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Bioorg Med Chem Lett
; 16(20): 5384-8, 2006 Oct 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16890433
RESUMEN
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.