Earth's atmosphere, whose ionization stability plays a fundamental role for the evolution and endurance of life, is exposed to the effect of cosmic explosions producing high energy Gamma-ray-bursts. Being able to abruptly increase the atmospheric ionization, they might deplete stratospheric ozone on a global scale. During the last decades, an average of more than one Gamma-ray-burst per day were recorded. Nevertheless, measurable effects on the ionosphere were rarely observed, in any case on its bottom-side (from about 60 km up to about 350 km of altitude). Here, we report evidence of an intense top-side (about 500 km) ionospheric perturbation induced by significant sudden ionospheric disturbance, and a large variation of the ionospheric electric field at 500 km, which are both correlated with the October 9, 2022 Gamma-ray-burst (GRB221009A).
OBJECTIVE: Early synchrony alterations have been observed through electrophysiological techniques in Mild Cognitive Impairment (MCI), which is considered the intermediate phase between healthy aging (HC) and Alzheimer's disease (AD). However, the documented direction (hyper/hypo-synchronization), regions and frequency bands affected are inconsistent. This meta-analysis intended to elucidate existing evidence linked to potential neurophysiological biomarkers of AD. METHODS: We conducted a random-effects meta-analysis that entailed the unbiased inclusion of Non-statistically Significant Unreported Effect Sizes ("MetaNSUE") of electroencephalogram (EEG) and magnetoencephalogram (MEG) studies investigating functional connectivity changes at rest along the healthy-pathological aging continuum, searched through PubMed, Scopus, Web of Science and PsycINFO databases until June 2023. RESULTS: Of the 3852 articles extracted, we analyzed 12 papers, and we found an alpha synchrony decrease in MCI compared to HC, specifically between temporal-parietal (d = -0.26) and frontal-parietal areas (d = -0.25). CONCLUSIONS: Alterations of alpha synchrony are present even at MCI stage. SIGNIFICANCE: Synchrony measures may be promising for the detection of the first hallmarks of connectivity alterations, even at the prodromal stages of the AD, before clinical symptoms occur.
Alzheimer Disease , Cognitive Dysfunction , Humans , Cognitive Dysfunction/diagnostic imaging , Electroencephalography/methods , Magnetoencephalography , Brain/diagnostic imaging
The Burridge-Knopoff model implements an earthquake fault as a mechanical block-spring chain. While numerical studies of the model are abundant, experimental investigations are limited to a two-blocks, analog electronic implementation that was proposed by drawing an analogy between mechanical and electrical quantities. Although elegant, this approach is not versatile, mostly because of its heavy reliance on inductors. Here, we propose an alternative, inductorless implementation of the same system. The experimental characterization of the proposed circuit shows very good agreement with theoretical predictions. Besides periodic oscillations, the circuit exhibits a chaotic regime: the corresponding markers of chaoticity, namely, the correlation dimension and the maximum Lyapunov exponent, were experimentally assessed to be consistent with those provided by numerical simulations. The improved versatility and scalability of the circuit is expected to allow for experimental implementations of the Burridge-Knopoff model with a large number of blocks. In addition, the circuit can be used as the basic element of scalable platforms to investigate the dynamics of networks of oscillators and related phenomena.
In the last decade permutation entropy (PE) has become a popular tool to analyze the degree of randomness within a time series. In typical applications, changes in the dynamics of a source are inferred by observing changes of PE computed on different time series generated by that source. However, most works neglect the crucial question related to the statistical significance of these changes. The main reason probably lies in the difficulty of assessing, out of a single time series, not only the PE value, but also its uncertainty. In this paper we propose a method to overcome this issue by using generation of surrogate time series. The analysis conducted on both synthetic and experimental time series shows the reliability of the approach, which can be promptly implemented by means of widely available numerical tools. The method is computationally affordable for a broad range of users.
