Update: factors influencing heart rate variability-a narrative review.

Objective: Heart rate variability (HRV) is an important non-invasive marker for the assessment of an organism's autonomic physiological regulatory pathways. Lower HRV has been shown to correlate with increased mortality. HRV is influenced by various factors or diseases. The aim of this narrative review is to describe the current state of knowledge on factors influencing HRV and their significance for interpretation. Methods: The narrative review only included reviews, meta-analyses, and cohort studies which were published until 2021. HRV confounders were grouped into four categories (non-influenceable physiological factors, diseases, influenceable lifestyle factors and external factors). Results: The review found that HRV was decreased not only in non-influenceable physiological factors (e.g., age, gender, ethnicity) but also in connection with various number of acute and chronic diseases (e.g., psychiatric diseases, myocardial infarction, heart failure), influenceable lifestyle factors (e.g., alcohol abuse, overweight, physical activity), and external factors (e.g., heat, noise, shift work, harmful- and hazardous substances). Conclusion: In order to improve the quality of HRV studies and to ensure accurate interpretation, it is recommended that confounders be taken into account in future diagnostic measurements or measurements in the workplace (e.g., as part of health promotion measures) in order to counteract data bias.

Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science.

This updated guideline replaces the "Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science" first published in 2014. Based on the older version of the guideline, the authors have reviewed and evaluated the findings on the use of heart rate (HR) and heart rate variability (HRV) that have been published in the meantime and incorporated them into a new version of this guideline.This guideline was developed for application in clinical practice and research purposes in the fields of occupational medicine and occupational science to complement evaluation procedures with respect to exposure and risk assessment at the workplace by the use of objective physiological workload indicators. In addition, HRV is also suitable for assessing the state of health and for monitoring the progress of illnesses and preventive medical measures. It gives an overview of factors influencing the regulation of the HR and HRV at rest and during work. It further illustrates methods for measuring and analyzing these parameters under standardized laboratory and real workload conditions, areas of application as well as the quality control procedures to be followed during the recording and evaluation of HR and HRV.

A Built-In Guidance System to Monitor Vital Signs in Space and on Earth.

INTRODUCTION: Different types of remote expeditions often require an expedition crew to conduct medical emergency assessments without prior medical training. Modern technology offers new devices that support diagnosis with a simple guided user instructions interface. It is not yet clear how quickly medically untrained individuals can acquire the required skills with such a device. This study investigated the time and quality of obtained outcomes, as well as the mental workload when using a vital signs monitor and its guided procedure interface during a simulation of a medical emergency event.METHODS: There were 50 individuals (25 medically inexperienced, 25 medically trained) who participated in this study. In a randomized order subjects measured electrocardiography, noninvasive blood pressure, pulse oximetry, and body temperature. The procedure was repeated after a 20-min break. Completion time, data validity, and mental workload were analyzed.RESULTS: Average times to obtain stable and reliable signals of all recorded vital signs were significantly shorter for both groups during the second attempt and for medically experienced individuals in comparison to medically inexperienced individuals. The number of errors did not change between attempts for both groups. The mental workload was higher during the first attempt in both groups for most vital sign acquisitions.DISCUSSION: Automated devices could be easily and quickly used by members of a given expedition, even if the crew lacks advanced medical training. With relatively little training provided by a built-in guidance system, medically untrained individuals can achieve a basic level of proficiency in reliably obtaining valid vital signs.Huerta R, Kaduk SI, Fatai L, Rusch H, Weber T, Sammito S. A built-in guidance system to monitor vital signs in space and on Earth. Aerosp Med Hum Perform. 2024; 95(3):139-146.

Systematic Literature Review Regarding Heart Rate and Respiratory Rate Measurement by Means of Radar Technology.

The use of radar technology for non-contact measurement of vital parameters is increasingly being examined in scientific studies. Based on a systematic literature search in the PubMed, German National Library, Austrian Library Network (Union Catalog), Swiss National Library and Common Library Network databases, the accuracy of heart rate and/or respiratory rate measurements by means of radar technology was analyzed. In 37% of the included studies on the measurement of the respiratory rate and in 48% of those on the measurement of the heart rate, the maximum deviation was 5%. For a tolerated deviation of 10%, the corresponding percentages were 85% and 87%, respectively. However, the quantitative comparability of the results available in the current literature is very limited due to a variety of variables. The elimination of the problem of confounding variables and the continuation of the tendency to focus on the algorithm applied will continue to constitute a central topic of radar-based vital parameter measurement. Promising fields of application of research can be found in particular in areas that require non-contact measurements. This includes infection events, emergency medicine, disaster situations and major catastrophic incidents.

