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Chem Commun (Camb)
; 54(51): 7007-7009, 2018 Jun 21.
Article
En
| MEDLINE
| ID: mdl-29872785
A highly regio- and diastereo-selective ortho-lithiation/addition of anisoles to N-tert-butanesulfinyl imines resulting in the selective formation of chiral α-branched amines is described. This method is also efficient for highly regioselective benzylic lithiation of o-methylanisoles, followed by diastereoselective addition to N-tert-butanesulfinyl imines.