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BACKGROUND: Organ donation entails saving or transforming lives through the provision of organs, either from living donors or deceased individuals. In Jordan, low donation rates are attributed to religious misconceptions, limited education and insufficient awareness of the burden on patients with organ failure. OBJECTIVES: To investigate the attitudes of the Jordanian population towards the practicality and effectiveness of introducing an opt-out organ donation system through legislative measures, with the aim of increasing donation rates. DESIGN: This cross-sectional study used a designed self-administered questionnaire. Data were subsequently analysed using IBM SPSS software. SETTING: The study encompassed all 12 cities located in Jordan. PARTICIPANTS: Data were collected from 1146 Jordanian participants, excluding individuals under the age of 18. RESULTS: Approximately 36.6% reported organ or blood donation while 18.9% participated in awareness campaigns. Many (75.7%) perceived insufficient awareness about the importance of organ donation, and 67.1% noted a scarcity of online donor registration platforms. Only 12.0% of participants discussed organ donation with healthcare providers. As anticipated, only 9.0% were registered donors while 67.7% expressed acceptance of organ donation, with 55.3% willing to enrol in donor programmes. Religion influenced 54.2% of organ donation decisions. There are associations between agreement for a new enactment and prior organ or blood donation or discussions with healthcare providers. However, religion affected willingness to donate organs. Most importantly, refusal to be a donor after death was associated with religion, occupation and awareness levels. CONCLUSION: Despite the population's understanding and support for the concept of organ donation, the willingness towards donating their own organs is limited. To boost organ donation rates and acceptance of the new enactment, we recommend conducting educational campaigns, improving online registration platforms, enhancing healthcare provider engagement, collaborating with religious communities and advocating for supportive policies.
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Conocimientos, Actitudes y Práctica en Salud , Obtención de Tejidos y Órganos , Humanos , Estudios Transversales , Jordania , Femenino , Masculino , Adulto , Persona de Mediana Edad , Encuestas y Cuestionarios , Adulto Joven , Donantes de Tejidos/psicología , Adolescente , AncianoRESUMEN
Background: We described the oral nirmatrelvir/ritonavir (NMV/r) and molnupiravir (MOV) uptake among a subgroup of highly vaccinated adults in a US national prospective cohort who were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between 12/2021 and 10/2022. Methods: We estimate antiviral uptake within 5 days of SARS-CoV-2 infection, as well as age- and gender-adjusted antiviral uptake prevalence ratios by antiviral eligibility (based on age and comorbidities), sociodemographic characteristics, and clinical characteristics including vaccination status and history of long coronavirus disease 2019 (COVID). Results: NMV/r uptake was 13.6% (95% CI, 11.9%-15.2%) among 1594 participants, and MOV uptake was 1.4% (95% CI, 0.8%-2.1%) among 1398 participants. NMV/r uptake increased over time (1.9%; 95% CI, 1.0%-2.9%; between 12/2021 and 3/2022; 16.5%; 95% CI, 13.0%-20.0%; between 4/2022 and 7/2022; and 25.3%; 95% CI, 21.6%-29.0%; between 8/2022 and 10/2022). Participants age ≥65 and those who had comorbidities for severe COVID-19 had higher NMV/r uptake. There was lower NMV/r uptake among non-Hispanic Black participants (7.2%; 95% CI, 2.4%-12.0%; relative to other racial/ethnic groups) and among individuals in the lowest income groups (10.6%; 95% CI, 7.3%-13.8%; relative to higher income groups). Among a subset of 278 participants with SARS-CoV-2 infection after 12/2021 who also had a history of prior SARS-CoV-2 infection, those with (vs without) a history of long COVID reported greater NMV/r uptake (22.0% vs 7.9%; P = .001). Among those prescribed NMV/r (n = 216), 137 (63%; 95% CI, 57%-70%) reported that NMV/r was helpful for reducing COVID-19 symptoms. Conclusions: Despite proven effectiveness against severe outcomes, COVID-19 antiviral uptake remains low among those with SARS-CoV-2 infection in the United States. Further outreach to providers and patients to improve awareness of COVID-19 oral antivirals and indications is needed.
