Since 2015, edaravone is the second drug available for the treatment of Amyotrophic lateral sclerosis (ALS). In this study we analyzed the characteristics and experience of ALS patients treated with this new medication in our country. Sixteen ALS patients were treated with edaravone infusions in three ALS clinics. Most of them were male, had a spinal onset of the disease and a definite diagnosis of ALS. Mean age at first infusion was 53.5 years. Since the diagnosis of ALS, delay in starting treatment with edaravone was five times greater than that of riluzole. Edaravone therapy was usually initiated at a health care facility and was followed by domiciliary cycles. Adverse effects and the need of a special catheter for infusion were rare. Access to edaravone through health insurance was possible in only 43.8% of patients. Altogether, treatment access was limited but feasible and edaravone was well tolerated.
Amyotrophic Lateral Sclerosis/drug therapy , Amyotrophic Lateral Sclerosis/epidemiology , Edaravone/administration & dosage , Neuroprotective Agents/administration & dosage , Adult , Aged , Argentina/epidemiology , Drug Administration Routes , Female , Humans , Male , Middle Aged
The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40% lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32%) and experimental groups (about 66%). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.
Glucan 1,4-alpha-Glucosidase/therapeutic use , Glucose Oxidase/therapeutic use , Stomatitis, Aphthous/drug therapy , Toothpastes/therapeutic use , Adolescent , Adult , Child , Double-Blind Method , Female , Humans , Male , Middle Aged , Toothpastes/chemistry , Treatment Outcome
The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40
lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32
) and experimental groups (about 66
). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.
The aim of this study was to assess whether a toothpaste containing amyloglucosidase and glucose oxidase (Z) provoked any effect on minor recurrent aphthous ulcers, (RAU) as compared with a placebo toothpaste (P). Twenty patients (11 females), suffering from minor RAU, participated in this study during a period of 15 weeks. The patients brushed their teeth twice a day with the toothpaste. They were examined once a week to monitor the number and size of ulcers. The mean number of ulcers in both groups was about 40
lower than that found before treatment. Ulcer mean diameter had also decreased in both the placebo (about 32
) and experimental groups (about 66
). There were no statistically significant differences between the two groups in number of weeks with ulcers, in total number of ulcers per patient, and in mean diameter of the ulcers. In conclusion, no significant differences in therapeutic effects could be shown between treatments with Z and P.
The prevalence of grooved tongue, geographic tongue, and ankyloglossia, was investigated in 660 children, 3 to 13 years old, which attended the Out patient Clinic of the University Hospital of Buenos Aires for unrelated complaints. The figures obtained are at variance--by far--from those published by other people engaged in the same line of research. Probably, further studies with a much larger amount of patients are called for.
Tongue Diseases/epidemiology , Adolescent , Argentina/epidemiology , Child , Child, Preschool , Female , Glossitis, Benign Migratory/epidemiology , Humans , Lingual Frenum/abnormalities , Male , Tongue, Fissured/epidemiology
The prevalence of grooved tongue, geographic tongue, and ankyloglossia, was investigated in 660 children, 3 to 13 years old, which attended the Out patient Clinic of the University Hospital of Buenos Aires for unrelated complaints. The figures obtained are at variance--by far--from those published by other people engaged in the same line of research. Probably, further studies with a much larger amount of patients are called for.
The prevalence of grooved tongue, geographic tongue, and ankyloglossia, was investigated in 660 children, 3 to 13 years old, which attended the Out patient Clinic of the University Hospital of Buenos Aires for unrelated complaints. The figures obtained are at variance--by far--from those published by other people engaged in the same line of research. Probably, further studies with a much larger amount of patients are called for.
The aim of this survey was to determine the prevalence of oral mucosa lesions in children aged 4-13 yr from two schools, one (S1) having a higher socioeconomic status than the other (S2). In all, 846 children were examined, 463 from S1 and 383 from S2, of whom 555 were boys and 291 were girls. There were 359 boys and 104 girls in S1; 196 boys and 187 girls in S2. Fifteen different lesion types were discerned. The most frequent ones were recurrent aphthous ulceration (RAU) (92 cases); fissured cheilitis (54); herpes labialis (44); angular cheilitis (30); geographic tongue (25); smooth tongue (22); and plicated tongue (17). An outstanding finding was the contrasting distribution of certain lesion types in the two schools. RAU was observed in 19% of the children from S1, making up 50% of all lesions detected. However, in S2 only 2% exhibited RAU, making up less than 4% of observed lesions. On the other hand, herpes labialis was seen in 1% of S1 and 10% of S2 children, regardless of age or sex. Plicated tongue was found in 3.2% in S1 and 0.5% in S2; fissured cheilitis in 2.9% in S1 and 12.8% in S2; and angular cheilitis in 1.1% in S1 and 6.5% in S2. Therefore, there were no statistical differences between the schools in the ratio of total lesions observed to children examined, but a significant difference was apparent when individual lesions were taken into account.
Mouth Diseases/epidemiology , Social Class , Adolescent , Argentina , Child , Child, Preschool , Female , Humans , Income , Male , Mouth Diseases/pathology , Mouth Mucosa/pathology , Rural Population , Stomatitis, Aphthous/epidemiology , Stomatitis, Aphthous/pathology , Urban Population