The neural activity of human brain changes in healthy individuals during aging. The most frequent variation in patterns of neural activity are a shift from posterior to anterior areas and a reduced asymmetry between hemispheres. These patterns are typically observed during task execution and by using functional magnetic resonance imaging data. In the present study we investigated whether analogous effects can also be detected during rest and by means of source-space time series reconstructed from electroencephalographic recordings. By analyzing oscillatory power distribution across the brain we indeed found a shift from posterior to anterior areas in older adults. We additionally examined this shift by evaluating connectivity and its changes with age. The findings indicated that inter-area connections among frontal, parietal and temporal areas were strengthened in older individuals. A more complex pattern was shown in intra-area connections, where age-related activity was enhanced in parietal and temporal areas, and reduced in frontal areas. Finally, the resulting network exhibits a loss of modularity with age. Overall, the results extend to resting-state condition the evidence of an age-related shift of brain activity from posterior to anterior areas, thus suggesting that this shift is a general feature of the aging brain rather than being task-specific. In addition, the connectivity results provide new information on the reorganization of resting-state brain activity in aging.
Healthy Aging , Aged , Brain/diagnostic imaging , Brain Mapping , Electroencephalography , Humans , Magnetic Resonance Imaging , Neural Pathways , Rest
BACKGROUND: Motivation is a core component of diabetes self-management because it allows adults with diabetes mellitus (DM) to adhere to clinical recommendations. In this context, virtual coaches (VCs) have assumed a central role in supporting and treating common barriers related to adherence. However, most of them are mainly focused on medical and physical purposes, such as the monitoring of blood glucose levels or following a healthy diet. OBJECTIVE: This proof-of-concept study aims to evaluate the preliminary efficacy of a VC intervention for psychosocial support before and after the intervention and at follow-up. The intent of this VC is to motivate adults with type 1 DM and type 2 DM to adopt and cultivate healthy coping strategies to reduce symptoms of depression, anxiety, perceived stress, and diabetes-related emotional distress, while also improving their well-being. METHODS: A total of 13 Italian adults with DM (18-51 years) interacted with a VC, called Motibot (motivational bot) using the Telegram messaging app. The interaction covered 12 sessions, each lasting 10 to 20 minutes, during which the user could dialogue with the VC by inputting text or tapping an option on their smartphone screen. Motibot is developed within the transtheoretical model of change to deliver the most appropriate psychoeducational intervention based on the user's motivation to change. RESULTS: Results showed that over the 12 sessions, there were no significant changes before and after the intervention and at follow-up regarding psychosocial factors. However, most users showed a downward trend over the 3 time periods in depression and anxiety symptoms, thereby presenting good psychological well-being and no diabetes-related emotional distress. In addition, users felt motivated, involved, encouraged, emotionally understood, and stimulated by Motibot during the interaction. Indeed, the analyses of semistructured interviews, using a text mining approach, showed that most users reported a perceived reduction in anxiety, depression, and/or stress symptoms. Moreover, users indicated the usefulness of Motibot in supporting and motivating them to find a mindful moment for themselves and to reflect on their own emotions. CONCLUSIONS: Motibot was well accepted by users, particularly because of the inclusion of mindfulness practices, which motivated them to adopt healthy coping skills. To this extent, Motibot provided psychosocial support for adults with DM, particularly for those with mild and moderate symptoms, whereas those with severe symptoms may benefit more from face-to-face psychotherapy.
The statistical analysis of data stemming from dynamical systems, including, but not limited to, time series, routinely relies on the estimation of information theoretical quantities, most notably Shannon entropy. To this purpose, possibly the most widespread tool is provided by the so-called plug-in estimator, whose statistical properties in terms of bias and variance were investigated since the first decade after the publication of Shannon's seminal works. In the case of an underlying multinomial distribution, while the bias can be evaluated by knowing support and data set size, variance is far more elusive. The aim of the present work is to investigate, in the multinomial case, the statistical properties of an estimator of a parameter that describes the variance of the plug-in estimator of Shannon entropy. We then exactly determine the probability distributions that maximize that parameter. The results presented here allow one to set upper limits to the uncertainty of entropy assessments under the hypothesis of memoryless underlying stochastic processes.