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Introduction Overcrowding in emergency departments (EDs) is still a national and international issue. Among the variables contributing to this crisis are an increase in patient numbers and the severity of sickness. One significant issue that has not yet been addressed and is burdening healthcare facilities is the use of EDs by parents of children who have mild illnesses. Developing successful interventions requires an understanding of the factors that lead to nonurgent visits to pediatric EDs (PEDs). Our objective was to assess the variables that could influence parental visits to PEDs. Methodology In the Eastern Region of Saudi Arabia, between September and November 2023, a descriptive cross-sectional survey was conducted among parents who had previously visited a PED. The survey had 21 questions. Along with parental viewpoints and healthcare utilization, parents' evaluations of their child's emergency state were investigated. In addition to gathering and evaluating demographic data, the survey evaluated respondents' impressions of the severity of a disease or injury. Results A total of 776 participants were included in the study. The mean parental age was 32.1 ± 12.7 years, and approximately 32.1% of the participants' children were between the ages of 1 and 5. Nearly half of the children, 44.7%, visited the ED during the evening shift. The most common reasons for presenting were fever (50.5%) and upper respiratory tract symptoms (37.1%). Among these visits, parents perceived 48.5% as nonurgent and 30.2% as urgent. The majority of respondents (54.9%) had received advice before going to the ED. In most cases (47.9%), this was from a relative or a healthcare provider (16.7%). Conclusion This analysis identified some of the reasons parents bring their children to the ED for mild illnesses. The results emphasized the varied nature of the problem. Understanding the reasons for parental ED visits may help us better design targeted interventions to decrease unnecessary visits and lessen the burden on healthcare systems.
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This work examines the cooperative effect between Zr doping and oxygen vacancy engineering in anodized TiO2 nanotubes (TNTs) for enhanced oxygen reduction reactions (ORRs). Zr dopant and annealing conditions significantly affected the electrocatalytic characteristics of grown TNTs. Zr doping results in Zr4+ substituted for Ti4+ species, which indirectly creates oxygen vacancy donors that enhance charge transfer kinetics and reduce carrier recombination in TNT bulk. Moreover, oxygen vacancies promote the creation of unsaturated Ti3+(Zr3+) sites at the surface, which also boosts the ORR interfacial process. Annealing at reductive atmospheres (e.g., H2, vacuum) resulted in a larger increase in oxygen vacancies, which greatly enhanced the ORR activity. In comparison to bare TNTs, Zr doping and vacuum treatment (Zr:TNT-Vac) significantly improved the conductivity and activity of ORRs in alkaline media. The finding also provides selective hydrogen peroxide production by the electrochemical reduction of oxygen.
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Finger stiffness may arise from injuries, surgeries, or hand-related medical conditions, impacting hand function and overall well-being in daily life. Rehabilitation and hand therapy play a crucial role in restoring optimal range of motion, strength, and functionality. This article introduces the Self-Assisted Finger Stiffness Splint (SFSS), a dynamic splint designed for active finger movement applicable in post-trauma or postoperative rehabilitation. SFSS empowers patients to perform self-administered stretching exercises, expediting recovery and improving compliance. Its versatility extends to postoperative rehabilitation, covering cases like tenolysis of extensor tendons or rehabilitation after fracture healing. While particularly effective for proximal interphalangeal joint (PIPJ) and metacarpophalangeal joint (MCPJ) stiffness, SFSS remains valuable for managing isolated finger stiffness and proves beneficial in addressing multiple-digit stiffness.
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Twin reversed arterial perfusion (TRAP) sequence is a rare pregnancy complication occurs in an identical twin pregnancy that share a single placenta. TRAP sequence is a twin's pregnancy includes a normal-developed viable pump fetus and an abnormal usually nonviable acardiac fetus. The nonviable acardiac fetus depends on the pump fetus for his blood supply and put the pump fetus at risk of high cardiac output heart failure and congenital anomalies with high mortality rate. Gray-scale ultrasound and color and pulsed Doppler imaging is a noninvasive accessible imaging modality for the diagnosis of TRAP sequence. Early diagnosis of such conditions is mandatory in order to apply the proper therapeutic measures and to help the normal developed pump fetus to survive. The main goal of management is to interrupt blood supply to the nonviable acardiac fetus to reduce the strain on the heart of the pump fetus thus, increase the chance of survival.
