Carboxymethylcellulose sodium-derived carbon aerogels for solar-driven water purification.

Recycling polluted water via different techniques has become one of the most feasible ways to solve the freshwater crisis. We describe a novel method to prepare reusable and efficient photothermal energy conversion materials for water purification. Using crosslinked xerogels as precursor, the porous and interconnected carboxymethylcellulose sodium-derived carbon aerogels (abbreviated as CCAs) with good hydrophilic performance and strong light absorption capability are firstly fabricated through pyrolysis. Photothermal measurement results show that CCA15 exhibit excellent solar steam generation rate of 2.31 kg m-2 h-1 with high light-to-vapor conversion efficiency of 95.9% under 1 sun illumination. In addition, the feasible application of CCA15 for efficient water purification under 1 sun irradiation using a homemade water treatment device has been demonstrated successfully. The as-prepared CCAs shown in here can be a continuable solution to mitigate the global freshwater crisis.

Research Progress on Hygroscopic Agents for Atmospheric Water Harvesting Systems.

Adsorptive atmospheric water harvesting systems (AWHs) represent an innovative approach to collecting freshwater resources from the atmosphere, with a hygroscopic agent at their core. This method has garnered significant attention due to its broad applicability, strong recycling capacity, and sustainability. It is being positioned as a key technology to address global freshwater scarcity. The core agent's hygroscopic properties play a crucial role in determining the performance of the AWHs. This article provides a comprehensive review of the latest advancements in hygroscopic agents, including their adsorption mechanisms and classifications. This study of hygroscopic agents analyzes the performance and characteristics of relevant porous material composite polymer composites and plant composites. It also evaluates the design and preparation of these materials. Aiming at the problems of low moisture adsorption and desorption difficulty of the hygroscopic agent, the factors affecting the water vapor adsorption performance and the method of enhancing the hygroscopic performance of the material are summarized and put forward. For the effect of hygroscopic agents on the volume of water catchment devices, the difference in density before and after hygroscopicity is proposed as part of the evaluation criteria. Moisture absorption per unit volume is added as a performance evaluation criterion to assess the effect of hygroscopic agents on the volume of water collection equipment. The article identifies areas that require further research and development for moisture absorbers, exploring their potential applications in other fields and anticipating the future development direction and opportunities of moisture-absorbing materials. The goal is to promote the early realization of adsorptive atmospheric water harvesting technology for large-scale industrial applications.

Microbial mechanism of biochar addition to reduce N2O emissions from soilless substrate systems.

The soilless peat-based substrate partially solves the global soil problem in greenhouse vegetable production. However, it still produces serious N2O emissions due to the application of nutrient solutions. The pyrolysis biochar is regarded as an effective measure to reduce soil N2O emissions. However, the effect and mechanism of biochar on N2O emissions from the soilless substrate remain unknown. Therefore, this study set up six treatments by adjusting the ratio of biochar addition of peat-based substrate: 0% (0BC), 2% (2BC), 4% (4BC), 6% (6BC), 8% (8BC) and 10% (10BC) (v/v). The results showed that compared to the control treatment, N2O emissions reduced by 81%, 71%, 51%, 61%, and 75% in the 2BC, 4BC, 6BC, 8BC and 10BC treatments, respectively. In addition, lettuce yield increased by 10% and 7% in the 2BC and 4BC treatments and decreased by 0.5%, 4% and 6% in the 6BC, 8BC and 10BC treatments, respectively. Combining stable isotope technology, qPCR analysis and high-throughput sequencing, five microbial pathways of N2O production, including bacterial and archaea nitrification (BN and AN), denitrification performed by fungi, denitrifier bacteria and nitrifier bacteria (FD, DD and ND), were roughly distinguished. In addition, the extent of N2O reduction was obtained by δ18O vs.δ15NSP map. For all treatments, overall, the DD process (over 50%) was the main process of N2O production and reduction, while ND and AN processes were almost negligible (less 5%). In detail, the decrease of N2O emissions was caused by decreasing the contribution of FD in the 6BC, 8BC and 10BC treatments and reducing the contribution of BN in the 0BC and 2BC treatments. In addition, biochar addition increased the extent of N2O reduction to N2. In summary, the 2% biochar addition presented the greatest extent of N2O reduction to N2 (83%) and the lowest N2O emissions as well as the highest lettuce yields and nitrogen utilization efficiency. Therefore, 2% biochar is deemed the most optimal addition to the peat-based substrate.

