RESUMEN
It was found that the appearance of respiratory diseases among workers was established to be associated with the impact of aerosols with the complex chemical composition, exceeding corresponding MAC. Among respiratory diseases in workers there were detected predominantly chronic non-obstructive bronchitis - 59.15%, and chronic obstructive pulmonary disease (COPD) - in 35.2% of cases. In the analysis of spirometric indices of examined patients the vast majority (76.3%) of them showed disturbances of the bronchial patency of mild to moderate degree of the pronouncement. As a result of the implementation offlexible bronchoscopy there was established the presence of a diffuse lesion of bronchi with a predominance of subatrophic and atrophic processes in the mucosa. It was found that under the increase of the concentration of HF in the air of industrial premises the probability of bronchial obstruction and deterioration of the tracheobronchial patency in aluminum smelter workers was established to elevate.
Asunto(s)
Contaminantes Ocupacionales del Aire , Aluminio , Bronquitis Crónica , Industria Química , Enfermedades Profesionales , Enfermedad Pulmonar Obstructiva Crónica , Aerosoles/efectos adversos , Aerosoles/análisis , Aerosoles/química , Contaminantes Ocupacionales del Aire/análisis , Contaminantes Ocupacionales del Aire/toxicidad , Aluminio/análisis , Aluminio/química , Bronquitis Crónica/epidemiología , Bronquitis Crónica/etiología , Bronquitis Crónica/prevención & control , Industria Química/métodos , Industria Química/normas , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/epidemiología , Enfermedades Profesionales/etiología , Enfermedades Profesionales/prevención & control , Exposición Profesional/efectos adversos , Exposición Profesional/análisis , Exposición Profesional/prevención & control , Enfermedad Pulmonar Obstructiva Crónica/epidemiología , Enfermedad Pulmonar Obstructiva Crónica/etiología , Enfermedad Pulmonar Obstructiva Crónica/prevención & control , Siberia/epidemiología , TiempoRESUMEN
The article contains diagnostic error analysis of 439 patients with giant-cell tumor (176), bone cyst (158) and osteosarcoma (105) aged 4-75 for theperiod of 1990-2015. Morphological investigation of surgical material taken from the pathological focus sowed that diagnostic errors in clinical and X-ray examinations comprised up to 40.6% in giant -cell cases, 37.2% in bone cyst cases and 34.2% (p<0.05) in osteosarcoma cases.
Asunto(s)
Quistes Óseos , Neoplasias Óseas , Errores Diagnósticos , Tumor Óseo de Células Gigantes , Osteosarcoma , Adolescente , Adulto , Anciano , Quistes Óseos/diagnóstico por imagen , Quistes Óseos/patología , Neoplasias Óseas/diagnóstico , Neoplasias Óseas/patología , Niño , Preescolar , Femenino , Tumor Óseo de Células Gigantes/diagnóstico por imagen , Tumor Óseo de Células Gigantes/patología , Humanos , Masculino , Persona de Mediana Edad , Osteosarcoma/diagnóstico por imagen , Osteosarcoma/patologíaRESUMEN
The results of morphological research of stomach's mucouse membrane in children with functional dyspepsia are presented in the article. Microscopic changes were found in all examined children regardless of endoscopic state of the gastric and duodenum mucosa. Microscopic picture of the epithelium damage and regeneration was revealed; in more complicated cases, under the decline of regeneration potential features of interstitial inflammation appear. Actuality of morphological research in differential diagnostic of functional dyspepsia and chronic gastritis in children has been shown.
Asunto(s)
Duodeno/patología , Dispepsia/patología , Mucosa Gástrica/patología , Gastritis/patología , Mucosa Intestinal/patología , Estómago/patología , Adolescente , Niño , Enfermedad Crónica , Duodenoscopía , Dispepsia/diagnóstico , Femenino , Gastritis/diagnóstico , Gastroscopía , Histocitoquímica , Humanos , MasculinoRESUMEN
The article presents the current views and controversial issues problems comorbidity upper gastrointestinal tract in children and adolescents (gastroesophageal reflux disease and gastroduodenal diseases). Analyzed their own long-term observations, depending on the type of disease, severity of motor disorders, endoscopic and morphological picture, infection Helicobacter pylori. The possible options for the formation of gastroesophageal reflux disease in children and adolescents with gastroduodenal diseases.
Asunto(s)
Reflujo Gastroesofágico/patología , Infecciones por Helicobacter/patología , Úlcera Péptica/patología , Adolescente , Niño , Esófago/patología , Reflujo Gastroesofágico/complicaciones , Reflujo Gastroesofágico/diagnóstico , Reflujo Gastroesofágico/fisiopatología , Motilidad Gastrointestinal , Infecciones por Helicobacter/complicaciones , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/fisiopatología , Helicobacter pylori/crecimiento & desarrollo , Helicobacter pylori/patogenicidad , Humanos , Intestinos/patología , Úlcera Péptica/complicaciones , Úlcera Péptica/diagnóstico , Úlcera Péptica/fisiopatología , Estómago/patologíaRESUMEN
The article presents the operational characteristics of serological methods (neopterin, tumor necrosis factor-alpha, interleukin-6, molecules of adhesion of vascular endothelium, molecules of inter-cellular molecules of adhesion) of differential diagnostic of benign and malignant neoplasms of skeletal system. The differentiation of neoplasms occurs in a most successful way under analysis of complex of serological indicators.
Asunto(s)
Biomarcadores de Tumor/sangre , Neoplasias Óseas/diagnóstico , Neoplasias Óseas/sangre , Interpretación Estadística de Datos , Diagnóstico Diferencial , Humanos , Molécula 1 de Adhesión Intercelular/sangre , Interleucina-6/sangre , Neopterin/sangre , Factor de Necrosis Tumoral alfa/sangre , Molécula 1 de Adhesión Celular Vascular/sangreRESUMEN
The interface between LaAlO(3) and SrTiO(3) hosts a two-dimensional electron system of itinerant carriers, although both oxides are band insulators. Interface ferromagnetism coexisting with superconductivity has been found and attributed to local moments. Experimentally, it has been established that Ti 3d electrons are confined to the interface. Using soft x-ray angle-resolved resonant photoelectron spectroscopy we have directly mapped the interface states in k space. Our data demonstrate a charge dichotomy. A mobile fraction contributes to Fermi surface sheets, whereas a localized portion at higher binding energies is tentatively attributed to electrons trapped by O vacancies in the SrTiO(3). While photovoltage effects in the polar LaAlO(3) layers cannot be excluded, the apparent absence of surface-related Fermi surface sheets could also be fully reconciled in a recently proposed electronic reconstruction picture where the built-in potential in the LaAlO(3) is compensated by surface O vacancies serving also as a charge reservoir.
Asunto(s)
Enfermedades Óseas/diagnóstico , Desbridamiento/métodos , Equinococosis/diagnóstico , Tibia/parasitología , Animales , Enfermedades Óseas/parasitología , Enfermedades Óseas/cirugía , Diagnóstico Diferencial , Equinococosis/parasitología , Equinococosis/cirugía , Echinococcus granulosus/aislamiento & purificación , Femenino , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Radiografía , Recurrencia , Reoperación , Tibia/diagnóstico por imagen , Tibia/cirugíaRESUMEN
Morphofunctional characteristics of industrial microorganisms belonging to different genera, species, and strains were investigated after 15 to 20 years of storage in liquid nitrogen. The taxonomic position of microorganisms, the cell physiological state prior to storage, and the cryoconservation regime were found to affect microbial cryoresistance. Protective media, density of cell suspensions, freezing rate, and heating temperature are the parameters important for development of efficient technologies for cryoconservation of industrial microorganisms at -196 degrees C.
Asunto(s)
Bacterias/crecimiento & desarrollo , Bacteriófagos/crecimiento & desarrollo , Criopreservación , Microbiología Industrial , Bacterias/citología , Bacteriófagos/ultraestructura , Recuento de Colonia Microbiana , Nitrógeno/química , Factores de TiempoRESUMEN
Sets of primers for the species-specific detection of P. mirabilis and P. vulgaris by the polymerase chain reaction (PCR) were developed. As targets for these primers beta-lactamase and 16S rRNA gene fragments were chosen on the basis of the multiple leveling of the sequences of the DNA of all known P. mirabilis and P. vulgaris isolates. For differential detection oligonucleotides were selected in such a way that primers, specific for P. vulgaris, contained the non-paired nucleotide for P. mirabilis isolate at the 3'-end, and all other nucleotides were complementary to the beta-lactamase gene fragment. Primers, specific for gene 16S rRNA of P. mirabilis, contained the non-paired nucleotide for P. vulgaris isolates at the 3'-end. Standard PCR was carried out for 6 P. mirabilis and P. vulgaris strains. The use of PCR species-specific primers to P. vulgaris DNA made it possible to amplify the DNA fragment of the expected length only for P. vulgaris isolates, while the result of PCR for P. mirabilis was negative. PCR with primers specific to P. mirabilis permitted the detection of amplicon sized 101 nucleotides pairs only for P. mirabilis strains. These primers were optimized so as to use them in the specific differentiation of closely related P. mirabilis and P. vulgaris species by multiplex PCR. Genus-specific primers permitted the detection of bacterial gyrB gene of the genus Proteus were developed also.
