuliatornoe ruslo trekhglavnoi myshtsy i fastsii plecha krysy.

By means of amputation of the forearm (the place of the brachial musculus attachment is kept intact) in 30 male rats certain conditions are produced for decreasing force activity in the m. triceps brachii. Anatomical changes in structure and in distribution of links of the hemomicrocirculatory bed (HMCB) are followed in the medial head of the muscle and in the fascia covering it. Time of observations - 1-60 days. The sections of the muscles and some parts of the fascia are impregnated with silver nitrate solution. The greatest changes are observed to occur in the capillary-venular links of the HMCB during the interval of 1.14-4.5 days and are manifested as initial congestion of venous blood in these links. Later (4.5-15.3 and further 60 days) together with stable dilatation of all venous components of the blood bed certain qualitative changes take place in the arteriolar links of the HMCB.

[Functional interrelationships of the sympathetic nervous system and the hypothalamo-hypophyseo-adrenal complex]. / Funktsional'nye vzaimootnosheniia simpaticheskoi nervnoi sistemy i gipotalamo-gipofizarno-adrenalovogo kompleksa.

Adrenal and hypothalamic structure has been studied in mice at functional inhibition of the sympathetic region of the vegetative nerve system by means of antibodies against the nerve growth factor. Routine histological, histochemical, morphometric, electron microscopic and radioautographic methods have been applied. In the experiment the hypothalamic region is in the state of a continuous functional stress which is evident from enlargement of neurons and their nuclei in the macrocellular neurosecretory nuclei of the hypothalamus. The method of radioautography proves increasing activity in synthetic processes taking place in supraoptic, paraventricular and ventromedial nuclei of the hypothalamus and in the medial habenular nucleus of the epithalamus. In 30-day-old mice certain structural changes have been revealed in the adrenals demonstrating an increasing activity in their cortex: blood vessels are dilated, cholesterine, lipid and ascorbic acid granules are not evenly distributed, enzymatic activity in cytoplasm of adrenocorticocytes is increased. Ultramicroscopic destructive and regenerative alterations have no definite zonal specificity, nevertheless they are more pronounced in the fascicular zone. Radioautographic and morphometric investigations demonstrate an increasing functional activity in glomerular and fascicular adrenal zones. Taking into account morphologic demonstration of functional stress in hypophysial adenocytes in the same animals (Molostov O. K., 1974), it is possible to conclude that lesions in the sympathetic system center result in adaptive reaction of the hypothalamo-hypophysial system which, in its turn, produces reactions in the adrenals and in the vascular complex. This interconnection is accompanied by the reaction depending on breaking off direct sympathetic effects in the adrenals and vessels.

[Influence of preliminary conditioning to gravitational overloading and subsequent exposure to a series of extreme factors on the intra-organ blood flow of the intestine]. / Vliianie predvaritel'noi trenirovki k gravitatsionnym peregruzkam i posledovatel'nogo deistviia serii ékstremal'nykh faktorov na vnutriorgannoe krovenosnoe ruslo kishechnika.

The intraorganic blood circulation bed of the intestine was studied in 21 rabbits subjected to training to gravitation stresses (according to special schedules) and then to maximum endurable gravitation stresses, hypokinesia for 4 weeks and repeated stresses of the direction and character similar to those at the beginning of the experiment. The direction of stresses was different: head--pelvis, pelvis--head, chest--back. Injection of the intestine blood vessels with the Gerota's mass followed by clearing after A. M. Malygin, histological staining after Van Gieson and method of luxmetry were used. Preliminary training to stresses considerably prevented anatomical alterations in blood vessels of the intestinal coats. The most favourable morphological picture was observed in the cases when the stress was of ventro-dorsal direction. Blood vessels of the large intestine were more inert in their transformation than those of the small intestine coats.

[Large cell neurosecretory nuclei of the anterior hypothalamus of mice following exposure to antibodies to nerve growth factor]. / Krupnokletochnye neirosekretornye iadra perednego gipotalamusa u myshei pri vozdeistvii antitel k faktoru rosta nervov

Studies of morphology of the secretory hypothalamo-neurohypophyseal system under conditions of inhibition of the function of the peripheral region of the sympathetic nervous system were carried out. Desympathyzation was achieved by administration to newly born animals of antibodies to the factor of growth of nerves. In addition to the survey histological methods, morphometry, autoradiography and spectrophotometric investigations were also used. The aim of the work was to establish with the help of the methods referred to above the functional state of the hypothalamo-neurohypophyseal secretory system (HNSS) under deep immunological desympathyzation of the organism. The data obtained confirm the existence of a functional connection between the peripheral region of the sympathetic nervous system and HNSS. A hypofunctional state of the sympathetic department caused a rise in the functional activity to HNSS--in supraoptic and paraventricular nuclei of the hypothalamus there were observed enlarged neurones and their nuclei; this was accompanied by an intensification of the biosynthesis processes and secretion of neurosecretory material, neurohypophysis containing lesser amounts of neurosecret than in the norm. The rise of the functional activity of HNSS was accompanied by a higher specific hormonal effect upon the periphery (the effect of the hormone on "target"), which was confirmed by manifestations of working hypertrophy of the medullar of kidneys. The reaction of HNSS was apparently mediated through a complex of pathological changes in the organism and was directed at the maintenance of the optimal tonus of vessels and at preservation of homoestasis as a whole.