Nitrogen transformation and its microbial mechanism under co-composting of biogas slurry with garden waste.

Large amount of garden waste is consecutively produced in China every year. The composting with urea and microbial inoculum makes it possible to dispose garden waste in large quantities. However, composting accompanies with serious nitrogen loss and environmental problems. The biogas slurry contains considerable nitrogen nutrients and microorganisms, which theoretically could be used as alternative to urea and bacteria to reduce nitrogen loss, respectively. We set up three treatments of biogas slurry + garden waste (GB), biogas slurry + garden waste + urea (GBU), and biogas slurry + garden waste + urea + microbial inoculum (GBUM) to investigate the decomposition, nitrogen conversion and nitrogen loss in the co-composting process. The results showed that the high tempe-rature period of GB treatment was longer and more stable compared to that of GBU and GBUM treatments. The pH and EC value of GB treatment would benefit composting process and generated products with the highest germination index (GI) (221.8%). In addition, NH3 and N2O emission rates in the GB treatment were 2.59 mg·kg-1·d-1 and 3.65 µg·kg-1·d-1, respectively, being 99.0% and 50.0% lower than that in the GBU treatment and 99.4% and 40.7% lower than that in the GBUM treatment. The results of δ18O vs. δ15NSP dual isotopocule plots approach analysis showed that the GB and GBU treatments were dominated by denitrification, and that the contribution of denitrification was higher in the GB treatment. In contrast, the GBUM treatment was dominated by nitrification. The degree of N2O reduction in GB treatment (83.7%) was higher than the other two treatments. It was clear that GB treatment had the best maturity and lowest nitrogen loss in all treatments by enhancing the N2O reduction process during denitrification to reduce N2O emission. In conclusion, the biogas slurry and garden wastes could be directly co-composted without the limitation of C/N and microbial addition. The co-composting method could protect the environment and save resources leading to the recycling of waste in actual production.

Insights into production and consumption processes of nitrous oxide emitted from soilless culture systems by dual isotopocule plot and functional genes.

Soilless culture systems (SCS) play an increasing role in greenhouse vegetable production. In the SCS, soilless substrates serve as the major substitute for soil, supplying nutrients to plants but releasing greenhouse gases into the atmosphere. Remarkably, there is a serious problem of N2O emission due to excessive input of N fertilizer. However, the microbial processes of N2O production and consumption in soilless substrates have been rarely studied resulting in difficultly interpreting for its global warming potential. Therefore, these pathways from two classic soilless substrates under two irrigation patterns were investigated by stable isotope technology combined with qPCR analysis in present study. The results according to the dual isotopocule plot of δ15NSP vs. δ18O showed that the mean contribution of denitrification and the mean extent of N2O reduction of case i (Reduction-Mixing) were 26.2 and 81.2 % for the treatment of peat based substrate under drip irrigation (PD), 47.7 and 70.3 % for the treatment of coir substrate under drip irrigation (CD), 29.0 and 80.8 % for the treatment of peat based substrate under tidal irrigation (PT), and 50.8 and 47.4 % for the treatment of coir substrate under tidal irrigation (CT). These results were also further confirmed by the abundance of major functional genes including AOA amoA, nirK and nosZ. Altogether, N2O emission and its microbial processes are determined by substrate types instead of irrigation patterns. For detail, denitrification dominated in the peat based substrate and nitrification dominated in the coir substrate. Compared to the coir substrate, the peat based substrate had higher abundance of functional genes and stronger denitrification and thus generated more N2O. For the two soilless substrates, moreover, the microbiome replaced the mineral N content as the limiting factor for N2O emission. In the SCS, in summary, the two soilless substrates play an important role in tomato growth, but might suffer from inorganic nutrient surplus and microbial shortage. More importantly, the combined analysis of N2O isotopocule deltas and functional genes is a robust tool and provides reliable conclusions for clarifying the microbial processes of N2O production and consumption, thus it is also recommended for use in environments other than soilless substrates.

Phytotoxicity of Chemical Compounds from Cinnamomum camphora Pruning Waste in Germination and Plant Cultivation.

