RESUMEN
The aim of the study was to estimate the efficacy of liniment cycloferon included in combined therapy of herpetic infection in 30 patients with psoriasis divided into 2 groups. Combined treatment of patients with recurrent herpetic infection promoted elimination of general infection syndrome, shortened duration of eruption and local inflammation, accelerated epithelization of herpetic erosion, and decreased the frequency of relapses during the follow-up.
Asunto(s)
Acridinas , Infecciones por Herpesviridae , Herpesvirus Humano 1 , Psoriasis , Repitelización/efectos de los fármacos , Acridinas/administración & dosificación , Acridinas/efectos adversos , Aciclovir/uso terapéutico , Adulto , Antiinfecciosos Locales , Antivirales/uso terapéutico , Comorbilidad , Quimioterapia Combinada , Femenino , Infecciones por Herpesviridae/tratamiento farmacológico , Infecciones por Herpesviridae/epidemiología , Infecciones por Herpesviridae/fisiopatología , Infecciones por Herpesviridae/virología , Herpesvirus Humano 1/efectos de los fármacos , Herpesvirus Humano 1/aislamiento & purificación , Humanos , Inmunomodulación , Inductores de Interferón/administración & dosificación , Inductores de Interferón/efectos adversos , Linimentos , Masculino , Psoriasis/epidemiología , Psoriasis/fisiopatología , Recurrencia , Resultado del TratamientoRESUMEN
The efficiency of cycloferon liniment in combined treatment of herpetic infection in patients with latent form of HIV infection has been assess by observations of 40 patients divided into two groups. In the first group, the standard treatment was supplemented with the application of cycloferon liniment twice a day during 7 days; in the second group, the therapy was conducted according to standard recommendations. It was established that the application of cycloferon liniment in combination with standard therapy in patients with relapse of herpetic infection against the background of HIV infection ensures faster disappearance of general infectious syndrome, decreases the period of eruptions and the duration of local inflammations, and accelerates the epithelialization of erosions.
Asunto(s)
Acridinas/uso terapéutico , Infecciones por VIH/tratamiento farmacológico , VIH/efectos de los fármacos , Herpes Simple/tratamiento farmacológico , Herpesviridae/efectos de los fármacos , Factores Inmunológicos/uso terapéutico , Acridinas/farmacología , Administración Tópica , Adulto , Coinfección , Quimioterapia Combinada , Femenino , VIH/fisiología , Infecciones por VIH/inmunología , Infecciones por VIH/virología , Herpes Simple/inmunología , Herpes Simple/virología , Herpesviridae/inmunología , Humanos , Factores Inmunológicos/farmacología , Linimentos , Masculino , Latencia del VirusRESUMEN
Therapeutic potential of cyclopheron was evaluated as exemplified by the treatment of patients with chronic brucellosis. Positive clinical dynamics during combined treatment including cyclopheron is apparent as reduced duration of intoxication and inflammation, improved quality of life, decreased frequency of exacerbation of the infectious process and development of intercurrent diseases. These effects are shown to be due to immunomodulating activity of cyclopheron and suppression of lipid peroxidation. Also, the drug increases activity of antioxidants, decreases the levels of proinflammatory (and to a lesser degree of anti-inflammatory) cytokines.