Asunto(s)
Procedimientos Quirúrgicos Dermatologicos/métodos , Recurrencia Local de Neoplasia/epidemiología , Estadificación de Neoplasias , Neoplasias Cutáneas/cirugía , Adulto , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia/diagnóstico , Recurrencia Local de Neoplasia/cirugía , Neoplasia Residual , Estudios Prospectivos , Reoperación , Neoplasias Cutáneas/diagnóstico , Estados Unidos/epidemiologíaRESUMEN
Nodule formation can be a potentially disfiguring adverse event of soft tissue fillers. Limited treatment consensus exists regarding the optimal approach for addressing recurrent and persistent nodules. Here we describe two challenging cases of nodules that developed following injection with Restylane and Juvéderm Voluma. We review suspected pathophysiology and discuss our treatment approach. J Drugs Dermatol. 2018;17(5):580-581.
Asunto(s)
Técnicas Cosméticas/efectos adversos , Rellenos Dérmicos/efectos adversos , Cara , Ácido Hialurónico/análogos & derivados , Envejecimiento de la Piel , Enfermedades de la Piel/diagnóstico , Anciano , Diagnóstico Diferencial , Femenino , Humanos , Ácido Hialurónico/efectos adversos , Inyecciones Subcutáneas , Enfermedades de la Piel/inducido químicamenteAsunto(s)
Deformidades Adquiridas Nasales/cirugía , Neoplasias Nasales/cirugía , Rinoplastia/métodos , Neoplasias Cutáneas/cirugía , Carcinoma de Células Escamosas de Cabeza y Cuello/cirugía , Herida Quirúrgica/cirugía , Anciano , Humanos , Masculino , Cirugía de Mohs/efectos adversos , Deformidades Adquiridas Nasales/etiología , Colgajos Quirúrgicos , Herida Quirúrgica/etiologíaAsunto(s)
Carcinoma Basocelular/cirugía , Obstrucción Nasal/etiología , Neoplasias Nasales/cirugía , Rinoplastia , Colgajos Quirúrgicos , Técnicas de Sutura , Suturas , Anciano , Carcinoma Basocelular/patología , Humanos , Masculino , Cirugía de Mohs/métodos , Neoplasias Nasales/patología , Cuidados Posoperatorios , Calidad de Vida , Respiración , Rinoplastia/efectos adversos , Rinoplastia/métodos , Técnicas de Sutura/efectos adversos , Resultado del TratamientoRESUMEN
A 48 year-old woman with a history of fibroids presents with asymptomatic skin lesions. Biopsy reveals cutaneous leiomyomas and subsequent genetic evaluation confirms the diagnosis of hereditary leiomyomatosis and renal cell cancer. In this report, we review the typical presentation of the syndrome as well as recommendations for surveillance.
Asunto(s)
Neoplasias Renales/diagnóstico , Leiomioma/genética , Leiomiomatosis/diagnóstico , Sarcoma/diagnóstico , Neoplasias Cutáneas/diagnóstico , Neoplasias Uterinas/diagnóstico , Femenino , Humanos , Neoplasias Renales/genética , Leiomioma/diagnóstico por imagen , Leiomioma/patología , Leiomiomatosis/genética , Persona de Mediana Edad , Síndromes Neoplásicos Hereditarios , Sarcoma/genética , Neoplasias Cutáneas/genética , Ultrasonografía , Neoplasias Uterinas/genéticaRESUMEN
Insulin is secreted from the islets of Langerhans in coordinated pulses. These pulses are thought to lead to plasma insulin oscillations, which are putatively more effective in lowering blood glucose than continuous levels of insulin. Gap-junction coupling of ß-cells by connexin-36 coordinates intracellular free calcium oscillations and pulsatile insulin release in isolated islets, however a role in vivo has not been shown. We test whether loss of gap-junction coupling disrupts plasma insulin oscillations and whether this impacts glucose tolerance. We characterized the connexin-36 knockout (Cx36(-/-)) mouse phenotype and performed hyperglycemic clamps with rapid sampling of insulin in Cx36(-/-) and control mice. Our results show that Cx36(-/-) mice are glucose intolerant, despite normal plasma insulin levels and insulin sensitivity. However, Cx36(-/-) mice exhibit reduced insulin pulse amplitudes and a reduction in first-phase insulin secretion. These changes are similarly found in isolated Cx36(-/-) islets. We conclude that Cx36 gap junctions regulate the in vivo dynamics of insulin secretion, which in turn is important for glucose homeostasis. Coordinated pulsatility of individual islets enhances the first-phase elevation and second-phase pulses of insulin. Because these dynamics are disrupted in the early stages of type 2 diabetes, dysregulation of gap-junction coupling could be an important factor in the development of this disease.