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BACKGROUND: The presence of perinatal asphyxia and its severity appear to correlate with increasing incidence of Acute kidney injury (AKI). The objective of this study is to determine the frequency of AKI and its outcome in birth asphyxia. METHODS: This cross-sectional study was carried out in the Department of Pediatric Medicine from March 2019 to September 2019. A total of 111 newborns with birth asphyxia of gestational age 37-41 weeks were included. Neonates born to mothers having hypertension and diabetes mellitus, patients with congenital kidney anomalies like polycystic kidney disease and renal agenesis, and mothers taking nephrotoxic drugs or any other known cause of AKI like hypovolemic shock were excluded. Urine output (UOP) and final outcome of the patient were also noted. AKI was noted. RESULTS: The mean gestational age was 38.29 ± 1.07 weeks. The mean weight of neonates was 3.08 ± 0.31 kg. The frequency of AKI in birth asphyxia was 20 (18.02%) neonates. Complete recovery in AKI patients was seen in 07 (35.0%) and death in 13 (65.0%) patients. CONCLUSION: This study has shown that the frequency of AKI in birth asphyxia was found in 18.02% neonates with complete recovery seen in 35.0% and death in 65.0% patients.
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Dental resin composites are widely used restorative materials in dentistry for the treatment of carious and non-carious lesions as well as pit and fissure sealants, cavity liners, and endodontic sealers. They consist of two parts: an organic resin matrix and an inorganic/organic filler. The organic resin matrix phase is made up of multifunctional monomers and light-sensitive initiators, while the inorganic/organic filler phase is made up of micro/nano-sized fillers that primarily serve as reinforcement. Despite being a very promising dental material, its monomeric component has some drawbacks. It is well known for leaching out during incomplete polymerization, which can result in cytotoxicity. Bis-GMA (bisphenol A-glycidyl methacrylate) is the most cytotoxic of all monomeric components that exhibit synthetic estrogenic effects. The purpose of this article is to assess the cytotoxic effects of dental composite, understand the possible mechanism behind them, and explore ways to screen for and reduce this harmful effect, as well as shed light on its future prospects.
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A synergistic effect of Co-doping and vacuum-annealing on electrochemical redox reactions of iron oxide films is demonstrated in the present work. In this research, a series of defect-rich iron oxy/hydroxide nanorod arrays: α-FeOOH, Fe2O3, and FeOx nanorod thin film catalysts were synthesized via a hydrothermal approach followed by thermal and vacuum treatments. Besides, a cobalt doping process was employed to prepare the thin film of Co-doped FeOx nanorods. The morphology, crystallinity, and electrochemical activities of Co-doped oxygen-deficient FeOx (Co-FeOx/FTO) show strong correlations with metal concentration and thermal treatments. The electrochemical measurements demonstrated that the as-deposited Co-doped FeOx NR catalyst could achieve a maximum OER current of 30 mA cm-2, which was six times greater than that recorded by as-deposited Co-doped FeOOH NR catalysts (5.7 mA cm-2) at 1.65 V vs. RHE, confirming the superior electrocatalytic OER activity at the as-deposited Co-doped FeOx NR catalyst after cobalt doping. It is believed that these results are attributed to two factors: the synergistic effect of Co doping and the defect-rich nature of FeOx nanorod catalysts that are used in sustainable energy systems.
