RESUMEN
OBJECTIVES: To qualitatively and quantitatively review the use of melatonin as a topical/systemic formulation for the management of periodontitis. MATERIALS AND METHODS: PubMed; Scopus; and Web of Science databases were searched using the MesH terms "melatonin" and "periodontitis". Title and abstracts were screened to eliminate irrelevant and duplicate articles. The full text data of the screened articles were assessed using the selection criteria. RESULTS: Of 176 identified articles (PubMed-66; Scopus-56; Web of Science-52; Cross-reference-2), only 12 studies qualified to be included in the systematic review. Four studies assessed the independent effect of 1% topical melatonin formulation while 8 articles assessed the adjunctive use of systemic melatonin formulation (1-10 mg) following scaling and root planing (SRP). All studies showed an improvement in periodontal parameters such as pocket depth, clinical attachment loss, periodontal disease index, community periodontal index, gingival bleeding scores, and prognostic marker levels in saliva and serum. A meta-analysis of data from 2 studies revealed that 1-2 mg (systemic) melatonin supplementation reduced pocket depth; although the difference was not statistically significant and hence cannot be interpreted or used for conclusive evidence. Risk of Bias Assessment tool (RoBANS) and Cochrane Collaboration RoB tool elicited a high risk of bias in the included studies. GRADE (recommendation assessment, development, and evaluation) inferred a weak recommendation for the use of melatonin in periodontitis management. CONCLUSIONS: Melatonin supplementation (topical and systemic) in periodontitis patients improved key periodontal parameters including pocket depth and clinical attachment loss. CLINICAL RELEVANCE: Melatonin could be a potential host modulatory agent for periodontitis management; although the data from the present review should be interpreted carefully due to the associated high risk of bias.
Asunto(s)
Carcinoma de Células Escamosas , Transición Epitelial-Mesenquimal , Melatonina , Neoplasias de la Boca , Carcinoma de Células Escamosas/tratamiento farmacológico , Línea Celular Tumoral , Humanos , Neoplasias de la Boca/tratamiento farmacológico , Carcinoma de Células Escamosas de Cabeza y CuelloRESUMEN
"The concept of total wellness recognizes that our every thought, word, and behavior affect our greater health and well-being. And we, in turn, are affected not only emotionally but also physically and spiritually."-Greg Anderson.
Asunto(s)
Infecciones por Coronavirus , Coronavirus , Pandemias , Neumonía Viral , Ansiedad , Betacoronavirus , COVID-19 , Depresión , Brotes de Enfermedades , Personal de Salud , Humanos , Distrés Psicológico , SARS-CoV-2Asunto(s)
COVID-19/complicaciones , COVID-19/diagnóstico , Catepsinas/metabolismo , Furina/metabolismo , Neoplasias de la Boca/complicaciones , Enfermedades Periodontales/complicaciones , Enzima Convertidora de Angiotensina 2/metabolismo , COVID-19/epidemiología , Membrana Celular/metabolismo , Biología Computacional , Humanos , Modelos Teóricos , Neoplasias de la Boca/epidemiología , Enfermedades Periodontales/epidemiología , Distanciamiento Físico , Unión Proteica , Dominios Proteicos , Factores de RiesgoRESUMEN
Paragangliomas, extra-adrenal pheochromocytomas, are rare catecholamine-secreting tumor. A 34-year-old lady admitted with diagnosis of ST elevation acute myocardial infarction with cardiogenic shock. Left ventricular function, severely depressed, returned to normal after initial stabilization. Coronary angiogram was normal. A para-aortic paraganglioma was diagnosed during the patient's work-up with biochemical studies, computed tomography of abdomen and functional radioisotopes imaging and was eventually surgically resected. This case shows that acute myocardial infarction may be the initial manifestation of these neuroendocrine tumors. Hypertensive emergency, much less elevated blood pressure may not be present at time of presentation.
