Perceived Covid-19-crisis intensity and family supportive organizational perceptions as antecedents of parental burnout: A study conducted in Italy in March/April 2021 and 2022.

The purpose of this study is to investigate to what extent perceived Covid-19-crisis intensity (PCCI) leads to the experience of parental burnout (PB), a syndrome characterized by exhaustion, emotional detachment from one's own children and a sense of inefficacy in the role as parent. Furthermore, the mediating role of work-family conflict (WFC) is examined. The buffering effect of family supportive organizational perceptions during the pandemic (FSOP-p) on the relationship between work-family conflict and parental burnout is also explored. Data were collected in March-April 2021 and March/April 2022. In spring 2021, 222 Italian working parents with at least one minor child living at home filled out the questionnaire. Data from 2021 showed that PCCI was positively related to the experience of parental burnout. Moreover, WFC mediated this relationship. No significant interaction effect was found for FSOP-p; however it was found that FSOP-p is negatively related to PCCI and WFC, and indirectly to parental burnout. In spring 2022, we examined whether there were changes in PCCI, WFC, and FSOP-p in a sample of 83 Italian parents. Moreover, for the second data collection we examine the tensions experienced by parents in their families about vaccination and infection precaution measures (e.g., Covid-19 vaccination passport). The results are different in 2022; the effect of PCCI on parental burnout is now completely mediated by the amount of WFC. It seems that now we go 'back to normal' and homeworking has become more optional for many, there is still an effect of PCCI on WFC, but no longer directly on parental burnout. Furthermore, the prevalence of PCCI in 2022 is lower than in 2021, while WFC and FSOP-p are not significantly different between the two timepoints. As family supportive organizational perceptions reduce the level of perceived Covid-19 intensity, organizations are urged to develop practices of support and to create a supportive environment.

The Methylation of Clock Genes in Perinatal Depression: Which Role for Oxytocin?

Background: Perinatal Depression (PD) is a widespread disabling condition that is hypothesized to be associated with abnormalities in circadian rhythms and neuropeptide release including oxytocin (OXT). Methods: Fourty-four pregnant women (28 with PD, and 16 controls) were evaluated through the Edinburgh Postnatal Depression Scale (EPDS), the State/Trait Anxiety Inventory Form Y (STAI-Y), and the Prenatal Attachment Inventory (PAI). A blood sample was collected from all participants, and OXT plasma levels, DNA methylation of clock genes, as well as of FOXp3 and HERV-W were measured. Linear regression analyses were performed to assess the effect of oxytocin on the methylation of selected genes. Continuous ordinal regression models was further applied to see if the score of rating scales was associated to gene methylation, adjusting for oxytocin-methylation interaction. Results: OXT plasma levels were positively associated with CRY1 methylation. Women with higher OXT plasma levels showed an association between higher degree of CRY2 methylation (thus, reduced expression) and lower EPDS (OR = 0.21; P = 0.043) and STAI-S scores (OR = 6.96; P = 0.019). Finally, with high OXT levels, hypermethylation of CRY1 was associated to higher scores on the PAI (OR = 2.74; P = 0.029) while higher methylation of HERV-W related to lower PAI scores (OR = 0.273; P = 0.019). Conclusion: Our results suggest a possible protective role played by oxytocin in the development of PD by promoting a favorable methylation profile characterized by reduced expression of CRY1 and CRY2. Moreover, oxytocin strengthens the association between maternal prenatal attachment with a favorable pattern of methylation of clock genes and HERV-W, which is essential for pregnancy outcomes.

Is There an Association Between Oxytocin Levels in Plasma and Pregnant Women's Mental Health?

BACKGROUND: Mood and anxiety disorders are prevalent in women during peripartum. AIMS: Purpose of the present article was to study the relationship between oxytocin (OT) plasma levels and affective symptoms in women during the third trimester of pregnancy. METHODS: Thirty-four pregnant women (13 with an affective disorder, 9 with preeclampsia, and 12 controls) were evaluated through the Edinburgh Postnatal Depression Scale (EPDS), the State/Trait Anxiety Inventory Form Y (STAI-Y), and the Prenatal Attachment Inventory (PAI). A blood sample was collected from all participants, and OT plasma levels have been compared between diagnostic groups. The total sample has been divided into two groups, according to OT median plasma levels, and compared using (a) χ2 tests for qualitative variables and (b) a multivariate analysis of covariance for quantitative ones. RESULTS: No statistically significant difference was found among the diagnostic groups in terms of OT plasma levels (F = 0.49, p = .62). Women with lower OT plasma levels, independent from the presence of preeclampsia or an affective disorder, showed worse EPDS and STAI-S total scores than individuals with higher hormone levels (F = 5.93, p = .02 and F = 7.57, p = .01, respectively). CONCLUSIONS: OT may play a role in the etiology of anxious/depressive symptoms during perinatal period independent from a medical or psychiatric diagnosis. This result has a clear effect on the quality of the relationship of patients with mental health professionals, including nurses, and higher levels of this hormone, in the light of its anxiolytic and antidepressive effect, may make easier medical and nursing procedures.