The task of identifying and characterizing network structures out of experimentally observed time series is tackled by implementing different solutions, ranging from entropy-based techniques to the evaluation of the significance of observed correlation estimators. Among the metrics that belong to the first class, mutual information is of major importance due to the relative simplicity of implementation and its relying on the crucial concept of entropy. With regard to the second class, a method that allows us to assess the connectivity strength of a link in terms of a time scale of its observability via the significance estimate of measured cross correlation was recently shown to provide a reliable tool to study network structures. In this paper, we investigate the relationship between this last metric and mutual information by simultaneously assessing both metrics on large sets of data extracted from three experimental contexts, human brain magnetoencephalography, human brain electroencephalography, and surface wind measurements carried out on a small regional scale, as well as on simulated coupled, auto-regressive processes. We show that the relationship is well described by a power law and provide a theoretical explanation based on a simple noise and signal model. Besides further upholding the reliability of cross-correlation time scale of observability, the results show that the combined use of this metric and mutual information can be used as a valuable tool to identify and characterize connectivity links in a wide range of experimental contexts.
Electroencephalography , Magnetoencephalography , Brain , Entropy , Humans , Reproducibility of Results
The amount of information exchanged per unit of time between two dynamic processes is an important concept for the analysis of complex systems. Theoretical formulations and data-efficient estimators have been recently introduced for this quantity, known as the mutual information rate (MIR), allowing its continuous-time computation for event-based data sets measured as realizations of coupled point processes. This work presents the implementation of MIR for point process applications in Network Physiology and cardiovascular variability, which typically feature short and noisy experimental time series. We assess the bias of MIR estimated for uncoupled point processes in the frame of surrogate data, and we compensate it by introducing a corrected MIR (cMIR) measure designed to return zero values when the two processes do not exchange information. The method is first tested extensively in synthetic point processes including a physiologically-based model of the heartbeat dynamics and the blood pressure propagation times, where we show the ability of cMIR to compensate the negative bias of MIR and return statistically significant values even for weakly coupled processes. The method is then assessed in real point-process data measured from healthy subjects during different physiological conditions, showing that cMIR between heartbeat and pressure propagation times increases significantly during postural stress, though not during mental stress. These results document that cMIR reflects physiological mechanisms of cardiovascular variability related to the joint neural autonomic modulation of heart rate and arterial compliance.
The detection of an underlying chaotic behavior in experimental recordings is a longstanding issue in the field of nonlinear time series analysis. Conventional approaches require the assessment of a suitable dimension and lag pair to embed a given input sequence and, thereupon, the estimation of dynamical invariants to characterize the underlying source. In this work, we propose an alternative approach to the problem of identifying chaos, which is built upon an improved method for optimal embedding. The core of the new approach is the analysis of an input sequence on a lattice of embedding pairs whose results provide, if any, evidence of a finite-dimensional, chaotic source generating the sequence and, if such evidence is present, yield a set of equivalently suitable embedding pairs to embed the sequence. The application of this approach to two experimental case studies, namely, an electronic circuit and magnetoencephalographic recordings of the human brain, highlights how it can make up a powerful tool to detect chaos in complex systems.
Many studies in nonlinear science heavily rely on surrogate-based hypothesis testing to provide significance estimations of analysis results. Among the complex data produced by nonlinear systems, spike trains are a class of sequences requiring algorithms for surrogate generation that are typically more sophisticated and computationally demanding than methods developed for continuous signals. Although algorithms to specifically generate surrogate spike trains exist, the availability of open-source, portable implementations is still incomplete. In this paper, we introduce the SpiSeMe (Spike Sequence Mime) software package that implements four algorithms for the generation of surrogate data out of spike trains and more generally out of any sequence of discrete events. The purpose of the package is to provide a unified and portable toolbox to carry out surrogate generation on point-process data. Code is provided in three languages, namely, C++, Matlab, and Python, thus allowing straightforward integration of package functions into most analysis pipelines.
