Understanding Racial Attitudes Among Students and Teachers in a Ethnically/Racially Diverse High School.

This study examined the role of racial attitudes in a diverse high school setting. Teachers and students were recruited from a public charter high school in Albuquerque, New Mexico. The final sample consisted of 19 students and 10 teachers who participated in face-to-face interviews regarding racial attitudes and racial bias in the academic setting. Three themes emerged among the teacher interviews: rejecting racial inequalities, contradicting thoughts and color-blind explanations, and racially conscious explanations. For the student interviews, two themes emerged: color-blind racial attitudes and witnessing/experiencing bias. These findings yield evidence that color-blind racial attitudes are prevalent in diverse schools among students and teachers, presenting a challenge to intervention efforts in schools aimed at promoting racial justice.

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity.

Obesity is an established risk factor for cancer in many tissues. In the mammalian intestine, a pro-obesity high-fat diet (HFD) promotes regeneration and tumorigenesis by enhancing intestinal stem cell (ISC) numbers, proliferation, and function. Although PPAR (peroxisome proliferator-activated receptor) nuclear receptor activity has been proposed to facilitate these effects, their exact role is unclear. Here we find that, in loss-of-function in vivo models, PPARα and PPARδ contribute to the HFD response in ISCs. Mechanistically, both PPARs do so by robustly inducing a downstream fatty acid oxidation (FAO) metabolic program. Pharmacologic and genetic disruption of CPT1A (the rate-controlling enzyme of mitochondrial FAO) blunts the HFD phenotype in ISCs. Furthermore, inhibition of CPT1A dampens the pro-tumorigenic consequences of a HFD on early tumor incidence and progression. These findings demonstrate that inhibition of a HFD-activated FAO program creates a therapeutic opportunity to counter the effects of a HFD on ISCs and intestinal tumorigenesis.