RESUMEN
Gram-negative bacilli causing infective endocarditis (IE) is rare, even in intravenous drug users. This case report underscores several clinically important aspects of Delftia acidovorans IE: the organism's ability to cause rapid destruction of normal native valves and to cause embolic occlusion of large arteries and its resistance to all aminoglycosides.
Asunto(s)
Delftia acidovorans/aislamiento & purificación , Endocarditis/diagnóstico , Endocarditis/patología , Infecciones por Bacterias Gramnegativas/diagnóstico , Infecciones por Bacterias Gramnegativas/patología , Abuso de Sustancias por Vía Intravenosa/complicaciones , Adulto , Antibacterianos/farmacología , Delftia acidovorans/efectos de los fármacos , Delftia acidovorans/patogenicidad , Farmacorresistencia Bacteriana Múltiple , Endocarditis/microbiología , Infecciones por Bacterias Gramnegativas/microbiología , Humanos , MasculinoRESUMEN
INTRODUCTION: Epidemiologic links between herpes simplex virus type-2 (HSV-2) and hepatitis C virus (HCV) exist but are poorly characterized. Seroprevalence studies of HSV-2 in veteran populations with chronic HCV infection are lacking. METHODS: The authors reviewed the medical histories and results of the HerpeSelect IgG (Focus Diagnostics, Cypress, CA) of 244 HCV-infected male veterans engaged in care. All patients were human immunodeficiency virus negative and >99% defined themselves as heterosexual. RESULTS: Using the manufacturer's recommended cutoff for positive results (>1.1), 51.5% of HCV-infected veterans were seropositive for HSV-2. When increasing the cutoff to >3.5, 38.7% of persons were seropositive for HSV-2. Reports of previous diagnosis with genital ulcer disease (9/213; 4.3%) or genital herpes (4/213; 1.9%) were rare. CONCLUSIONS: HSV-2 infection commonly occurred in the study sample of HCV-infected veterans but was infrequently recognized. Future studies should optimize the use of type-specific serologic screening tests in HCV-infected persons. The high prevalence of HSV-2 in this population merits further investigation into any potential biologic interactions between these common viral infections.
Asunto(s)
Coinfección/epidemiología , Hepatitis C Crónica/epidemiología , Herpes Genital/epidemiología , Adulto , Anciano , Anticuerpos Antivirales/sangre , Estudios de Cohortes , Hepatitis C Crónica/complicaciones , Herpes Genital/complicaciones , Herpes Genital/inmunología , Herpesvirus Humano 2/inmunología , Humanos , Inmunoglobulina G/sangre , Masculino , Persona de Mediana Edad , Mississippi/epidemiología , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Estudios Seroepidemiológicos , VeteranosRESUMEN
Fifty-nine Staphylococcus aureus isolates from one hundred blood cultures containing gram-positive cocci in clusters were identified by conventional methods and the BD GeneOhm StaphSR assay (SR). The SR misidentified three methicillin (meticillin)-resistant S. aureus (MRSA) isolates as methicillin-susceptible S. aureus (MSSA), while one MSSA isolate tested negative for S. aureus. The three MRSA isolates were strains with MREJ types that cannot be detected by the currently available SR.