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Introduction The debonding of acrylic teeth from the denture base, particularly in cases of prominent ridges, is a common problem faced by clinicians and patients. The present study was conducted to assess the effects of various chemical treatments on the shear bond strength (SBS) of acrylic teeth bonded to different high-impact denture base materials. Materials and methods The present in vitro study was conducted on 80 wax specimens with acrylic teeth bonded to two high-impact denture base materials (DPI Tuff (DPI Dental Products of India Ltd, Mumbai) and Trevalon HI (Trevalon HI, Dentsply, Karnataka)). The two main groups were further divided into four subgroups of 10 specimens each, depending on the chemical treatment at the ridge lap area of the tooth: control group without any chemical treatment, chemical surface treatment (CST) with dichloromethane and monomer mix, CST with ethyl acetate, and CST with acrylic adhesive cyanoacrylate. The SBS was tested using a universal testing machine (UTM). Analysis of variance (ANOVA) and post-hoc Tukey tests were used for statistical analyses. Results The mean SBS of Group A (DPI Tuff) was 111.75 N as compared to 118 N in Group B (Trevalon HI). The differences were statistically significant (p<0.05). ANOVA and post-hoc Tukey's tests revealed significant differences between subgroups. The highest mean SBS was noted with a dichloromethane and monomer mix (1:1 volume), followed by the ethyl acetate, control, and cyanoacrylate subgroups. Conclusion The cross-linked acrylic teeth treated with a dichloromethane and monomer mixture (1:1 by volume), processed with Trevalon HI high-impact denture base resin had the highest SBS and thus were indicated for bonding teeth with the suggested denture base.
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BACKGROUND: Routine case surveillance data for SARS-CoV-2 are incomplete, unrepresentative, missing key variables of interest, and may be increasingly unreliable for timely surge detection and understanding the true burden of infection. METHODS: We conducted a cross-sectional survey of a representative sample of 1030 New York City (NYC) adult residents ≥18 years on May 7-8, 2022. We estimated the prevalence of SARS-CoV-2 infection during the preceding 14-day period. Respondents were asked about SARS-CoV-2 testing, testing outcomes, COVID-like symptoms, and contact with SARS-CoV-2 cases. SARS-CoV-2 prevalence estimates were age- and sex-adjusted to the 2020 U.S. POPULATION: We triangulated survey-based prevalence estimates with contemporaneous official SARS-CoV-2 counts of cases, hospitalizations, and deaths, as well as SARS-CoV-2 wastewater concentrations. RESULTS: We show that 22.1% (95% CI 17.9-26.2%) of respondents had SARS-CoV-2 infection during the two-week study period, corresponding to ~1.5 million adults (95% CI 1.3-1.8 million). The official SARS-CoV-2 case count during the study period is 51,218. Prevalence is estimated at 36.6% (95% CI 28.3-45.8%) among individuals with co-morbidities, 13.7% (95% CI 10.4-17.9%) among those 65+ years, and 15.3% (95% CI 9.6-23.5%) among unvaccinated persons. Among individuals with a SARS-CoV-2 infection, hybrid immunity (history of both vaccination and infection) is 66.2% (95% CI 55.7-76.7%), 44.1% (95% CI 33.0-55.1%) were aware of the antiviral nirmatrelvir/ritonavir, and 15.1% (95% CI 7.1-23.1%) reported receiving it. Hospitalizations, deaths and SARS-CoV-2 virus concentrations in wastewater remained well below that during the BA.1 surge. CONCLUSIONS: Our findings suggest that the true magnitude of NYC's BA.2/BA.2.12.1 surge may have been vastly underestimated by routine case counts and wastewater surveillance. Hybrid immunity, bolstered by the recent BA.1 surge, likely limited the severity of the BA.2/BA.2.12.1 surge.
It is difficult to assess the true prevalence of SARS-CoV-2, the virus that causes COVID-19, due to changes in testing practices and behaviors, including increasing at-home testing and decreasing healthcare provider-based testing. We conducted a population-representative survey in New York City to estimate the prevalence of SARS-CoV-2 during the second Omicron surge in spring 2022. We compared survey-based SARS-CoV-2 prevalence estimates with data on diagnosed cases, hospitalizations, deaths, and SARS-CoV-2 concentration in wastewater. Our survey-based estimates were nearly 30 times higher than official case counts and estimates of immunity among those with active infection were high. Taken together, our results suggest that the magnitude of the second Omicron surge was likely significantly underestimated, and high levels of immunity likely prevented a major surge in hospitalizations/deaths. Our findings might inform future work on COVID-19 surveillance and how to mitigate its spread.
