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1.
Front Psychol ; 15: 1197975, 2024.
Article En | MEDLINE | ID: mdl-38741759

According to the literature, religious commitment could be a protective factor against dangerous behaviors, such as criminal offending, unsafe sex, and substance use. Our study aims to investigate the influence of Family Religiosity and climate on anger dysregulation and deviance propensity in a sample of 214 justice-involved boys from Italian Youth Detention Centers (range 14-25). The sample was divided into religious (n = 102) and non-religious (n = 112) justice-involved juveniles. Participants filled in the following questionnaires: Deviant Behavior Questionnaire, Aggression Questionnaire, Family Communication Scale, Moral Disengagement Scale, and the Multidimensional Scale of Perceived Social Support. We used a partial least square structural equation modeling (PLS_SEM) method to build our model and we found that Family Religiosity was positively associated with Family Climate which was negatively associated with Anger Dysregulation and Deviance Propensity, and Anger Dysregulation was positively related to Deviance Propensity. The multigroup analysis confirmed that for justice-involved juveniles who interiorized religious discipline and beliefs, Family Religiosity showed a positive association with Family Climate, which had a negative relationship with Anger Dysregulation, which strongly predicted Deviance Propensity. This result could be useful to promote new development goals and preventive activities and interventions based on positive religiosity values in juveniles' behavior.

2.
Behav Sci (Basel) ; 14(4)2024 Apr 04.
Article En | MEDLINE | ID: mdl-38667094

The literature has linked childhood emotional abuse (CEA) to severe negative outcomes such as the development of several maladaptive personality traits and coping mechanisms. Nonetheless, its concurrent connection with neuroticism, perfectionism, and workaholism has not been explored. For the above reasons, the present study sought to investigate whether neuroticism and perfectionism mediate the relationship between CEA and workaholism, as well as evaluate the gender invariance of the model. The sample of the present research comprised 1176 young workers (50% women), aged 18-25, who completed validated self-report questionnaires. The findings highlighted significant positive direct and indirect paths, suggesting a complex interplay between CEA, neuroticism, perfectionism, and workaholism. Furthermore, the model exhibited no significant differences between genders, suggesting that the identified relationships are consistent across both women and men. The findings highlight the importance of identifying CEA and considering the adoption of trauma-informed approaches to manage its adverse effects, thereby potentially averting the onset of workaholism. Moreover, the results underline the necessity for customized preventive measures, aiming to mitigate traits associated with neuroticism and perfectionism as potential paths for successful therapeutic interventions.

3.
Int J Psychol ; 59(3): 450-459, 2024 Jun.
Article En | MEDLINE | ID: mdl-38282423

There is clear evidence linking trauma, mindfulness, dissociation and problematic internet use (PIU). Nonetheless, little is known about the role trait mindfulness and dissociative experiences may have in the relationship between childhood emotional abuse (CEA) and PIU, as well as the role that gender may have in such relationships. In the current research, self-report questionnaires on CEA, trait mindfulness, dissociative experiences and PIU were administered to 1074 Italian adolescents (50% females) aged 14-17 years old, to test whether trait mindfulness and dissociative experiences mediated the relationship between CEA and PIU, and whether the proposed mediation was invariant across genders. Furthermore, the main analyses were controlled for background variables. The findings highlighted significant associations between all direct and indirect paths and invariance of the mediation model across boys and girls. The results of this study highlight that emotionally abused boys and girls with high levels of dissociation and inadequate mindful skills may be more exposed to dysfunctional online activities. Hence, developing dissociation-focused and mindfulness-based interventions for emotionally abused adolescents may be clinically effective when building tailored approaches for the prevention and management of PIU. Further implications are discussed.


