RESUMEN
Chronic intake of Sr for 20 days by chickens caused in them a delay in body mass increase and symptoms of rickets in spite of complete provision with vitamin D. There were low levels of Ca, P, enhanced activity of alkaline phosphatase in the serum, inhibited mineralization of bone tissue, reduced levels of vitamin D-dependent calcium-binding protein, Sr accumulation in various tissues. Enrichment with Ca of the chickens ration diminished the above signs of Sr toxicosis. It is suggested that a protective effect of Ca in chronic Sr toxicity may be due to more active discrimination of Sr against Ca in intestinal assimilation of these cations.
Asunto(s)
Calcio de la Dieta/farmacología , Estroncio/toxicidad , Animales , Calcio de la Dieta/administración & dosificación , Calcio de la Dieta/metabolismo , Pollos , Trastornos del Crecimiento/inducido químicamente , Trastornos del Crecimiento/prevención & control , Hipofosfatemia Familiar/inducido químicamente , Hipofosfatemia Familiar/prevención & control , Estroncio/metabolismoRESUMEN
The action of 1 alpha-hydroxycholecalciferol (oxydevit) was estimated in 204 patients with renal osteodystrophy, osteoporosis of varying etiology, osteomalacia because of malabsorption, congenital rickets-like diseases. The drug was shown to be highly effective in the treatment of secondary hyperparathyroidism in uremia, steroidal and senile osteoporosis. The treatment involved replacement therapy.
Asunto(s)
Enfermedades Óseas Metabólicas/tratamiento farmacológico , Hidroxicolecalciferoles/uso terapéutico , Enfermedades Óseas Metabólicas/metabolismo , Evaluación de Medicamentos , Femenino , Humanos , Osteomalacia/tratamiento farmacológico , Osteomalacia/metabolismo , Osteoporosis/tratamiento farmacológico , Osteoporosis/metabolismo , Osteoporosis Posmenopáusica/tratamiento farmacológico , Osteoporosis Posmenopáusica/metabolismo , Raquitismo/congénito , Raquitismo/tratamiento farmacológico , Raquitismo/metabolismoRESUMEN
The paper is concerned with the results of therapy of a severe form of postmenopausal osteoporosis in 5 patients using the combination of estrogens, 1-alpha-hydroxycholecalciferol and calcitonin. The treatment with the above drugs was accompanied by marked improvement of the general status. It was characterized by an increase in daily calcium excretion with urine, normalization of the concentration of calcium, inorganic phosphorus and serum alkaline phosphatase activity. A conclusion was made that the combined use of estrogens and 1-alpha-hydroxycholecalciferol produced a more marked clinical effect than each drug separately.