Asunto(s)
Glomerulonefritis/diagnóstico , Glomerulonefritis/virología , Hepatitis C/complicaciones , Hepatitis C/diagnóstico , Lupus Eritematoso Sistémico/diagnóstico , Adulto , Antivirales/uso terapéutico , Diagnóstico Diferencial , Femenino , Glomerulonefritis/tratamiento farmacológico , Hepatitis C/tratamiento farmacológico , Humanos , Inmunosupresores/uso terapéutico , Interferones/uso terapéutico , Metilprednisolona/uso terapéutico , Ribavirina/uso terapéutico , Resultado del TratamientoAsunto(s)
Glomerulonefritis Membranosa/tratamiento farmacológico , Inmunosupresores/efectos adversos , Sarcoma de Kaposi/tratamiento farmacológico , Sirolimus/análogos & derivados , Neoplasias Cutáneas/tratamiento farmacológico , Anciano , Biopsia con Aguja , Everolimus , Femenino , Estudios de Seguimiento , Glomerulonefritis Membranosa/complicaciones , Glomerulonefritis Membranosa/diagnóstico , Humanos , Inmunohistoquímica , Inmunosupresores/administración & dosificación , Pruebas de Función Renal , Sarcoma de Kaposi/inmunología , Sarcoma de Kaposi/patología , Índice de Severidad de la Enfermedad , Sirolimus/uso terapéutico , Neoplasias Cutáneas/inmunología , Neoplasias Cutáneas/patología , Resultado del TratamientoRESUMEN
Antibodies against monomeric C-reactive protein, which is a target antigen expressed both in kidney tubules and uveal cells, have been recently detected in patients with active tubulointerstitial nephritis and uveitis syndrome. We report the case of an 65-year-old woman with acute renal failure caused by biopsy-proven tubulointerstitial nephritis and the onset of uveitis 21 months later. The expression of monomeric C-reactive protein in kidney oligobiopsy was confirmed by immunohistochemical staining using mouse monoclonal antibody against human monomeric C-reactive protein. The levels of antibodies against monomeric C-reactive protein were 117% of the reference during the flare and 22% during the remission of the disease. The difference in the levels of antibodies against monomeric C-reactive protein during flare and remission, and above all positive biopsy staining, supports their pathogenic role in this disease.