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Due to changes in SARS-CoV-2 testing practices, passive case-based surveillance may be an increasingly unreliable indicator for monitoring the burden of SARS-CoV-2, especially during surges. We conducted a cross-sectional survey of a population-representative sample of 3042 U.S. adults between June 30 and July 2, 2022, during the Omicron BA.4/BA.5 surge. Respondents were asked about SARS-CoV-2 testing and outcomes, COVID-like symptoms, contact with cases, and experience with prolonged COVID-19 symptoms following prior infection. We estimated the weighted age and sex-standardized SARS-CoV-2 prevalence, during the 14-day period preceding the interview. We estimated age and gender adjusted prevalence ratios (aPR) for current SARS-CoV-2 infection using a log-binomial regression model. An estimated 17.3% (95% CI 14.9, 19.8) of respondents had SARS-CoV-2 infection during the two-week study period-equating to 44 million cases as compared to 1.8 million per the CDC during the same time period. SARS-CoV-2 prevalence was higher among those 18-24 years old (aPR 2.2, 95% CI 1.8, 2.7) and among non-Hispanic Black (aPR 1.7, 95% CI 1.4,2.2) and Hispanic adults (aPR 2.4, 95% CI 2.0, 2.9). SARS-CoV-2 prevalence was also higher among those with lower income (aPR 1.9, 95% CI 1.5, 2.3), lower education (aPR 3.7 95% CI 3.0,4.7), and those with comorbidities (aPR 1.6, 95% CI 1.4, 2.0). An estimated 21.5% (95% CI 18.2, 24.7) of respondents with a SARS-CoV-2 infection >4 weeks prior reported long COVID symptoms. The inequitable distribution of SARS-CoV-2 prevalence during the BA.4/BA.5 surge will likely drive inequities in the future burden of long COVID.
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COVID-19 , Adulto , Humanos , Adolescente , Adulto Joven , COVID-19/epidemiología , Síndrome Post Agudo de COVID-19 , Prueba de COVID-19 , Estudios Transversales , Prevalencia , SARS-CoV-2RESUMEN
BACKGROUND: We estimated the prevalence of long COVID and impact on daily living among a representative sample of adults in the United States. METHODS: We conducted a population-representative survey, 30 June-2 July 2022, of a random sample of 3042 US adults aged 18 years or older and weighted to the 2020 US population. Using questions developed by the UK's Office of National Statistics, we estimated the prevalence of long COVID, by sociodemographics, adjusting for gender and age. RESULTS: An estimated 7.3% (95% confidence interval: 6.1-8.5%) of all respondents reported long COVID, corresponding to approximately 18 828 696 adults. One-quarter (25.3% [18.2-32.4%]) of respondents with long COVID reported their day-to-day activities were impacted "a lot" and 28.9% had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection more than 12 months ago. The prevalence of long COVID was higher among respondents who were female (adjusted prevalence ratio [aPR]: 1.84 [1.40-2.42]), had comorbidities (aPR: 1.55 [1.19-2.00]), or were not (vs were) boosted (aPR: 1.67 [1.19-2.34]) or not vaccinated (vs boosted) (aPR: 1.41 [1.05-1.91]). CONCLUSIONS: We observed a high burden of long COVID, substantial variability in prevalence of SARS-CoV-2, and risk factors unique from SARS-CoV-2 risk, suggesting areas for future research. Population-based surveys are an important surveillance tool and supplement to ongoing efforts to monitor long COVID.
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COVID-19 , SARS-CoV-2 , Adulto , Humanos , Femenino , Estados Unidos/epidemiología , Masculino , COVID-19/epidemiología , Síndrome Post Agudo de COVID-19 , Factores de Riesgo , Estudios LongitudinalesRESUMEN
In a population-based survey of adults in New York City, we assessed positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests (including via exclusive at-home testing) and possible cases among untested respondents. An estimated 27.4% (95% confidence interval [CI]: 22.8%-32.0%) or 1.8 million adults (95% CI: 1.6-2.1 million) had SARS-CoV-2 infection between 1 January and 16 March 2022.
