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1.
Rom J Intern Med ; 61(3): 167-174, 2023 Sep 01.
Article En | MEDLINE | ID: mdl-37389671

Carcinomatosis of the bone marrow is a rare clinical condition characterized by diffuse tumor infiltration of the bone marrow accompanied by hematological abnormalities, including thrombotic microangiopathy (TMA) and disseminated intravascular coagulation (DIC). In patients with gastric carcinoma, this association is infrequent. Below we present a case of a 19-year-old female patient with no known pathological history who presented with upper digestive tract bleeding. Upon examination, anemia and thrombocytopenia were documented, with schistocytes in the peripheral blood smear and prolonged coagulation times. Endoscopic studies indicated a lesion in the Borrmann IV gastric body, and the bone marrow biopsy showed the presence of signet ring cells. Because there was no possibility of systemic therapy, the patient died during hospitalization. This case contributes to the medical literature by describing an unusual presentation of a very frequent pathology.


Adenocarcinoma , Carcinoma , Disseminated Intravascular Coagulation , Stomach Neoplasms , Thrombotic Microangiopathies , Female , Humans , Young Adult , Adult , Disseminated Intravascular Coagulation/etiology , Bone Marrow/pathology , Adenocarcinoma/complications , Thrombotic Microangiopathies/complications , Thrombotic Microangiopathies/diagnosis , Carcinoma/complications , Carcinoma/drug therapy , Carcinoma/pathology , Stomach Neoplasms/complications
2.
Int J Surg Pathol ; 30(4): 419-421, 2022 Jun.
Article En | MEDLINE | ID: mdl-34761696

Objective. Reports of heterotopic tissue in the placenta are few and mainly include liver and adrenal cells. We report on adipose tissue found in the placenta. Case report. We present the case of a microscopic finding in a 25-year-old's placenta who suffered from hypertensive disorder in pregnancy. During routine microscopic study, we observed a heterotopic, benign, circumscribed and intervillous nodule of adipose tissue. Conclusion. To our knowledge, there is no other reported case of adipocytes among chorionic villi. Why foreign tissues show up in the placenta remains unknown; however, several new theories offer explanations.


Choristoma , Placenta Diseases , Adipose Tissue , Adult , Female , Humans , Liver , Placenta , Pregnancy
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