1.
Bioorg Med Chem Lett
; 19(3): 654-7, 2009 Feb 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19121939
RESUMEN
It is believed that beta-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify beta-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for beta-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed.