RESUMEN
This article explores the statistical methodologies used in demonstration and effectiveness studies when the treatments are applied across multiple settings. The importance of evaluating and how to evaluate these types of studies are discussed. As an alternative to standard methodology, the authors of this article offer an empirical binomial hierarchical Bayesian model as a way to effectively evaluate multisite studies. An application of using the Bayesian model in a real-world multisite study is given.
Asunto(s)
Teorema de Bayes , Interpretación Estadística de Datos , Investigación Empírica , Modelos Estadísticos , Estudios Multicéntricos como Asunto/métodos , Adolescente , Adulto , Distribución Binomial , Femenino , Humanos , Bienestar Materno , Embarazo , Atención Prenatal , Investigación , Fumar , Cese del Hábito de Fumar , Distribuciones EstadísticasRESUMEN
BACKGROUND: After the first two cases of locally-acquired HIV infection were recognized in Chuuk State, Federated States of Micronesia (FSM), a public health response was initiated. The purpose of the response was to assess the need for HIV education and prevention services, to develop recommendations for controlling further spread of HIV in Chuuk, and to initiate some of the prevention measures. METHODOLOGY/PRINCIPAL FINDINGS: A public health team conducted a survey and rapid HIV testing among a sample of residents on the outer islands in Chuuk. Local public health officials conducted contact tracing and testing of sex partners of the two locally-acquired cases of HIV infection. A total of 333 persons completed the survey. The majority knew that HIV is transmitted through unprotected sexual contact (81%), injection drug use (61%), or blood transfusion (64%). Sexual activity in the past 12 months was reported among 159 participants, including 90 females and 69 males. Compared to women, men were more likely to have had multiple sex partners, to have been drunk during sex, but less likely to have used a condom in the past 12 months. The two men with locally acquired HIV infection had unprotected anal sex with a third Chuukese man who likely contracted HIV while outside of Chuuk. All 370 persons who received voluntary, confidential HIV counseling and testing had HIV negative test results. CONCLUSIONS/SIGNIFICANCE: Despite the low HIV seroprevalence, risky sexual behaviors in this small isolated population raise concerns about the potential for rapid spread of HIV. The lack of knowledge about risks, along with stigmatizing attitudes towards persons infected with HIV and high risk sexual behaviors indicate the need for resources to be directed toward HIV prevention in Chuuk and on other Pacific Islands.
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Infecciones por VIH/prevención & control , Servicios Preventivos de Salud/organización & administración , Conducta Sexual , Poblaciones Vulnerables , Serodiagnóstico del SIDA , Consejo , Femenino , Infecciones por VIH/epidemiología , Conocimientos, Actitudes y Práctica en Salud , Humanos , Masculino , Micronesia/epidemiología , Factores de RiesgoAsunto(s)
Computadoras de Mano , Consejo/métodos , Dieta , Obesidad/prevención & control , Asistentes Médicos , Prevención del Hábito de Fumar , Adulto , Femenino , Humanos , MasculinoRESUMEN
Triangulation analysis was used to assess qualitative data collected to examine smoking cessation materials and methods prior to a large randomized clinical trial with pregnant smokers. The patient education program's components were tested with 265 patients receiving Medicaid-insured care in 9 public clinics. The formative evaluation process conducted during this pilot study of the Smoking Cessation and Reduction in Pregnancy Trial included assessment of A Pregnant Woman's Guide to Stop Smoking (Windsor et al., 2002), a companion video, clinic reinforcement, and patient-centered counseling. Focus groups were conducted, with 23 (82%) of the nurses and social workers who provided the intervention. Twenty-nine (20.8%) of the women who received the intervention were interviewed individually. The qualitative data were examined to identify convergence and divergence among and between providers and patients about presentation, use of components, and program impact. Findings were used to refine the intervention to enhance patient and staff receptivity, specifically to ensure participant comprehension and shorten time required of busy staff.