Cell Blocks from Ultrasound Guided Fine Needle Aspirates: Diagnostic Yield in a Series of 51 Dermatologic Lesions / Bloques celulares obtenidos de la punción-aspiración con aguja fina ecoguiada: rendimiento diagnóstico en una serie de 51 lesiones dermatológicas

The generation of cell blocks (CB) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated (AU)

La generación de bloques celulares (CBs) obtenidos a partir de punción-aspiración con aguja fina guiada por ultrasonido (USFNAB), es una técnica bien establecida en patología mamaria y tiroidea, pero rara vez se utiliza en dermatología. Revisamos los CBs obtenidos por USFNAB de lesiones cutáneas, que se clasificaron como tumores cutáneos malignos, tumores cutáneos benignos, tumores cutáneos inflamatorios o enfermedades cutáneas por depósito. El rendimiento diagnóstico de cada categoría se comparó con la histopatología. La USFNAB de 51 lesiones cutáneas se procesó en CBs. Hubo concordancia global entre la histopatología y los CBs en el 84,31% de los casos. La concordancia entre histopatología y CBs para lesiones cutáneas benignas, malignas e inflamatorias y por depósito fue del 69,2, 93,7 y 86,3%, respectivamente. La generación de CBs a partir de USFNAB de lesiones cutáneas debe considerarse como parte del arsenal diagnóstico dermatológico. Se necesita más experiencia para comprender mejor para qué tipos de lesiones dermatológicas estaría claramente recomendado (AU)

[Artículo traducido] Bloques celulares obtenidos de la punción-aspiración con aguja fina ecoguiada: rendimiento diagnóstico en una serie de 51 lesiones dermatológicas / Cell Blocks from Ultrasound Guided Fine Needle Aspirates: Diagnostic Yield in a Series of 51 Dermatologic Lesions

La generación de bloques celulares (CBs) obtenidos a partir de punción-aspiración con aguja fina guiada por ultrasonido (USFNAB), es una técnica bien establecida en patología mamaria y tiroidea, pero rara vez se utiliza en dermatología. Revisamos los CBs obtenidos por USFNAB de lesiones cutáneas, que se clasificaron como tumores cutáneos malignos, tumores cutáneos benignos, tumores cutáneos inflamatorios o enfermedades cutáneas por depósito. El rendimiento diagnóstico de cada categoría se comparó con la histopatología. La USFNAB de 51 lesiones cutáneas se procesó en CBs. Hubo concordancia global entre la histopatología y los CBs en el 84,31% de los casos. La concordancia entre histopatología y CBs para lesiones cutáneas benignas, malignas e inflamatorias y por depósito fue del 69,2, 93,7 y 86,3%, respectivamente. La generación de CBs a partir de USFNAB de lesiones cutáneas debe considerarse como parte del arsenal diagnóstico dermatológico. Se necesita más experiencia para comprender mejor para qué tipos de lesiones dermatológicas estaría claramente recomendado (AU)

The generation of cell blocks (CB) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated (AU)

Cell Blocks from Ultrasound Guided Fine Needle Aspirates: Diagnostic Yield in a Series of 51 Dermatologic Lesions.

The generation of cell blocks (CB) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated.

Cell Blocks from Ultrasound Guided Fine Needle Aspirates: Diagnostic Yield in a Series of 51 Dermatologic Lesions. / [Artículo traducido] Bloques celulares obtenidos de la punción-aspiración con aguja fina ecoguiada: rendimiento diagnóstico en una serie de 51 lesiones dermatológicas.

The generation of cell blocks (CBs) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated.

Características clínicas e histológicas del melanoma primario múltiple en una serie de 31 pacientes / Clinical and Histologic Features of Multiple Primary Melanoma in a Series of 31 Patients