Dissociative Disorders , Internet Addiction Disorder , Mindfulness , Humans , Adolescent , Male , Female , Italy , Dissociative Disorders/psychology , Internet Addiction Disorder/psychology , Child Abuse/psychology , Emotional Abuse/psychology , Emotional Abuse/statistics & numerical data , Sex Factors , Surveys and Questionnaires
4.
Healthcare (Basel) ; 11(11)2023 May 29.
Article En | MEDLINE | ID: mdl-37297726

OBJECTIVE: The research aims to investigate family communication regarding sexuality and the possible link between insecure attachment, violence in relationships, and the tendency toward sexual sensation-seeking in a sample of Italian sexual offenders. DESIGN AND METHOD: We evaluated 29 male sexual offenders in two correctional facilities of Southern Lazio (Italy) (mean age = 40.76; SD = 11.16). The participants completed general questions about their family and sexual education and fulfilled the following questionnaires: Compulsive Sexual Behavior Inventory (CSBI), Sexual Sensation-seeking Scale (SSSS), and the High-Risk Situation Checklist, adapted in Italian, as well as the Attachment Style Questionnaire (ASQ), validated in Italian. RESULTS: Most of the participants had never talked about sex within their family and perceived a severe or abusive education during childhood. In addition, positive correlations emerged between SSSS and the two scales of the CSBI, as well as between insecure attachment style, CSBI, and sexual sensation-seeking. The participants also reported some critical issues regarding the personal perception of high-risk situations linked to sexual relapse. CONCLUSIONS: The data suggest factors to investigate, such as family education and relationships and the personal perception of sexual recidivism. The results might be effective in treatment and prevention programs among sex offenders.

5.
Psychol Health Med ; 28(7): 1818-1830, 2023.
Article En | MEDLINE | ID: mdl-36747368

Past findings highlighted the presence of distress symptoms and poor quality of life in people with endometriosis. Several studies showed that trait Emotional Intelligence (trait EI) is a key component of one's wellbeing, whilst Illness Perceptions may play an important role in psychological distress and perceived quality of life. The current study sought to test the hypothesis that an association between trait EI and Quality of Life in individuals with endometriosis would be mediated by Illness Perceptions, examining also the relations with General Distress (depression, anxiety, and stress). 364 women with endometriosis aged between 18 and 58 years old (M = 33.87; SD = 8.64) filled a protocol to assess Trait EI, Illness Perceptions, General Distress, and Quality of Life. Structural Equation Modelling was used to assess the relationship between the observed variables. Illness Perception was a mediator in the relationship between Trait EI, General Distress, and Quality of Life. Moreover, General Distress was a mediator between Trait EI and Quality of Life, and between Illness Perceptions and Quality of Life. Results showed that both Trait EI and Illness perceptions are key components for levels of distress and quality of life in women with endometriosis.


Endometriosis , Quality of Life , Humans , Female , Adolescent , Young Adult , Adult , Middle Aged , Quality of Life/psychology , Anxiety/psychology , Anxiety Disorders , Emotional Intelligence
6.
Psychol Russ ; 16(4): 3-20, 2023.
Article En | MEDLINE | ID: mdl-38162809

Background: The phenomenon of sexting consists of sending and sharing sexual images, videos, or messages using smartphones and social networks. Sexting is spreading dangerously among adolescents who share private and explicit sexual content, ignoring the negative and risky consequences associated with this behavior. According to recent literature, sexting behavior is strongly related to the participants' level of self-esteem and social media's influence on them. Objective: Our study was a descriptive community-based study focused on the central-south Italian context, which aimed to investigate sexually risky behavior and the main motivations for sexting, and to compare differences in self-esteem and social media's influence among three groups of Italian girls: non-sexters, occasional sexters, and frequent sexters. Design: Our research involved 569 Italian girls (14-19 years old) who completed the following questionnaires: the Health and Sexual Behavior Questionnaire; the Sexting Behavior Scale; the Multidimensional Self-Concept Scale; and the Sociocultural Attitudes Toward Appearance Questionnaire-3. Results: Our results showed that most participants sexted with their partner, and had a responsible attitude toward sexuality and kept sexual risk low. Moreover, frequent sexters had higher scores on social media's influence relative to the internalization of the body image and model for beauty and athleticism, as well as lower levels of global, academic, and competence self-esteem. Conclusion: Our results could promote interventions in the school context in order to: a) improve awareness among youth about social media use, sexting, and safe sexuality; b) reduce the risk associated with sexting and the influence of social networks; and c) stimulate reflections by teachers and parents on adolescents' sense of identity and self-esteem.

7.
Front Sociol ; 7: 1106569, 2022.
Article En | MEDLINE | ID: mdl-36687017
8.
Front Psychol ; 12: 673954, 2021.
Article En | MEDLINE | ID: mdl-34381398

Despite the copiousness of studies on the risky behaviors of adolescents, we cannot establish with certainty the leading aspects involved in teens' substance abuse and criminal actions. This review aims to explore the interplay among the family system, substance abuse, and criminal behavior. An analysis of the main results of the 61 articles published between 2010 and 2020 shows that adolescents whose parents are justice-involved and often absent from home are more likely to perceive lower cohesion, support, and poor family communication. These factors can involve them in criminal acts and substance abuse. Moreover, these conducts are often linked to a form of uneasiness and a search of autonomy. Indeed, risky behaviors could have more than one meaning. Our findings also suggest that the most diffused drug-related crimes in adolescence are economic crimes, weapon carrying, robberies, dealing, and drug possession. Considering these results, future clinical implications might be based on multidimensional approaches, focusing more on the family context to promote interventions for at-risk adolescents.

9.
Front Psychol ; 12: 694212, 2021.
Article En | MEDLINE | ID: mdl-34393924

Empathy is a fundamental construct that allows individuals to perceive and understand the cognitive and emotional state of others. Empathy is not only a psychological and sociological concept; it also heavily impacts our daily lives by affecting our decisions and actions. Empathy is connected to and involves specific parts of the brain which, if damaged or of reduced volume, can lead to actions that are morally unjust, aggressive, or simply denoting a lack of understanding and sensitivity. The literature affirms that the low level of empathy, guilt, embarrassment, and moral reasoning displayed by violent and psychopathic criminals is strongly associated with empathy-linked brain regions that are smaller in size or less developed. The aim of this review is to show empirical data over the last 5 years on the connection between empathy and neuroscience among violent and psychopathic offenders, reflecting on future research on the topic.

10.
Article En | MEDLINE | ID: mdl-34069273

Children and adolescents are too often victims of sexual abuse and harassment. According to the World Health Organization (WHO), approximately 150 million girls and 73 million children <18 have been victims of violence and sexual exploitation during their childhood. Data show that females are more likely to be a victim of abuse and violence than males (20% vs. 5-10%). Such abuses lead to long-term psychophysical and relational consequences and victims are often afraid of asking for support from both parents and professionals. This case report shows the story of a 17-year-old adolescent, Sara, involved by her mother in a strategic counseling process, to solve BDSM-type sexual addiction (slavery and discipline, domination and submission, sadism and masochism), self-aggressive behavior, and alcohol abuse issues. The strategic counseling process is structured in 15 sessions and was based on problem-solving techniques and corrective behavioral strategies. During the sessions, it emerged that Sara had been a victim of sexual violence at the age of 6 and that she had never talked about the rape with anyone. At the age of 12, she began to experience social anxiety and shame, feelings that led her to use alcohol and seek violent sexual partners and bondage relationships. During the counseling sessions, Sara elaborated on her trauma, becoming more aware of her resources and her desires, and she learned to manage the sense of guilt and shame associated with the violence suffered, through alternative strategies. At the end of the process, Sara normalized her relationship with sex and alcohol, regaining her identity.


Sadism , Sex Offenses , Adolescent , Child , Counseling , Female , Humans , Male , Masochism , Sexual Behavior
11.
Front Psychol ; 12: 798260, 2021.
Article En | MEDLINE | ID: mdl-35069392

