Laboratory features in acute paediatric poisoning with liquid laundry detergent capsules: a seven-year retrospective study in Romania.

INTRODUCTION: The epidemiological and clinical characteristics of acute poisoning with liquid laundry detergent capsules have been comprehensively reported. However, studies of laboratory test results in these exposures are uncommon. This study analyzed the impact of the ingestion of liquid laundry detergent capsules on admission laboratory tests in paediatric patients. METHODS: This retrospective study was conducted in the clinical toxicology unit of a paediatric poison centre between 2015 and 2021. Paediatric patients (less than 18 years of age) who ingested liquid laundry detergent capsules were included. The relationship between the European Association of Poisons Centers and Clinical Toxicologists/European Commission/International Programme on Chemical Safety Poisoning Severity Score and admission laboratory test results was assessed using Fisher's exact test or analysis of variance. RESULTS: A total of 156 patients were included in the study. A considerable proportion of patients presented with leucocytosis, acidosis, hyperlactataemia or base deficit. The median values of white blood cell count (P = 0.042), pH (P = 0.022), and base excess (P = 0.013) were significantly different among the Poisoning Severity Score groups. Hyperlactataemia was strongly associated with the Poisoning Severity Score (P = 0.003). DISCUSSION: Leucocytosis is a non-specific marker of severity following ingestion of liquid laundry detergent capsules. The incidence of metabolic acidosis and hyperlactataemia was higher in this study than in previous reports, but these metabolic features were not related to the severity of exposure. The exact mechanisms of toxicity are not yet known, but the high concentration of non-ionic and anionic surfactants, as well as propylene glycol and ethanol, in the capsule are likely contributing factors. CONCLUSIONS: Pediatric patients who ingest liquid laundry detergent capsules may develop leucocytosis, metabolic acidosis, hyperlactataemia, and a base deficit.

Maladaptive Personality Traits in a Group of Patients with Substance Use Disorder and ADHD.

Background and Objectives: the comorbidity of personality disorders in patients who use psychoactive substances is common in psychiatric practice. The epidemiology of disharmonious personality traits in patients with ADHD and addictions in adulthood is still insufficiently researched. The study investigated the typology of personality traits in a group of adult patients consuming psychoactive substances, in whom symptoms of ADHD were identified. Materials and Methods: the study evaluates a group of 104 patients with chronic psychoactive substances abuse, in whom symptoms of ADHD were identified in early adulthood, in terms of comorbid personality traits. Results: statistically significant data have been obtained regarding the presence of clinical traits characteristic for cluster B personality disorders, the patients presenting lower levels of self-control, self-image instability, difficulties in the areas of social relationships and own identity integration. Conclusions: ADHD symptomatology precedes the clinical traits of personality disorders in patients with addictions, negatively influencing chronic evolution and quality of life.

The accuracy of alveolar crest dimensions measurement for dental implants. In vitro study.

OBJECTIVES: The aim of this study was to evaluate the accuracy of radiological examination methods in quantitative preimplantar bone assessment. MATERIAL AND METHOD: The study was carried out on a dry cranium, totally edentate. There have been radiological appreciated the height of the alveolar process and its width, both to the maxilla and the mandible. Also, it has been established the distance between the free edge of the alveolar crest and the superior edge of the mandibular canal. The values radiological measured have then been compared with those obtained through direct measurement of these dimensions on the cranium. RESULTS: The results were performed in tables and diagrams. The greatest deviation from the real values was at the panoramic radiography, while the computer tomography was the most accurate examination among the radiological techniques used in this study. The panoramic radiography doesn't give information about the alveolar crest thickness, about it's declivity and the alveolar crest measurement generates significant errors. Linear tomography implies a difficult technique, but it has the advantage of a low irradiation,a wider accessibility and a lower cost than the CT. Computer tomography is the most accurate preimplantar evaluation technique but it has the disadvantage of a high patient radiation. CONCLUSIONS: The panoramic radiography represents an insufficient method for appreciating the preimplantar bone status. That's why it has to be supplemented with other radiological examinations, especially at the cases with alveolar crest atrophy, to avoid accidental penetration of adjacent structures.