The lived experience of UERMMMCI student nurses: The untold stories of home confinement during the first 3 months of COVID-19 lockdown / The Health Sciences Journal

INTRODUCTION@#The COVID-19 pandemic has forced countries to impose lockdowns. The aim of the study was to explore lived experiences of student nurses during their home confinement and acquire the shared meaning of the phenomenon among the participants. In this study, the researchers explored the impact of home confinement on student nurses to gain a thorough understanding of their perceived experiences, including their personal feelings, responses to the pandemic and learnings. @*METHODS@#The researchers used a descriptive phenomenological approach, wherein student nurses from all levels were selected through purposive sampling and were interviewed one on one through Zoom using a semi-structured open-ended questionnaire. The researchers utilized Colaizzi’s method of analysis to extract their lived experiences during their home confinement during the first three months of COVID-19 lockdown. @*RESULTS@#The results resulted in eight themes: Delighted, Attitude Towards the Disease, Home Isolation, Situational Awareness, Stronger Connection, Adaptation to Change, Role Function, Psychological Development and Outlook.@*CONCLUSION@#Based on Sister Callista Roy’s Adaptation Model Theory, there is a direct relationship between the stimuli, coping and behavior of the participants.

Hippocampal synaptic dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis: Reversal by adenosine A2AR blockade.

Amyotrophic Lateral Sclerosis (ALS) mostly affects motor neurons, but non-motor neural and cognitive alterations have been reported in ALS mouse models and patients. Here, we evaluated if time-dependent biphasic changes in synaptic transmission and plasticity occur in hippocampal synapses of ALS SOD1G93A mice. Recordings were performed in hippocampal slices of SOD1G93A and age-matched WT mice, in the pre-symptomatic and symptomatic stages. We found an enhancement of pre-synaptic function and increased adenosine A2A receptor levels in the hippocampus of pre-symptomatic mice. In contrast, in symptomatic mice, there was an impairment of long-term potentiation (LTP) and a decrease in NMDA receptor-mediated synaptic currents, with A2AR levels also being increased. Chronic treatment with the A2AR antagonist KW-6002, rescued LTP and A2AR values. Altogether, these findings suggest an increase in synaptic function during the pre-symptomatic stage, followed by a decrease in synaptic plasticity in the symptomatic stage, which involves over-activation of A2AR from early disease stages.