The COVID-19 pandemic and its related restrictions significantly impacted individuals' health, wellbeing, and security. Isolation, limitation of movement, social distancing, and forced cohabiting have had a strong influence on all areas of people's lives as well as on their sexuality. Investigating how the COVID-19 outbreak and its consequences impacted people's sexuality was the primary aim of this review. Particularly, we focused on: (1) the variables associated with the improvement or the deterioration of individuals' and couples' lives during the pandemic; (2) the use of sex as a coping strategy; (3) the impact of COVID-19 outbreak on LGBT people. Results have shown that the worsening of sexual life seems to be related to couples' conflict, emotions and psychological difficulties, being female, being single or away from the partner, being a health care worker, and having children. Moreover, a detrimental effect on sexuality was associated with stress, forced cohabitation, routine, anxiety and worry about the job and the pandemic, feeling partner distance, being unhappy with their partner, and lack of privacy. On the other hand, improvements in sexuality were associated with living happily with a partner, being happy and satisfied with a partner, feeling less stressed and more bored, having more free time, having fewer recreation opportunities, and having minor workload. During the pandemic, there was an increase in using sex toys, pornography consumption, masturbating, and trying sexual experimentations. Among LGBT people, an increase was found in the number of casual sexual partners potentially due to the perceived lower likelihood of transmission through sex. Moreover, the increase in sexual activity may have represented a coping strategy to quarantine-related distress.

12.
Front Psychiatry ; 12: 795221, 2021.
Article En | MEDLINE | ID: mdl-35126205

The recent COVID-19 pandemic impacted healthcare professionals psychologically. They were unprepared to handle such a powerful and unknown virus. Consequently, they had to face situations of extreme distress, developing vicarious traumatization and post-traumatic stress disorder (PTSD). The first one is associated with the "cost of caring" for others and affected persons who constantly are exposed to other sufferings. PTSD is a psychiatric disorder that could affect people who have experienced or witnessed a traumatic event. Post-traumatic stress disorder (PTSD) and correlated symptoms might impact the lives of healthcare professionals at the personal, professional, and relational levels. Furthermore, the pandemic could decrease the empathy of healthcare professionals, influencing their relationship with patients. This review aimed to describe the incidence of PTSD among HPs during the COVID-19 pandemic. We focused on the following aspects: (a) PTSD symptoms and correlated psychological issues, (b) repercussions at working and personal levels, (c) change in empathetic involvement of healthcare professionals.

13.
Front Psychol ; 11: 607225, 2020.
Article En | MEDLINE | ID: mdl-33324303

Cyberbullying is associated with the expansion of digital devices and the Internet. In Italy and other European and non-European countries, the phenomenon is growing. Young people who suffer from cyberbullying develop psychopathological symptoms of anxiety, depression, and social phobia that can lead to extreme acts, such as suicide. The pressure, the sense of isolation, and helplessness experienced by cyber-victims also affect their family and the school context. Cyberbullying is acted through digital tools, it is often anonymous, and aims to destroy and psychologically humiliate the victim. There are various forms of cyberbullying that involve different reactions and consequences. However, few studies have focused on adolescents' perception of cyberbullying. Youths often engage in aggressive behaviors, ignoring the feelings and reactions of the victims. Based on these considerations, our article aims to provide a general overview of the spread of the phenomenon and to understand the various types of cyberbullying and its consequences on victims. We will also illustrate a brief evaluation conducted in Italian schools investigating the perception of cyberbullying in a sample of 600 Italian adolescents (11-14 years old). Our work aims to investigate the cognition and the personal perception of youths about cyberbullying and its consequences and to promote educational interventions within and outside the context of school.

14.
Article En | MEDLINE | ID: mdl-33322053

Transgressive conduct and opposition towards the rules often characterize adolescence. During the development, antisocial and aggressive behavior could be a way to grow personally and to be independent. According to previous studies results, the family has a high impact on teens' aggressive behaviors and moral disengagement. Our research involved 2328 Italian adolescents (13-19 years old) who have filled in the following questionnaires: deviant behavior questionnaire; aggression questionnaire; family communication scale; moral disengagement scale; the multidimensional scale of perceived social support. Our study investigated the role of family structure on deviance propensity through family climate and anger dysregulation joint influence. We conducted a mediation analysis to reach this goal using structural equation modeling (SEM). We have also conducted a multigroup analysis in order to evaluate gender differences in the SEM. Results showed that both family climate and anger dysregulation mediated the relationship between family structure and deviance propensity. The multigroup analysis revealed that the indirect relationship between variables through family climate is significant for both boys and girls (higher in females); variables indirect relationship through anger dysregulation was significant only for girls. These data could be useful for prevention and intervention programs on children-parent relationships and to reduce antisociality and teenager's aggressive behavior.