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COVID-19 , SARS-CoV-2 , Adulto , Humanos , Ciudad de Nueva York/epidemiología , Prevalencia , COVID-19/epidemiologíaRESUMEN
BACKGROUND: This study aimed to compare spheno-occipital synchondrosis (SOS) maturation stages with a three-dimensional assessment of mandibular growth. METHODS: This is a cross-sectional study of a retrospective type, in which cone-beam computed tomography (CBCT) images of 500 patients aged 6 to 25 years (226 males and 274 females) were analyzed. The SOS was evaluated using the four-stage scoring system; completely open, partially fused, semi-fused, or completely fused. The SOS scoring and three-dimensional cephalometric measurements were analyzed by Invivo 6.0.3 software. Descriptive and analytical statistics were performed, and a P-value < 0.05 was considered statistically significant. RESULTS: There was a statistically significant difference in mandibular measurements among SOS maturation stages in both sexes (P < 0.05). The skeletal growth increments of mandibular variables across the SOS stages had higher mean differences between SOS stages 2 and 3 than those between stages 1 and 2 and stages 3 and 4 in both sexes. The mandibular growth curves increased with chronological age (earlier in females) and SOS maturation stages (mostly in stages 1, 2, and 3 than stage 4). CONCLUSIONS: The SOS maturation stages are valid and reliable mandibular skeletal indicators as evaluated with three-dimensional cephalometric mandibular measurements. The findings of growth increments and constructed growth curves of mandibular growth might be helpful in diagnosis and treatment planning.
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Hueso Occipital , Hueso Esfenoides , Masculino , Femenino , Humanos , Hueso Occipital/diagnóstico por imagen , Hueso Esfenoides/diagnóstico por imagen , Estudios Retrospectivos , Estudios Transversales , Mandíbula/diagnóstico por imagen , Tomografía Computarizada de Haz Cónico/métodosRESUMEN
BACKGROUND: Passive, case-based surveillance underestimates the true extent of active infections in the population due to undiagnosed and untested cases, the exclusion of probable cases diagnosed point-of-care rapid antigen tests, and the exclusive use of at-home rapid tests which are not reported as part of case-based surveillance. The extent in which COVID-19 surveillance may be underestimating the burden of infection is likely due to time-varying factors such as decreased test-seeking behaviors and increased access to and availability of at-home testing. OBJECTIVE: The objective of this study is to estimate the prevalence of SARS-CoV-2 based on different definitions of a case to ascertain the extent to which cases of SARS-CoV-2 may be underestimated by case-based surveillance. METHODS: A survey on COVID-19 exposure, infection, and testing was administered to calculate point prevalence of SARS-CoV-2 among a diverse sample of cohort adults from February 8, 2022, to February 22, 2022. Three-point prevalence estimates were calculated among the cohort, as follows: (1) proportion positives based on polymerase chain reaction (PCR) and rapid antigen tests; (2) proportion positives based on testing exclusively with rapid at-home tests; and (3) proportion of probable undiagnosed cases. Test positivity and prevalence differences across booster status were also examined. RESULTS: Among a cohort of 4328, there were a total of 644 (14.9%) cases. The point prevalence estimate based on PCR or rapid antigen tests was 5.5% (95% CI 4.8%-6.2%), 3.7% (95% CI 3.1%-4.2%) based on at-home rapid tests, and 5.7% (95% CI 5.0%-6.4%) based on the case definition of a probable case. The total point prevalence across all definitions was 14.9% (95% CI 13.8%-16.0%). The percent positivity among PCR or rapid tests was 50.2%. No statistically significant differences were observed in prevalence between participants with a COVID-19 booster compared to fully vaccinated and nonboosted participants except among exclusive at-home rapid testers. CONCLUSIONS: Our findings suggest a substantial number of cases were missed by case-based surveillance systems during the Omicron B.1.1.529 surge, when at-home testing was common. Point prevalence surveys may be a rapid tool to be used to understand SARS-CoV-2 prevalence and would be especially important during case surges to measure the scope and spread of active infections in the population.
