Anti-ulcer activity of leguminosae plants.

CONTEXT: Ulcer is the most common gastrointestinal disturbance resulting from an inadequate gastric mucosal defense. Several drugs are available in the market to address the disease; however, these drugs are associated with unnecessary side effects. OBJECTIVES: Previous research have confirmed the efficacy of plant extracts for possible treatment of the disease. This research aims to evaluate the anti-ulcer properties of medicinal plants. METHODS: Methanol extracts from the leaves of Intsia bijuga, Cynometra ramiflora, Tamarindus indica, Cassia javanica, Cassia fistula, Bauhini purpurea, Senna spectabilis, Senna siamea and Saraca thaipingensis were evaluated for their anti-ulcer activity using HCl-ethanol as ulcerogen. RESULTS: All extracts showed inhibitory activity with I. bijuga, T. indica, S. spectabilis and S. thaipingensis exhibiting more than 50% inhibition. S. thaipingensis showed the highest activity at 80%. S. spectabilis and S. thaipingensis were partitioned further into hexane, ethyl acetate and aqueous fractions. The aqueous and ethyl acetate fractions of S. spectabilis showed significant increased in its activity while the hexane and ethyl acetate fractions of S. thaipingensis gave higher activity than its aqueous portions. CONCLUSIONS: We conclude that plant extracts are potential sources of new anti-ulcer agents.

Anti-ulcer actviity of leguminosae plants / Atividade anti-úlcera de plantas leguminosas

Context Ulcer is the most common gastrointestinal disturbance resulting from an inadequate gastric mucosal defense. Several drugs are available in the market to address the disease; however, these drugs are associated with unnecessary side effects. Objectives Previous research have confirmed the efficacy of plant extracts for possible treatment of the disease. This research aims to evaluate the anti-ulcer properties of medicinal plants. Methods Methanol extracts from the leaves of Intsia bijuga, Cynometra ramiflora, Tamarindus indica, Cassia javanica, Cassia fistula, Bauhini purpurea, Senna spectabilis, Senna siamea and Saraca thaipingensis were evaluated for their anti-ulcer activity using HCl-ethanol as ulcerogen. Results All extracts showed inhibitory activity with I. bijuga, T. indica, S. spectabilis and S. thaipingensis exhibiting more than 50% inhibition. S. thaipingensis showed the highest activity at 80%. S. spectabilis and S. thaipingensis were partitioned further into hexane, ethyl acetate and aqueous fractions. The aqueous and ethyl acetate fractions of S. spectabilis showed significant increased in its activity while the hexane and ethyl acetate fractions of S. thaipingensis gave higher activity than its aqueous portions. Conclusions We conclude that plant extracts are potential sources of new anti-ulcer agents. .

Contexto A úlcera é o distúrbio gastrointestinal mais comum que resulta de uma inadequada defesa da mucosa gástrica. Vários medicamentos estão disponíveis no mercado para tratar a doença, no entanto, estas drogas podem se associar a efeitos colaterais desnecessários. Objetivos Pesquisas anteriores confirmaram a eficácia de extratos de plantas como possível tratamento da doença. Esta pesquisa teve como objetivo avaliar as propriedades anti-úlcera de plantas medicinais. Métodos Extratos alcoólicos das folhas da Intsia bijuga, Cynometra ramiflora, Tamarindus indica, Cassia javanica, Cassia fistula, Bauhini purpurea, Senna spectabilis, Senna siamea e Saraca thaipingensis foram avaliados pela sua atividade anti-úlcera usando o HCl-etanol como ulcerogênico. Resultados Todos os extratos apresentaram atividade inibitória; I.bijuga, T. Índica, S. spectabilis e S. thaipingensis mostraram mais de 50% de inibição. A S. thaipingensis mostrou a maior atividade, atingindo 80%. S. spectabilis e S. thaipingensis foram divididos mais em hexano, acetato de etila e frações aquosas. As frações aquosas e acetato de etila de S. spectabilis mostraram aumento significativo em sua atividade, enquanto que as frações hexano e acetato de etila de S. thaipingensis resultaram em maior atividade do que em partes aquosas. Conclusões Pode-se concluir que os extratos vegetais são fontes potenciais de novos agentes anti-úlcera. .