Adolescent Behavior , Aggression , Anger , Family Relations , Adolescent , Adolescent Behavior/psychology , Adult , Antisocial Personality Disorder/prevention & control , Family Relations/psychology , Female , Humans , Italy , Male , Motivation , Young Adult
15.
Front Psychol ; 11: 577684, 2020.
Article En | MEDLINE | ID: mdl-33132986

The recent Covid-19 pandemic has had significant psychological and social effects on the population. Research has highlighted the impact on psychological well-being of the most exposed groups, including children, college students, and health workers, who are more likely to develop post-traumatic stress disorder, anxiety, depression, and other symptoms of distress. The social distance and the security measures have affected the relationship among people and their perception of empathy toward others. From this perspective, telepsychology and technological devices assume important roles to decrease the negative effects of the pandemic. These tools present benefits that could improve psychological treatment of patients online, such as the possibility to meet from home or from the workplace, saving money and time and maintaining the relationship between therapists and patients. The aim of this paper is to show empirical data from recent studies on the effect of the pandemic and reflect on possible interventions based on technological tools.

16.
Article En | MEDLINE | ID: mdl-32218258

Sexuality is considered an important aspect of holistic care, but research has shown that it is often not considered, as it should be, in health services. Addressing clients' sexuality requires a multidisciplinary approach and is not the responsibility of a single professional. The literature underlines that university students or those working in hospitals and other health care facilities are not adequately prepared to meet patients' needs regarding sexuality. The objective of this study was, therefore, to review the scientific literature addressing training courses for health professionals in sexuality between 2000 and 2020. Several studies have shown enhancement in health care professionals' ability to deal with patients' sexuality issues after participating in sexuality education programs, regardless of the course load and modality, even if the long-term effects have still to be proved. Health care professionals therefore require education in the area of sexuality, regardless of their discipline. According to the articles reviewed, in order to improve the performance and comfort level of health care professionals to deal with patients' sexuality, investments in training are necessary. Further evaluations of interdisciplinary sexuality education programmes should use larger samples and explore the differences across disciplines.


Health Personnel , Sexual Behavior , Sexuality , Attitude of Health Personnel , Humans
17.
Dig Liver Dis ; 51(10): 1380-1387, 2019 10.
Article En | MEDLINE | ID: mdl-31010743

BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) is the most common endoscopic procedure used to provide nutritional support. AIM: To prospectively evaluate the mortality and complication incidences after PEG insertion or replacement. METHODS: All patients who underwent PEG insertion or replacement were included. Details on patient characteristics, ongoing therapies, comorbidities, and indication for PEG placement/replacement were collected, along with informed consent form signatures. Early and late (30-day) complications and mortality were assessed. RESULTS: 950 patients (47.1% male) were enrolled in 25 centers in Lombardy, a region of Northern Italy. Patient mean age was 73 years. 69.5% of patients had ASA status 3 or 4. First PEG placement was performed in 594 patients. Complication and mortality incidences were 4.8% and 5.2%, respectively. The most frequent complication was infection (50%), followed by bleeding (32.1%), tube dislodgment (14.3%), and buried bumper syndrome (3.6%). At multivariable analysis, age (OR 1.08 per 1-year increase, 95% CI, 1.0-1.16, p = 0.010) and BMI (OR 0.86 per 1-point increase, 95% CI, 0.77-0.96, p = 0.014) were factors associated with mortality. PEG replacement was carried out in 356 patients. Thirty-day mortality was 1.8%, while complications occurred in 1.7% of patients. CONCLUSIONS: Our data confirm that PEG placement is a safe procedure. Mortality was not related to the procedure itself, confirming that careful patient selection is warranted.