Asunto(s)
Reacción en Cadena de la Polimerasa/métodos , Proteus mirabilis/genética , Proteus vulgaris/genética , Técnicas Bacteriológicas , Secuencia de Bases , Girasa de ADN/genética , Cartilla de ADN , ADN Bacteriano/genética , Datos de Secuencia Molecular , ARN Bacteriano/genética , ARN Ribosómico 16S/genética , Alineación de Secuencia , Especificidad de la Especie , beta-Lactamasas/genéticaRESUMEN
We analyze critical behavior associated with the loss of bistability for an atomistic model for CO oxidation on surfaces in the limit of infinite diffusion of CO. The model includes infinite nearest-neighbor repulsions between adsorbed immobile O. We use a "hybrid" treatment incorporating a lattice-gas description of the O adlayer, but tracking just the number of adsorbed CO (which are randomly distributed on non-O sites). The critical exponents obtained from a finite-size-scaling analysis on LxL site surfaces with periodic boundary conditions show that the "hybrid" reaction model belongs to the mean-field universality class, despite strong spatial correlations in the O adlayer. We also quantify finite-size effects in the global bifurcation diagram, revealing a significant shift of the bistable region with decreasing system size. Our study elucidates fluctuation effects observed in experiments of CO oxidation on the nanoscale facets of metal-field emitter tips.
RESUMEN
We present lattice-gas modeling of the steady-state behavior in CO oxidation on the facets of nanoscale metal clusters, with coupling via interfacet CO diffusion. The model incorporates the key aspects of the reaction process, such as rapid CO mobility within each facet and strong nearest-neighbor repulsion between adsorbed O. The former justifies our use of a "hybrid" simulation approach treating the CO coverage as a mean-field parameter. For an isolated facet, there is one bistable region where the system can exist in either a reactive state (with high oxygen coverage) or a (nearly CO-poisoned) inactive state. Diffusion between two facets is shown to induce complex multistability in the steady states of the system. The bifurcation diagram exhibits two regions with bistabilities due to the difference between adsorption properties of the facets. We explore the role of enhanced fluctuations in the proximity of a cusp bifurcation point associated with one facet in producing transitions between stable states on that facet, as well as their influence on fluctuations on the other facet. The results are expected to shed more light on the reaction kinetics for supported catalysts.
RESUMEN
Phagocytic activity of peritoneal macrophages in cases of separate and combined injections of killed bacterial vaccines and prospidin has been studied in the work. As a result of researches conducted, it has been found out that the injection of vaccines together with prospidin makes it possible to reduce an inhibiting effect of prospidin on phagocytic activity of monocyte-macrophagal cells; first of all it concerns their digestive activity. Thus, the immunodepressing effect of antiblastome drugs may be reduced with the help of injection of killed bacterial vaccines which stimulate nonspecific factors of organism protection, including antineoplastic ones.
Asunto(s)
Vacunas Bacterianas/administración & dosificación , Escherichia coli/inmunología , Macrófagos Peritoneales/inmunología , Prospidio/farmacología , Pseudomonas aeruginosa/inmunología , Animales , Vacunas Bacterianas/inmunología , Interacciones Farmacológicas , Inyecciones Intramusculares , Inyecciones Subcutáneas , Ratones , Ratones Endogámicos C57BL , Fagocitosis/efectos de los fármacos , Prospidio/administración & dosificaciónRESUMEN
The possibility of monooxygenase enzymes biomimetic construction models with the use of polynuclear manganese complexes was shown. It was demonstration that benzene is oxidized by polynuclear manganese complex [Mn12O12(CH3CO2)16(H2O)4] in acetonitrile solution at room temperature and atmospheric pressure yielding phenol with the selectivity more than 80%. It was determined that the addition of air oxygen as the reoxidizer to the reaction mixture didn't transfer the reaction into the catalytic mode.
Asunto(s)
Benceno/química , Compuestos de Manganeso/química , Catálisis , Imitación Molecular , Oxidación-Reducción , TemperaturaAsunto(s)
Enfermedades Óseas/cirugía , Equinococosis/cirugía , Tibia/cirugía , Cúbito/cirugía , Adulto , Enfermedades Óseas/diagnóstico por imagen , Equinococosis/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Radiografía , Tibia/diagnóstico por imagen , Cúbito/diagnóstico por imagenRESUMEN
180 patients with scoliosis (aged 12-29 years) were subjected to the correction of deformation by means of the Harringtone type distractors and spondylodesis with utilization of osseous transplants. In 24 of them (13,3%) the distractor has been broken in different terms after the operation. The danger of the break increases with the age of the patients and abruptly increases in case of scoliosis of the V degree (in excess of 90 degrees) and in case of necessity to bend the distractor to correct the kyphoscoliosis. The distractor break is associated not with the material structure but with the rod design.