A study of the effect of propranolol on the central hemodynamics using the polycardiographic method in 90 patients with essential hypertension showed that in 83% of them, disregarding the type of hemodynamics, beta-blocker made a negative chronotropic effect, and in 17% of the patients it increased the heart rate. In the patients with the hyperkinetic circulation the negative inotropic effect of propranolol was noted in 42% of the cases, and in the patients with the eu- and hypokinetic circulation 37.5%. However, the improvement of myocardial contractility expressed in an increase in the cardiac and stroke blood volume, the stroke and cardiac indices, and a decrease in peripheral vascular resistance were found in 24.4% of the total number of patients.
Hemodynamics/drug effects , Hypertension/drug therapy , Propranolol/therapeutic use , Adolescent , Adult , Cardiac Output/drug effects , Female , Heart Rate/drug effects , Humans , Hypertension/physiopathology , Male , Middle Aged , Myocardial Contraction/drug effects , Propranolol/pharmacology , Vascular Resistance/drug effects
