1.
J Med Chem
; 50(20): 4789-92, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17850061
RESUMEN
A 1,3,4-benzotriazepine was identified as a suitable lead in our effort toward obtaining a non-peptide parathyroid hormone-1 receptor (PTH1R) antagonist. A process of optimization afforded derivatives displaying nanomolar PTH1R affinity, a representative example of which behaved as a PTH1R antagonist in cell-based cyclic adenosine monophosphate (cAMP) assays, with selectivity over PTH2 receptors.