Much previous research has indicated most composts of pruning waste are characterized by potential phytotoxicity, it is highly correlated with the chemical compounds of raw materials. Cinnamomum camphora, a common kind of pruning waste in Southeast Asia and East Asia, is characterized by intense bioactivities due to complex chemical components. This study investigated the potential phytotoxicity of C. camphora pruning waste in light of germination and higher plant growth. C. camphora extracted from leaves completely inhibited seed germination and still showed suppression of root elongation at an extremely low dosage. C. camphora extract also displayed significant inhibition of nutrient absorption in tomato seedlings, including moisture, available nutrients (N, P and K) and key microelements (Fe, Mn, Zn and S). The gene expression of aquaporins and transporters of nitrate and phosphate was significantly up-regulated in roots. This could be regarded as a positive response to C. camphora extract for enhancing nutrient absorption. Moreover, the severe damage to the plasma membrane in roots caused by C. camphora extract might seriously affect nutrient absorption. Camphor is the main component of the C. camphora extract that may induce the phytotoxicity of plasma membrane damage, resulting in the inhibition of nutrient absorption and low biomass accumulation. This study provided a new understanding of the ecotoxicological effects of C. camphora pruning waste, indicating that the harmless disposal of pruning waste requires much attention and exploration in the future.

Steam-Exploded Pruning Waste as Peat Substitute: Physiochemical Properties, Phytotoxicity and Their Implications for Plant Cultivation.

Peat is a nonrenewable resource that we are using at alarming rates. Development of peat alternative from pruning waste (PW) could be a cost- and environment-friendly way of disposal. Steam explosion (SE) is a commonly used pretreatment of lignocellulosic biomass, but its impact on the properties of PW as a growing substrate is largely unknown. To address this issue, PW was treated using five SE temperatures (160, 175, 190, 205 and 220 °C) and three retention times (1, 3 and 5 min) and evaluated for key traits of growing substrate. Results indicate that bulk density, total porosity, EC, total carbon, and concentration of phytotoxins including phenol, flavonoid, and alkaloid significantly increased or tended to increase with increasing temperature and/or retention time. A reversed trend was observed for water-holding capacity, pH, content of hemicellulose and lignin, and germination index. Cation exchange capacity and total N showed minimal response to SE. Steam explosion had inconsistent impacts on acid soluble nutrients. Phytotoxicity was a major factor limiting the use of SE-treated PW as growing substrate. Higher pretreatment severity led to higher phytotoxicity but also facilitated subsequent phytotoxicity removal by torrefaction. Pruning waste treated by SE and torrefaction under certain conditions may be used as peat substitute for up to 40% (v/v).

Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study.

AIMS: Galectin-3, a ß-galactoside-binding lectin, is abnormally increased in cardiovascular disease. Plasma Galectin-3 receives a Class II recommendation for heart failure management and has been extensively studied for multiple cellular functions. The direct effects of Galectin-3 on platelet activation remain unclear. This study explores the direct effects of Galectin-3 on platelet activation and thrombosis. METHODS AND RESULTS: A strong positive correlation between plasma Galectin-3 concentration and platelet aggregation or whole blood thrombus formation was observed in patients with coronary artery disease (CAD). Multiple platelet function studies demonstrated that Galectin-3 directly potentiated platelet activation and in vivo thrombosis. Mechanistic studies using the Dectin-1 inhibitor, laminarin, and Dectin-1-/- mice revealed that Galectin-3 bound to and activated Dectin-1, a receptor not previously reported in platelets, to phosphorylate spleen tyrosine kinase and thus increased Ca2+ influx, protein kinase C activation, and reactive oxygen species production to regulate platelet hyperreactivity. TD139, a Galectin-3 inhibitor in a Phase II clinical trial, concentration dependently suppressed Galectin-3-potentiated platelet activation and inhibited occlusive thrombosis without exacerbating haemorrhage in ApoE-/- mice, which spontaneously developed increased plasma Galectin-3 levels. TD139 also suppressed microvascular thrombosis to protect the heart from myocardial ischaemia-reperfusion injury in ApoE-/- mice. CONCLUSION: Galectin-3 is a novel positive regulator of platelet hyperreactivity and thrombus formation in CAD. As TD139 has potent antithrombotic effects without bleeding risk, Galectin-3 inhibitors may have therapeutic advantages as potential antiplatelet drugs for patients with high plasma Galectin-3 levels.

