[Functional activity of natural killers in viral hepatitis A]. / Funktsional'naia aktivnost' estestvennykh killerov pri virusnom gepatite A.

The direct cytotoxic test with the use of C and neoplastic cells of human myeloleukemia K-562 was employed to examine the activity of natural killers (NK) in 234 patients with viral hepatitis and in 51 healthy subjects as control. It was ascertained that in viral hepatitis, the functional activity of NK was appreciably altered. At the disease onset it tended toward lowering, whereas before the recovery it consistently increased. In cyclic hepatitis, the cytotoxicity rose considerably 2 to 3 weeks after the disease onset. In a mild disease, the growth of the cytotoxicity started much earlier and was pronounced to a greater degree than in conditions of medium severity or in grave states. In lingering hepatitis, the growth of NK cytotoxicity started considerably later than in a cyclic disease. During the first 2-3 weeks of the illness, the patients with lingering hepatitis manifested the enhancement of NK suppression, particularly in conditions of medium severity and in grave states. The correlation between the clinical course of viral hepatitis and the functional activity of NK suggests that NK together with the other factors may play an important role in the pathogenesis of viral hepatitis.

[Autoimmune reactions of the humoral type in viral hepatitis]. / Autoimmunnye reaktsii gumoral'nogo tipa pri virusnykh gepatitakh.

Antibodies against antigens of hepatocyte cell membranes are formed in half the patients with hepatitis A and B in one-third of those with pseudotuberculosis. They occur in the period preceding the patients' convalescence rather than in the acute stage of the disease. The recovery of hepatitis patients in whom liver antibodies formed ensued significantly more rapidly than in persons with no autoantibodies. Antibodies against antigens of hepatocyte cell membranes were detectable in different clinical disease patterns. They did not influence the disease progress and witnessed hepatocyte injuries not only in the icteric but also in scarlatiniform and and abdominal disease patterns.

[Ability to redistribute surface receptors in transplantable cell lines]. / Sposobnost' k pereraspredeleniiu poverkhnostnykh retseptorov u kletok perevivaemykh linii.

The ability of cultured lymphoid, erythroid and fibroblastic cells for ligand-induced redistribution of their surface receptors proved to be lower than that of lymphocytes. The process of surface receptors redistribution can be inhibited by low temperature and sodium azide in all the cells under study. Pretreatment with trypsin increased the ability for redistribution of surface receptors in some types of cultured cells, but had no such effect on lymphocytes. These differences between lymphocytes and cultured cells seem to be due to differences in organization of the surface and contractile systems of the respective cells.

[Symptom dynamics in the surgical treatment of posttraumatic arthrosis deformans of the knee joint]. / Dinamika simptomov pri khirurgicheskom lechenii posttravmati-cheskogo deformiruiushchego artroza kolennogo sustava.

288 cases of posttraumatic deforming arthrosis of the knee-joint were examined. The further postoperative periodic examinations and checking of the late results of the treatment of 171 patients have proved that the symptoms of the disease are mainly due to the disorders in the knee-joint stability. The obtained data suggest the possibility of a secondary inflammatory origin of pain in deforming arthrosis and witness an important role played by the surgical prevention and correction of the joint instability in clinical remission of th disease.