INTRODUCCIÓN: Realizamos una revisión de los melanomas múltiples primarios que se han diagnosticado en nuestro servicio a lo largo de los últimos 32 años (1987-2019) con el objetivo de tener mejor caracterizada nuestra población de pacientes con melanoma y poder ofrecerles un seguimiento más estrecho mediante la elaboración de un protocolo de seguimiento personalizado. METODOLOGÍA: Estudio observacional, descriptivo y retrospectivo de los melanomas primarios múltiples diagnosticados en un hospital de tercer nivel entre enero de 1987 y marzo de 2019. Se recogieron las características clínicas, epidemiológicas e histológicas de los melanomas primarios, así como de los subsecuentes melanomas, y se realizó un análisis descriptivo de las mismas. RESULTADOS: Se incluyeron 31 pacientes (15 hombres y 16 mujeres), con una media de edad de 67 años (intervalo: 36-85 años). La mediana de tiempo transcurrido desde el diagnóstico del primer melanoma primario y el del segundo melanoma fue de 2 años (intervalo 0-4 años). La mediana del número de melanomas por paciente fue de 2 (entre 2 y 6). Del total de 31 pacientes, 25 padecieron 2 melanomas (80%), 4 de ellos 3 melanomas (13%), y 2 pacientes presentaron 5 y 6 melanomas primarios, respectivamente. Los segundos melanomas primarios o subsecuentes eran menos invasivos comparados con los primeros. La mediana de índices de Breslow fue de 1mm en los primeros (entre 0,67 y 4 mm) y de 0,5 mm (0,32-2,42 mm) en los segundos. CONCLUSIONES: Los melanomas subsecuentes son más finos que los primeros melanomas diagnosticados. Se encontró un aumento de la frecuencia en los dos últimos años de melanomas múltiples primarios. Estos datos resaltan la importancia del seguimiento estrecho y a largo plazo de estos pacientes

BACKGROUND: We reviewed all cases of multiple primary melanoma diagnosed at our department over a 32-year period (1987-2019) to better characterize this subgroup of patients and develop a tailored protocol to offer them closer follow-up. METHODS: Retrospective, observational, descriptive study of patients diagnosed with multiple primary melanoma at a tertiary care hospital between January 1987 and March 2019. We collected clinical, epidemiologic, and histologic characteristics of primary and subsequent melanomas and performed a descriptive analysis. RESULTS: Thirty-one patients (15 men and 16 women) with a median age of 67 years (range, 36-85 years) were included. Second primary melanomas were diagnosed after a median of 2 years (range, 0-4 years). The median number of melanomas per patient was 2 (range, 2-6). Twenty-three of the 31 patients, 25 had 2 primary melanomas (80%), 4 had 3 melanomas (13%), and 2 patients each had 5 and 6 primary melanomas. Subsequent melanomas were less invasive than the initial primary melanomas. Median Breslow thickness was 1mm (range, 0.67-4 mm) for the first primary melanoma and 0.5mm (range, 0.32-2.42 mm) for subsequent melanomas. CONCLUSIONS: Subsequent melanomas are thinner than primary melanomas. We observed an increase in the number of cases of multiple primary melanoma diagnosed in the last 2 years of our study. Our findings highlight the importance of close, long-term follow-up of patients

Clinical and Histologic Features of Multiple Primary Melanoma in a Series of 31 Patients. / Características clínicas e histológicas del melanoma primario múltiple en una serie de 31 pacientes.

BACKGROUND: We reviewed all cases of multiple primary melanoma diagnosed at our department over a 32-year period (1987-2019) to better characterize this subgroup of patients and develop a tailored protocol to offer them closer follow-up. METHODS: Retrospective, observational, descriptive study of patients diagnosed with multiple primary melanoma at a tertiary care hospital between January 1987 and March 2019. We collected clinical, epidemiologic, and histologic characteristics of primary and subsequent melanomas and performed a descriptive analysis. RESULTS: Thirty-one patients (15 men and 16 women) with a median age of 67years (range, 36-85years) were included. Second primary melanomas were diagnosed after a median of 2years (range, 0-4years). The median number of melanomas per patient was 2 (range, 2-6). Twenty-three of the 31 patients, 25 had 2 primary melanomas (80%), 4 had 3 melanomas (13%), and 2 patients each had 5 and 6 primary melanomas. Subsequent melanomas were less invasive than the initial primary melanomas. Median Breslow thickness was 1mm (range, 0.67-4mm) for the first primary melanoma and 0.5mm (range, 0.32-2.42mm) for subsequent melanomas. CONCLUSIONS: Subsequent melanomas are thinner than primary melanomas. We observed an increase in the number of cases of multiple primary melanoma diagnosed in the last 2years of our study. Our findings highlight the importance of close, long-term follow-up of patients.

Pseudoflujo en tumores anexiales cutáneos / Pseudoflow in Adnexal Skin Tumors

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Lesión subcutánea cervical tras manipulación quiropráctica: papel de la ecografía cutánea / Subcutaneous Neck Lesion After Chiropractic Manipulation: The Role of Ultrasound Skin Imaging

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Análisis de supervivencia, eficacia y seguridad en psoriasis moderada-grave tratada con ustekinumab. Estudio observacional de 69 pacientes en la práctica clínica habitual / An analysis of Drug Survival, Effectiveness, and Safety in Moderate to Severe Psoriasis Treated With Ustekinumab: An Observational Study of 69 Patients in Routine Clinical Practice

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Tumoración frontal que aumenta de tamaño con maniobra de Valsalva / Frontal Tumor that Increased in Size with the Valsalva Maneuver

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