Enteral Nutrition/methods , Gastrostomy/adverse effects , Gastrostomy/mortality , Aged , Aged, 80 and over , Comorbidity , Enteral Nutrition/adverse effects , Female , Humans , Italy/epidemiology , Logistic Models , Male , Middle Aged , Multivariate Analysis , Patient Selection , Prospective Studies , Time Factors
18.
J Hepatol ; 70(3): 379-387, 2019 03.
Article En | MEDLINE | ID: mdl-30472321

BACKGROUND AND AIMS: The efficacy and safety of glecaprevir/pibrentasvir (G/P) for patients infected with hepatitis C virus (HCV) have only been investigated in clinical trials, with no real-world data currently available. The aim of our study was to investigate the effectiveness and safety of G/P in a real-world setting. METHODS: All patients with HCV consecutively starting G/P between October 2017 and January 2018 within the NAVIGATORE-Lombardia Network were analyzed. G/P was administered according to drug label (8, 12 or 16 weeks). Fibrosis was staged either histologically or by liver stiffness measurement. Sustained virological response (SVR) was defined as undetectable HCV-RNA 12 weeks after the end of treatment. RESULTS: A total of 723 patients (50% males) were treated with G/P, 89% for 8 weeks. The median age of our cohort was 58 years, with a median body mass index of 23.9 kg/m2, and median liver stiffness measurement of 6.1 kPa; 84% were F0-2 and 16% were interferon-experienced. Median HCV-RNA was 1,102,600 IU/ml, and 49% of patients had HCV genotype 1 (32% 1b), 28% genotype 2, 10% genotype 3 and 13% genotype 4. The median estimated glomerular filtration rate was 90.2 ml/min, platelet count 209x103/mm3 and albumin 4.3 g/dl. The SVR rates were 94% in intention-to-treat and 99.3% in per protocol analysis (8-week vs. 12 or 16-week: 99.2% vs. 100%). Five patients failed therapy because of post-treatment relapse; a post-treatment NS5A resistance-associated substitution was detected in 1 case. SVR rates were lower in males (p = 0.002) and in HCV genotype-3 (p = 0.046) patients treated for 8 weeks, but independent of treatment duration, fibrosis stage, baseline HCV-RNA, HIV co-infection, chronic kidney disease stage and viral kinetics. Mild adverse events were reported in 8.3% of the patients, and 0.7% of them prematurely withdrew treatment. Three patients died of drug-unrelated causes. CONCLUSIONS: In a large real-world cohort of Italian patients, we confirmed the excellent effectiveness and safety of G/P administered for 8, 12 or 16 weeks. LAY SUMMARY: A large number of patients with hepatitis C virus have been treated with glecaprevir/pibrentasvir (G/P) within the NAVIGATORE-Lombardia Network, in Italy. This is the first real-world study evaluating effectiveness and safety of G/P in patients with hepatitis C virus treated according to international recommendations. This study demonstrated excellent effectiveness (with sustained virological response rates of 99.3%) and safety profiles.


Benzimidazoles , Hepatitis C, Chronic , Liver/pathology , Quinoxalines , Sulfonamides , Aminoisobutyric Acids , Antiviral Agents/administration & dosage , Antiviral Agents/adverse effects , Benzimidazoles/administration & dosage , Benzimidazoles/adverse effects , Biopsy/methods , Cohort Studies , Cyclopropanes , Drug Combinations , Elasticity Imaging Techniques/methods , Female , Hepacivirus/drug effects , Hepacivirus/genetics , Hepatitis C, Chronic/complications , Hepatitis C, Chronic/diagnosis , Hepatitis C, Chronic/drug therapy , Hepatitis C, Chronic/epidemiology , Humans , Italy/epidemiology , Lactams, Macrocyclic , Leucine/analogs & derivatives , Liver Cirrhosis/diagnosis , Liver Cirrhosis/etiology , Male , Middle Aged , Proline/analogs & derivatives , Pyrrolidines , Quinoxalines/administration & dosage , Quinoxalines/adverse effects , RNA, Viral/analysis , Sulfonamides/administration & dosage , Sulfonamides/adverse effects , Sustained Virologic Response , Treatment Outcome
19.
Pathol Oncol Res ; 21(3): 535-46, 2015 Jul.
Article En | MEDLINE | ID: mdl-25573591