Constructed microalgal-bacterial symbiotic (MBS) system: Classification, performance, partnerships and perspectives.

The microalgal-bacterial symbiotic (MBS) system shows great advantages in the synchronous implementation of wastewater treatment and nutrient recovery. To enhance the understanding of different MBS systems, this review summarizes reported MBS systems and proposes three patterns according to the living state of microalgae and bacteria. They are free microalgal-bacterial (FMB) system, attached microalgal-bacterial (AMB) system and bioflocculated microalgal-bacterial (BMB) system. Compared with the other two patterns, BMB system shows the advantages of microalgal biomass harvesting and application. To further understand the microalgal-bacterial partnerships in the bioflocculation of BMB system, this review discusses bioflocs characteristics, extracellular polymeric substances (EPS) properties and production, and the effect of microalgae/bacteria ratio and microalgal strains on the formation of bioflocculation. Microalgal biomass production and application are important for BMB system development in the future. Food processing wastewater characterized by high biodegradability and low toxicity should be conducive for microalgal cultivation. In addition, exogenous addition of functional bacteria for nutrient removal and bioflocculation formation would be a crucial research direction to facilitate the large-scale application of BMB system.

NOD2-mediated P2Y12 upregulation increases platelet activation and thrombosis in sepsis.

BACKGROUND: Platelets from septic patients exhibit increased reactivity. However, the underlying mechanism of sepsis-induced platelet hyperactivity is still not completely understood. OBJECTIVE: P2Y12 is a central receptor for platelet activation. In this study, we investigated the role of platelet P2Y12 in platelet hyperactivity during sepsis. METHODS: We measured platelet P2Y12 expression and aggregation in response to ADP in septic patients and cecal ligation and puncture (CLP)-treated mice. We also detected the downstream signaling of P2Y12 in resting platelets from patients and mice with sepsis. The role of nucleotide-binding oligomerization domain 2 (NOD2)/RIP2/NF-κB/P65 pathway in sepsis-induced platelet P2Y12 high expression was also investigated. Finally, we compared the antiplatelet and antithrombotic effects of clopidogrel, prasugrel, and ticagrelor in experimental sepsis in mice and rats. RESULTS: Compared to healthy subjects, platelets from septic patients exhibit P2Y12 hyperactivity and higher P2Y12 expression. pAkt is enhanced and pVASP is impaired in resting platelets from the patients, indicating the constitutive activation of platelet P2Y12 receptor. Mouse sepsis model recapitulates the findings in septic patients. NOD2 deficiency attenuates sepsis-induced platelet P2Y12 high expression, hyperactivity, and thrombosis. Prasugrel and ticagrelor are potent P2Y12 inverse agonists, and exhibit superior antiplatelet and antithrombotic efficacy over clopidogrel in mice and rats with sepsis. CONCLUSIONS: NOD2 activation upregulates platelet P2Y12 expression, which is constitutively activated and contributes to platelet hyperactivity in septic status. Compared to clopidogrel, prasugrel and ticagrelor are potent P2Y12 inverse agonists with superior antiplatelet and antithrombotic efficacy in experimental sepsis.

Fuel properties and combustion behaviors of fast torrefied pinewood in a heavily loaded fixed-bed reactor by superheated steam.

Superheated steam (SHS) was capable of fast and uniformly torrefying heavily loaded biomass. This work detailedly investigated the torrefied biomass in terms of fuel property and combustion behavior. The reactor chamber (300 ml) was fully loaded with pinewood pellets (160 g). Overall residence times were 20, 40 and 60 min (including preheating and holding periods) under 225, 275 and 325 °C. Biomass was estimated by elements, TG, FTIR, HHV, fuel property, combustion and pyrolysis behaviors, combustion kinetics and moisture reabsorption. Holding period as short as 2 min at 325 °C with a heating rate of 15 °C‧min-1 was found to enhance energy density by 45% and generated homogeneous coal-like products with HHV of 26.76 MJ‧kg-1. Fixed carbon content increased to 64.84 wt%. The combustion activation energy increased to 79.66 kJ‧mol-1. Combustion indices and behaviors indicated that torrefied biomass had benign characteristics either for co-firing or as fuel. All suggests good potential of SHS torrefaction to obtain fuel alternatives.

Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.

Camptothecin (CPT) is a cytotoxic quinoline alkaloid isolated from the bark and branches of the Chinese tree Camptotheca acuminata. CPT inhibits topoisomerase I. It possesses various antitumor activities and is mainly used in the treatment of colon, ovarian, liver, and bone cancers as well as leukemia. CPT inhibits the expressions of inflammatory genes and can prevent death from chronic inflammation. Therefore, we investigated the effect of CPT treatment in ulcerative colitis (UC) using DSS-induced UC mouse model; after that, we explored its potential mechanisms. Here, we found that CPT exerted protection on DSS-induced UC in rats. In addition, the administration prominently reduced the disease activity index as well as colon length of the model rats and remarkably reduced the inflammatory cytokines. Further, CPT significantly reduced several vital proinflammatory proteins in LPS-induced RAW264.7 cells. In summary, our findings demonstrate that CPT is hopefully to act as a therapeutic agent for UC.

Superheated steam as carrier gas and the sole heat source to enhance biomass torrefaction.

Superheated steam (SHS) has been used as a carrier gas for pressurized steam torrefaction, steam explosion or pyrolysis, but is barely used as a heat source. However, SHS is superior in thermal capacity and heat transfer coefficient resulting in even heating and fast heating rates. Therefore, this work applied SHS as the sole heat source for torrefaction at ambient pressure. A setup was specially designed and capable of heating wood shavings at a rate >120 °C•min-1. Solid products were analyzed in many aspects and demonstrated the enhanced organics conversion owing to SHS torrefaction. Torrefied biomass was comparable to slow pyrolysis char in fuel quality and superior to that of conventional torrefactions. Moreover, SHS torrefaction was super-timesaving. A coal-like product (HHV of 27.84 MJ•kg-1) was achieved in only 15 min at 350 °C. Overall, SHS torrefaction boosted biomass densification and gaveriseto greater production efficiency.

Current status of the diagnosis and treatment of gastrointestinal schwannoma.

Gastrointestinal schwannoma is a rare, slow-growing and benign tumor that mostly originates in the Auerbach myenteric nerve plexus in the gastrointestinal tract. The clinical manifestations may be associated with the location, size, differentiation type, and degree of malignancy of the tumor. Endoscopy, ultrasound and imaging examinations serve an important auxiliary role in the clinical identification, diagnosis and differential diagnosis of lesions; assessment of risk; and preparation for surgery. S-100 positivity is a hallmark of schwannoma. CD34, CD117, discovered on GIST-1, P53, ALK, ß-catenin, smooth muscle actin and Desmin negativity are helpful for the identification of other gastrointestinal stromal tumors. Surgical removal of the tumor is the main treatment for schwannoma. Benign gastrointestinal schwannoma has a good prognosis without recurrence and metastasis; malignant transformation is extremely rare and has a poor prognosis.

PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.

BACKGROUND: PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into the blood, elevates plasma low-density lipoprotein cholesterol by degrading low-density lipoprotein receptor. Pleiotropic effects of PCSK9 beyond lipid metabolism have been shown. However, the direct effects of PCSK9 on platelet activation and thrombosis, and the underlying mechanisms, as well, still remain unclear. METHODS: We detected the direct effects of PCSK9 on agonist-induced platelet aggregation, dense granule ATP release, integrin αIIbß3 activation, α-granule release, spreading, and clot retraction. These studies were complemented by in vivo analysis of FeCl3-injured mouse mesenteric arteriole thrombosis. We also investigated the underlying mechanisms. Using the myocardial infarction (MI) model, we explored the effects of PCSK9 on microvascular obstruction and infarct expansion post-MI. RESULTS: PCSK9 directly enhances agonist-induced platelet aggregation, dense granule ATP release, integrin αIIbß3 activation, P-selectin release from α-granules, spreading, and clot retraction. In line, PCSK9 enhances in vivo thrombosis in a FeCl3-injured mesenteric arteriole thrombosis mouse model, whereas PCSK9 inhibitor evolocumab ameliorates its enhancing effects. Mechanism studies revealed that PCSK9 binds to platelet CD36 and thus activates Src kinase and MAPK (mitogen-activated protein kinase)-extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase, increases the generation of reactive oxygen species, and activates the p38MAPK/cytosolic phospholipase A2/cyclooxygenase-1/thromboxane A2 signaling pathways downstream of CD36 to enhance platelet activation, as well. Using CD36 knockout mice, we showed that the enhancing effects of PCSK9 on platelet activation are CD36 dependent. It is important to note that aspirin consistently abolishes the enhancing effects of PCSK9 on platelet activation and in vivo thrombosis. Last, we showed that PCSK9 activating platelet CD36 aggravates microvascular obstruction and promotes MI expansion post-MI. CONCLUSIONS: PCSK9 in plasma directly enhances platelet activation and in vivo thrombosis, and MI expansion post-MI, as well, by binding to platelet CD36 and thus activating the downstream signaling pathways. PCSK9 inhibitors or aspirin abolish the enhancing effects of PCSK9, supporting the use of aspirin in patients with high plasma PCSK9 levels in addition to PCSK9 inhibitors to prevent thrombotic complications.