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COVID-19 , SARS-CoV-2 , Adulto , Humanos , COVID-19/diagnóstico , COVID-19/epidemiología , Prevalencia , Prueba de COVID-19 , Encuestas y CuestionariosRESUMEN
Background: Global polio eradication is a goal yet to be achieved in countries like Pakistan. In recent years, the Polio Eradication Initiative has been making steady progress with good campaign coverage and low numbers of polio cases. However, in 2019 Pakistan reported 146 cases compared to 12 in 2018. A major factor cited for this regression was a surge in vaccine refusals by parents and caretakers. Aims: To assess the reasons for the refusal of polio vaccination in Quetta Block, Balochistan. Methods: The study was conducted using data acquired from 2 polio vaccination campaigns over 3 months in 2019. The data were collected in Quetta Block, a highly endemic zone having continuous transmission of the polio virus over several years. The data were analysed using the statistical software, SPSS, version 20. We used descriptive statistics to demon-strate the characteristics of the study population. Categorical variables were measured as frequencies and percent ages. Results: Refusal rates were almost 8.6% for the polio campaign of April and 8.1% for June 2019. Misconceptions about vaccines made up 56.4% of reasons for refusals, followed by religion 16%. Conclusion: Misconceptions about the vaccine are the main driving force behind vaccine refusals in the study setting. Efficient strategies are required to address misconceptions in this red zone of poliovirus transmission in Balochistan.
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Enfermedades Transmisibles , Pakistán , PoliomielitisRESUMEN
The oxidative desulfurization (ODS) of dibenzothiophene in diesel fuel cut using a homogeneous liquid catalytic system in a novel reactor is presented. Hydrogen peroxide was the oxidizing agent and acetic acid was the liquid catalyst. The oxidation process was conducted in a meso-oscillatory baffled reactor ("mesoOBR") under mild operating conditions: atmospheric pressure, and 60 to 80 °C. The reactor was operated over a range of residence times (1-3 min), and frequencies and amplitudes of oscillation, leading to oscillatory Reynolds numbers in the range 64-383, and net flow Reynolds numbers in the range 5 to 16. The results showed that dibenzothiophene (DBT) removal in the OBR was significantly higher than in conventional processes under the same conditions (pressure of 1 atm and temperature near room temperature). The maximum DBT conversion was 94%, which was achieved in 3 min at 4 Hz and 6 mm amplitude. A significant improvement in the removal efficiency of DBT was achieved in OBR within only 3 minutes compared to previous studies, which required at least a half-hour reaction time to achieve the same or less removal efficiency. A reaction kinetic model was developed using the optimum experimental results achieved in the OBR. The apparent reaction order was 1, with significantly low apparent activation energies (24.7-29.0 kJ mol-1).
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The recent studies evaluated the extensive exploitation of azo dyes as food colorant to improve the texture of food to turn the food to be very attractive. The heavy consumption of the food colorants by the food industries in commonly consumed beverages especially in the soft drinks may become the cause of certain suspected diseases. Amaranth is an azo dye which easily cleaved into amines and is suspected to be mutagen and carcinogen. Thus, the quantification of amaranth through reliable and sensitive sensor is of great importance. The SnO2/rGO nanocomposite has been engineered to be utilized as chemically modified sensor for the low-level quantification of amaranth in soft drinks and water sample. The fabricated nanocomposite materials was characterized through XRD, FTIR, raman and TEM tools which revealed average crystalline size of 23.7 nm, different surface functionalities and internal rectangle shaped morphology. The engineered nanocomposite was electrochemically characterized through electrochemical impedance spectroscopy (EIS) and Tafel plot to evaluate the electrocatalytic properties and charger transfer kinetics of SnO2/rGO/Nafion/GCE. The resistance of bare, GO/GCE and SnO2/rGO/Nafion/GCE was calculated as 812.5 Ω, 1343 Ω and 338 Ω. Certain parameters were optimized such as PBS electrolyte pH 6, scan rate 130 mV/s and potential window (0.4-1.2 V) to carry out sensitive and fluent determination process of amaranth azo dye. For the effectiveness of proposed sensor two calibration ranges were optimized from 1 to 800 nM and 1-60 µM. The LOD for both ranges were calculated as 0.68 nM and 0.0027 µM. Moreover, the anti-interference and stability profile of developed sensor were found phenomenal that suggest the exceptional electrocatalytic performance of SnO2/rGO/Nafion/GCE for amaranth.