[HIV self-tests in community pharmacies Inventory and practice recommendations for interprofessional collaborations]. / Remise des autotests VIH en pharmacie d'officine. État des lieux et recommandations de pratique pour une collaboration interprofessionnelle.

The distribution of HIV self-tests in Swiss pharmacies has been authorized by Swissmedic since June 2018 for personal use. Self-testing is a screening tool recommended by the World Health Organisation (WHO) for people whose last risk situation was more than three months ago. No guideline for pharmacists has been developed by the Swiss competent authorities. This article proposes practical recommendations to be implemented in a logic of interprofessional collaboration.

La remise des autotests VIH dans les pharmacies suisses est autorisée par Swissmedic depuis juin 2018 pour un usage personnel. Les autotests représentent un outil de dépistage recommandé par l'OMS pour les personnes dont la dernière situation à risque remonte à plus de trois mois. À l'heure actuelle, aucune recommandation en matière de délivrance par les pharmacien-ne-s n'a été élaborée par les autorités compétentes en Suisse. Cet article propose des recommandations pratiques à mettre en œuvre dans un esprit de collaboration interprofessionnelle.

Artificial Metalloenzymes with the Neocarzinostatin Scaffold: Toward a Biocatalyst for the Diels-Alder Reaction.

A copper(II) cofactor coupled to a testosterone anchor, copper(II)-(5-(Piperazin-1-yl)-1,10-phenanthroline)testosterone-17-hemisuccinamide (10) was synthesized and associated with a neocarzinostatin variant, NCS-3.24 (KD =3 µm), thus generating a new artificial metalloenzyme by following a "Trojan horse" strategy. Interestingly, the artificial enzyme was able to efficiently catalyze the Diels-Alder cyclization reaction of cyclopentadiene (1) with 2-azachalcone (2). In comparison with what was observed with cofactor 10 alone, the artificial enzymes favored formation of the exo products (endo/exo ratios of 84:16 and 62:38, respectively, after 12 h). Molecular modeling studies assigned the synergy between the copper complex and the testosterone (KD =13 µm) moieties in the binding of 10 to good van der Waals complementarity. Moreover, by pushing the modeling exercise to its limits, we hypothesize on the molecular grounds that are responsible for the observed selectivity.