Asunto(s)
Dermatitis , Liquen Plano , Humanos , Alopecia/etiología , Linfocitos , Factor de Transcripción STAT3RESUMEN
Central centrifugal cicatricial alopecia (CCCA) is a form of scarring alopecia that predominantly affects middle-aged women of African descent. Recent data suggest a multifactorial etiology of CCCA that is influenced by environmental and genetic factors. Emerging evidence regarding the genetic basis of the condition may elucidate new therapies. While topical and intralesional steroids and tetracycline antibiotics are the mainstay of treatment, refractory cases may be considered for hair transplantation. Emerging therapies using platelet-rich plasma, botanical formulas, and cosmetic procedures have shown promising results for the future management of CCA. As recent notable advances in CCCA have been achieved, this review provides an update on the epidemiology, pathophysiology, and management of CCCA.
Asunto(s)
Alopecia , Femenino , Humanos , Persona de Mediana Edad , Alopecia/patología , Cicatriz/patologíaRESUMEN
Central centrifugal cicatricial alopecia (CCCA) is a common cause of hair loss among patients of African and/or Caribbean descent, and there is little data exploring the quality of life of patients with this condition. This pilot demonstrates that CCCA has a significant impact on overall quality of life, and patients may benefit from resources to address psychosocial aspects of this diagnosis.
Asunto(s)
Dermatitis , Calidad de Vida , Humanos , Negro o Afroamericano , Alopecia/diagnóstico , Alopecia/etiología , Cicatriz/etiología , Población NegraAsunto(s)
Alopecia , Dermatitis , Alopecia/etiología , Alopecia/patología , Cicatriz/etiología , Cicatriz/patología , Dermatitis/patología , Cabello/patología , HumanosRESUMEN
Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in Vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease. This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome.
Asunto(s)
Inmunidad Innata , Piel/inmunología , Vitamina A/inmunología , Animales , Dermatitis , Humanos , Microbiota/fisiología , Piel/microbiología , Staphylococcus aureus/efectos de los fármacos , Tretinoina , Vitamina A/farmacología , Deficiencia de Vitamina AAsunto(s)
Alopecia/complicaciones , Neoplasias de la Mama/epidemiología , Cicatriz/complicaciones , Neoplasias Colorrectales/epidemiología , Adolescente , Adulto , Negro o Afroamericano/estadística & datos numéricos , Anciano , Alopecia/patología , Biopsia , Neoplasias de la Mama/diagnóstico , Neoplasias de la Mama/etiología , Neoplasias de la Mama/patología , Cicatriz/patología , Colonoscopía/estadística & datos numéricos , Neoplasias Colorrectales/diagnóstico , Neoplasias Colorrectales/etiología , Neoplasias Colorrectales/patología , Estudios Transversales , Femenino , Humanos , Mamografía/estadística & datos numéricos , Persona de Mediana Edad , Pennsylvania/epidemiología , Proyectos Piloto , Prevalencia , Arginina Deiminasa Proteína-Tipo 3/metabolismo , Estudios Retrospectivos , Adulto JovenAsunto(s)
Alopecia/patología , Células Epiteliales/patología , Folículo Piloso/patología , Queratina-15/metabolismo , Células Madre/patología , Cicatriz/diagnóstico , Cicatriz/patología , Células Epiteliales/ultraestructura , Fibrosis/diagnóstico , Fibrosis/patología , Folículo Piloso/ultraestructura , Humanos , Liquen Plano/inmunología , Liquen Plano/patología , Lupus Eritematoso Discoide/inmunología , Lupus Eritematoso Discoide/patología , Microscopía Fluorescente/métodos , Células Madre/citología , Células Madre/inmunologíaRESUMEN
Induction of persistent HIV-1 Envelope (Env) specific antibody (Ab) is a primary goal of HIV vaccine strategies; however, it is unclear whether HIV Env immunization in humans induces bone marrow plasma cells, the presumed source of long-lived systemic Ab. To define the features of Env-specific plasma cells after vaccination, samples were obtained from HVTN 105, a phase I trial testing the same gp120 protein immunogen, AIDSVAX B/E, used in RV144, along with a DNA immunogen in various prime and boost strategies. Boosting regimens that included AIDSVAX B/E induced robust peripheral blood plasmablast responses. The Env-specific immunoglobulin repertoire of the plasmablasts is dominated by VH1 gene usage and targeting of the V3 region. Numerous plasmablast-derived immunoglobulin lineages persisted in the bone marrow >8 months after immunization, including in the CD138+ long-lived plasma cell compartment. These findings identify a cellular linkage for the development of sustained Env-specific Abs following vaccination in humans.
Asunto(s)
Vacunas contra el SIDA/uso terapéutico , Infecciones por VIH/prevención & control , Células Plasmáticas/inmunología , Productos del Gen env del Virus de la Inmunodeficiencia Humana/inmunología , Especificidad de Anticuerpos , Linaje de la Célula/inmunología , Supervivencia Celular/inmunología , Células Cultivadas , Células HEK293 , Infecciones por VIH/patología , Infecciones por VIH/virología , VIH-1/inmunología , VIH-1/fisiología , Humanos , Células Plasmáticas/metabolismo , Células Plasmáticas/patología , Células Plasmáticas/virología , Células THP-1 , VacunaciónRESUMEN
Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia that primarily affects women of African descent. Although histopathological features of CCCA have been described, the pathophysiology of this disease remains unclear. To better understand the components of CCCA pathophysiology, we evaluated the composition of the inflammatory infiltrate, the distribution of Langerhans cells (LCs), and the relationship between fibrosis and perifollicular vessel distribution. Our data indicate that CCCA is associated with a CD4-predominant T-cell infiltrate with increased LCs extending into the lower hair follicle. Fibroplasia associated with follicular scarring displaces blood vessels away from the outer root sheath epithelium. These data indicate that CCCA is an inflammatory scarring alopecia with unique pathophysiologic features that differentiate it from other lymphocytic scarring processes.