Language , Software , Action Potentials , Algorithms , Computer Simulation , Humans , Models, Neurological
The divergence rate method, which is used to determine the maximum Lyapunov exponent out of time series, is based on the evaluation of the time-dependent divergence exponent. For chaotic systems and in the small time regime, this exponent grows linearly in time. The asymptotic regime is instead characterized by a time-independent behavior due to the system eventually losing its memory of the starting conditions. The amplitude of this "plateau"-like divergence exponent depends both on the choice of the embedding dimension and lag and on the maximum distance of nearby starting trajectories in a way that is characteristic of the underlying dynamical system. In this paper, upon introducing the basic mathematical tools, we address the plateau evaluation for two classes of time series, those generated by a white noise source and those generated by a finite-dimensional chaotic system. The different behavior provides a novel tool to distinguish purely stochastic sources from deterministic ones, as well as to provide a precise estimate of the correlation dimension in the latter case. The method is also sensitive to correlated noise sources.
Physical connections between nodes in a complex network are constrained by limiting factors, such as the cost of establishing links and maintaining them, which can hinder network capability in terms of signal propagation speed and processing power. Trade-off mechanisms between cost constraints and performance requirements are reflected in the topology of a network and, ultimately, on the dependence of connectivity on geometric distance. This issue, though rarely addressed, is crucial in neuroscience, where physical links between brain regions are associated with a metabolic cost. In this work we investigate brain connectivity-estimated by means of a recently developed method that evaluates time scales of cross-correlation observability-and its dependence on geometric distance by analyzing resting state magnetoencephalographic recordings collected from a large set of healthy subjects. We identify three regimes of distance each showing a specific behavior of connectivity. This identification makes up a new tool to study the mechanisms underlying network formation and sustainment, with possible applications to the investigation of neuroscientific issues, such as aging and neurodegenerative diseases.
In any network, the dependence of connectivity on physical distance between nodes is a direct consequence of trade-off mechanisms between costs of establishing and sustaining links, processing rates, propagation speed of signals between nodes. Despite its universality, there are still few studies addressing this issue. Here we apply a recently-developed method to infer links between nodes, and possibly subnetwork structures, to determine connectivity strength as a function of physical distance between nodes. The model system we investigate is brain activity reconstructed on the cortex out of magnetoencephalography recordings sampled on a set of healthy subjects in resting state. We found that the dependence of the time scale of observability of a link on its geometric length follows a power-law characterized by an exponent whose extent is inversely proportional to connectivity. Our method provides a new tool to highlight and investigate networks in neuroscience.
Brain Mapping/methods , Brain/physiology , Connectome , Image Processing, Computer-Assisted/methods , Magnetoencephalography/methods , Neural Pathways/physiology , Adult , Female , Humans , Male , Models, Biological , Rest/physiology , Young Adult
The study of many dynamical systems relies on the analysis of experimentally-recorded sequences of events for which information is encoded in the sequence of interevent intervals. A correct interpretation of the results of the application of analytical techniques to these sequences requires the assessment of statistical significance. In most cases, the corresponding null-hypothesis distribution is unknown, thus forbidding an evaluation of the significance. An alternative solution, which is efficient in the case of continuous signals, is provided by the generation of surrogate data that share statistical and spectral properties with the original dataset. However, in the case of event sequences, the available algorithms for the generation of surrogate data can become cumbersome and computationally demanding. In this work, we present a new method for the generation of surrogate event sequences that relies on the joint distribution of successive interevent intervals. Our method, which was tested on both synthetic and experimental sequences, performs equally well or even better than conventional methods in terms of interevent interval distribution and autocorrelation while abating the computational time by at least one order of magnitude.
