1.
Rev Prat
; 58(12): 1387-90, 2008 Jun 30.
Artículo
en Francés
| MEDLINE
| ID: mdl-18714662
Asunto(s)
Medicina en las Artes , Historia del Siglo XIX , Historia del Siglo XX , Hospitales/historia , Humanos , Paris , Política
2.
FEMS Immunol Med Microbiol
; 32(2): 141-7, 2002 Jan 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11821236
RESUMEN
Vesicles consisting of pure trehalose dicorynomycolate (TDCM), the corynebacterial analog of the most studied mycobacterial glycolipid 'cord factor', were isolated from Corynebacterium glutamicum cells by mild detergent treatment; these induced in vivo a macrophage priming similar to that obtained with mycobacterial-derived trehalose dimycolate. In vitro, both TDCM and bacterial lipopolysaccharide (LPS) induced in macrophages the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha), endotoxin tolerance, and were primed for an enhanced secondary NO response to LPS. Interferon-gamma pretreatment did not influence the LPS-induced TNF-alpha response, but considerably increased the TDCM-induced response.