1.
Bioorg Med Chem Lett
; 21(7): 2034-9, 2011 Apr 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21334892
RESUMEN
The pharmacokinetic based optimisation of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed. Compound 24 was found to be a highly potent and selective cannabinoid CB(1) antagonist with high predicted human oral bioavailability.