The aim of the study was to estimate the efficacy of liniment cycloferon included in combined therapy of herpetic infection in 30 patients with psoriasis divided into 2 groups. Combined treatment of patients with recurrent herpetic infection promoted elimination of general infection syndrome, shortened duration of eruption and local inflammation, accelerated epithelization of herpetic erosion, and decreased the frequency of relapses during the follow-up.
Acridines , Herpesviridae Infections , Herpesvirus 1, Human , Psoriasis , Re-Epithelialization/drug effects , Acridines/administration & dosage , Acridines/adverse effects , Acyclovir/therapeutic use , Adult , Anti-Infective Agents, Local , Antiviral Agents/therapeutic use , Comorbidity , Drug Therapy, Combination , Female , Herpesviridae Infections/drug therapy , Herpesviridae Infections/epidemiology , Herpesviridae Infections/physiopathology , Herpesviridae Infections/virology , Herpesvirus 1, Human/drug effects , Herpesvirus 1, Human/isolation & purification , Humans , Immunomodulation , Interferon Inducers/administration & dosage , Interferon Inducers/adverse effects , Liniments , Male , Psoriasis/epidemiology , Psoriasis/physiopathology , Recurrence , Treatment Outcome
The efficiency of cycloferon liniment in combined treatment of herpetic infection in patients with latent form of HIV infection has been assess by observations of 40 patients divided into two groups. In the first group, the standard treatment was supplemented with the application of cycloferon liniment twice a day during 7 days; in the second group, the therapy was conducted according to standard recommendations. It was established that the application of cycloferon liniment in combination with standard therapy in patients with relapse of herpetic infection against the background of HIV infection ensures faster disappearance of general infectious syndrome, decreases the period of eruptions and the duration of local inflammations, and accelerates the epithelialization of erosions.
Acridines/therapeutic use , HIV Infections/drug therapy , HIV/drug effects , Herpes Simplex/drug therapy , Herpesviridae/drug effects , Immunologic Factors/therapeutic use , Acridines/pharmacology , Administration, Topical , Adult , Coinfection , Drug Therapy, Combination , Female , HIV/physiology , HIV Infections/immunology , HIV Infections/virology , Herpes Simplex/immunology , Herpes Simplex/virology , Herpesviridae/immunology , Humans , Immunologic Factors/pharmacology , Liniments , Male , Virus Latency
Therapeutic potential of cyclopheron was evaluated as exemplified by the treatment of patients with chronic brucellosis. Positive clinical dynamics during combined treatment including cyclopheron is apparent as reduced duration of intoxication and inflammation, improved quality of life, decreased frequency of exacerbation of the infectious process and development of intercurrent diseases. These effects are shown to be due to immunomodulating activity of cyclopheron and suppression of lipid peroxidation. Also, the drug increases activity of antioxidants, decreases the levels of proinflammatory (and to a lesser degree of anti-inflammatory) cytokines.
Acridines/therapeutic use , Brucellosis/drug therapy , Interferon Inducers/therapeutic use , Adult , Brucellosis/physiopathology , Humans , Middle Aged