Rooting ability of rice seedlings increases with higher soluble sugar content from exposure to light.

Rooting ability of rice seedling for mechanical transplanting has a large impact on grain yield. This study explored the relationship between endogenous soluble sugar content and rooting ability of rice seedlings. We placed 15-day-old rice seedlings in controlled environment cabinets with stable light and sampled after 0, 3, 6, 9, 12, and 24 hours of light to measure their soluble sugar content, nitrate content, starch content, soluble protein content and rooting ability. The soluble sugar content of the rice seedlings before rooting increased rapidly from 65.1 mg g-1 to 126.3 mg g-1 in the first 9 hours of light and then tended to stabilize; however, few significant changes in the other physiological indices were detected. With the light exposure time increasing from 3 hours to 12 hours, the rooting ability measured with fresh weight, dry weight, total length, and number of new roots increased by 91.7%, 120.0%, 60.6% and 30.3%, respectively. Rooting ability was related more closely to soluble sugar content than to nitrate-nitrogen content of rice seedlings before rooting and their correlation coefficients were 0.8582-0.8684 and 0.7045-0.7882, respectively. The stepwise regression analysis revealed that the soluble sugar content before rooting explained 73.6%-75.4% of the variance, and the nitrate-nitrogen content explained an additional 7.3%-14.2% of the variance in rooting ability, indicating that compared with nitrate-nitrogen content, soluble sugar content of rice seedlings before rooting was more dominant in affecting rooting ability. This study provides direct evidence of the relationship between the rooting ability and endogenous soluble sugar content of rice seedlings.

Author Correction: Effects of applying ramie fiber nonwoven films on root-zone soil nutrient and bacterial community of rice seedlings for mechanical transplanting.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

A stricter control of low-density lipoprotein is necessary for thrombosis reduction in "lower thrombosis risk" patients with atrial fibrillation: a multicenter retrospective cohort study.

Patients with atrial fibrillation (AF) are associated with increased thrombotic events. Our previous case-control study showed low-density lipoprotein cholesterol (LDL-C) was an independent predictor of ischemic stroke in AF patients. To investigate the risks of thrombosis in relation to LDL-C among AF patients at different stroke risks by long-time follow-up. Atrial fibrillation patients without history of thrombosis enrolled from five hospitals were classified into low-risk (LR) and high-risk (HR) group according to CHA2DS2VASc score and followed up with a median period of 26 months. Univariate and multivariate logistic regression analysis were performed in each group. The best cut-off value calculated by receiver operating characteristic (ROC) analysis was used to divide patients into low LDL-C (L-LDL) and high LDL-C (H-LDL) subgroups. Propensity score matching (PSM) and inverse probability of treatment weighted (IPTW) were utilized in both subgroups, after which Kaplan-Meier curves for thrombosis were performed. Univariate and multivariate analysis showed LDL-C was significantly related to thrombosis in LR, but less significantly in HR group. The best cut-off value was 2.155 mmol/L in LR and 2.795 mmol/L in HR group. Lower LDL-C was associated with decreased thrombosis in both groups by PSM and IPTW. Kaplan-Meier curves displayed that H-LDL subgroup was at higher thrombosis risk with significant difference at 24th month in LR patients. LDL-C independently predicts thrombosis with different cut-off values in AF patients at different risks. A stricter control of LDL-C level is necessary for thrombosis reduction in patients with lower score.