One-hundred-fourteen consecutive cases of breast ultrasound-guided 14-gauge needle core biopsy (14G NCB) performed from January 2001 to June 2013 and diagnosed as non-malignant papillary lesion (PL)-B3, were reviewed and compared with definitive histological diagnosis on surgical excision (SE) to evaluate the diagnostic accuracy of ultrasound-guided 14G NCB. PL with epithelial atypia on 14G NCB were associated to malignancy on definitive histological diagnosis on SE in 22 (7 DCIS and 15 invasive carcinomas) of 46 cases with an underestimation rate of 47.8 %, while 9 (4 DCIS and 5 invasive carcinomas) cases out of 68 cases of PL without epithelial atypia were upgraded to carcinoma with an underestimation rate of 13.2 %. In cases of PL with epithelial atypia on ultrasound-guided 14G NCB, SE appears mandatory due to the high risk of associated malignancy. The diagnosis of PL without epithelial atypia on ultrasound-guided 14G NCB does not exclude malignancy at subsequent SE, consequently further assessment (by surgical or vacuum-assisted excision) is recommended to avoid the risk of delaying a diagnosis of malignancy, although this tends to be lower (1 in 8 patients).


Breast Diseases/pathology , Breast/pathology , Carcinoma, Ductal, Breast/pathology , Carcinoma, Intraductal, Noninfiltrating/pathology , Carcinoma, Papillary/pathology , Ultrasonography, Interventional , Adult , Aged , Biopsy , Breast Diseases/diagnostic imaging , Breast Diseases/surgery , Carcinoma, Ductal, Breast/diagnostic imaging , Carcinoma, Ductal, Breast/surgery , Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging , Carcinoma, Intraductal, Noninfiltrating/surgery , Carcinoma, Papillary/diagnostic imaging , Carcinoma, Papillary/surgery , Female , Humans , Middle Aged , Neoplasm Staging , Prognosis , Retrospective Studies
20.
Head Neck Pathol ; 9(2): 300-4, 2015 Jun.
Article En | MEDLINE | ID: mdl-25194351

Paragangliomas (PGs) of the head and neck region are typically benign, slow-growing neuroendocrine tumours. At times, they may exhibit unusual histological features, such as prominent stromal sclerosis (sclerosing PG), which may raise concerns of malignancy. We describe a case of sclerosing PG of the carotid body, emphasizing the value of immunohistochemical stains for differential diagnosis. A 43-year-old woman presented with a painless lump on the neck. A magnetic resonance imaging scan demonstrated a hypervascular lesion of the carotid body, which was surgically excised. Grossly, the lesion measured 1.8 cm at maximum diameter. On microscopic examination, irregular nests and tiny bundles of neoplastic cells were found between thick bands of fibrous tissue. Focal nuclear cytomegaly and marked pleomorphism were noted. Neoplastic cells proved to be immunoreactive for chromogranin, synaptophysin and neuron specific enolase, but negative for cytokeratins, smooth muscle actin and CD34. Ultrastructurally, numerous mitochondria, rough endoplasmic reticulum structures and endocrine granules were seen in the cytoplasm of the tumour cells. On consideration of the above-mentioned clinico-pathological and ultrastructural findings a diagnosis of sclerosing PG was established. Sclerosing PG is a rare entity which may mimic a malignant neoplasm. The recognition of this unusual morphological variant of PG, together with appropriate immunostains, leads to the correct diagnosis.


Carotid Body Tumor/diagnosis , Carotid Body Tumor/pathology , Head and Neck Neoplasms/diagnosis , Head and Neck Neoplasms/pathology , Neuroendocrine Tumors/diagnosis , Neuroendocrine Tumors/pathology , Adult , Carotid Body Tumor/metabolism , Chromogranins/metabolism , Diagnosis, Differential , Female , Head and Neck Neoplasms/metabolism , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Neuroendocrine Tumors/metabolism , Phosphopyruvate Hydratase/metabolism , Sclerosis/diagnosis , Sclerosis/metabolism , Sclerosis/pathology , Synaptophysin/metabolism
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