Fatigue among Air crews on (Ultra)-Long-Range flights - A comparison of subjective fatigue with objective concentration ability.

Introduction: Long duty times are common in the aviation industry, especially with the introduction of ultra long range flights (ULR). This article aims to compare the subjective fatigue assessment and concentration ability of flight crews with objective concentration and alertness tests during (U)LR-flights. Method: The study examined different (U)LR-flights. Before, during and after the flights subjective fatigue and concentration ability of the flight crew was examined with visual analog scale and objective attention and concentration ability with the FAIR-2 test respectively the 3-min Psychomotor Vigilance Test. For statistical analysis we used a repeated ANOVA with a post-hoc-analysis and a Wilcoxon signed-rank test for connected samples. Results: In total 28 crew members were examined. Subjective concentration ability declined and fatigue increased significantly over the course of flights. However, no significant changes were observed in the objective concentration tests performed before and after the flights. Conclusions: The study found that fatigue significantly increased with flight time, particularly during night hours at the window of circadian low of the crews. However, objective concentration performance showed no significant deterioration over time. The study's results were consistent with previous research, except for the finding that objective concentration was still stable. The study also compared the findings to another profession and found similar results regarding the performance of complex tasks after long working hours while experiencing fatigue. Pratical applications: This study helps to understand the effects of ultra long-range flight on fatigue and concentration of the air crew and can help to improve safety issues on such flights.

Management of atrial fibrillation in German military aircrew.

INTRODUCTION: Arrhythmias are one of the most common causes of loss of flying privileges for both military and civilian pilots in the Western World, and atrial fibrillation (AF) is one of the most common arrhythmias worldwide. Aircrew, and particularly pilots, are subject to a unique and exacting working environment, especially in high-performance military aircraft. This manuscript analyzes AF cases in German military aircrew from both a clinical and occupational perspective to point out specific characteristics in this comparatively young, highly selected, and closely monitored group, and to discuss AF management with the aim of a return to flying duties. METHODS: The digital information systems of the German Air Force Centre of Aerospace Medicine (GAFCAM) were searched for aircrew (pilot and non-pilot aircrew from German Air Force, Army, and Navy) with the diagnosis of AF. Evaluation results for underlying disease, AF characteristics, important clinical findings, and occupational decisions were analyzed in the light of current clinical guidelines and aeromedical regulations. RESULTS: In a 34-year period, between March 1989 and January 2023, 42 aircrew with at least one episode of AF were registered, all of them were male. The median age at initial diagnosis was 47 years (min 22 years, max 62 years). The median follow-up period was 5.35 years. 19 of them (45%) were pilots. The breakdown of events and occurrence was found to be: single (23), paroxysmal (16), persistent (2), permanent (1). In 27 aircrew (64%) AF terminated spontaneously. Long-term recurrence prevention was variable with catheter ablations in 8 cases. 36/42 aircrew were returned to flight status with restrictions, while 6/42 were permanently disqualified from flying. CONCLUSION: Management of AF in military aircrew requires a comprehensive approach regarding the flight environment as well as clinical guidance. Aeromedical disposition should be case-by-case based on aeromedical regulations, individual clinical findings, and specific occupational requirements in this challenging field of work.

Performing Advanced Trauma Life Support (ATLS) across Borders: Midterm Follow-Up of the Aeromedical Evacuation after Civilian Bus Accident at Madeira.

On 17 April 2019, a coach with tourists from Germany crashed in Madeira, requiring repatriation by the German Air Force. The Advanced Trauma Life Support (ATLS) concept was the central component of patient care. Data in Madeira were collected through a structured interview. The analysis of the Aeromedical Evacuation was based on intensive care transport records. In Germany, all available medical data sheets were reviewed for data collection. Quality of life (HRQoL) was evaluated by the 12-item Short Form Health Survey (SF-12). Twenty-eight prehospital patients were transported to the Level III Trauma Center in Funchal (Madeira). Five operative procedures were performed. Fifteen patients were eligible for Aeromedical Evacuation (AE). In the second hospital phase in Germany, in total 82 radiological images and 9 operations were performed. Hospital stay lasted 11 days (median, IQR 10-18). Median follow-up (14 of 15 patients) was 16 months (IQR 16-21). Eighty percent (8 out of 10) showed an increased risk for post-traumatic stress disorder (PTSD). Six key findings were identified in this study: divergent injury classification, impact of AE mission on health status, lack of communication, need of PTSD prophylaxis, patient identification, and media coverage. Those findings may improve AE missions in the future, e.g., when required after armed conflicts.

Changes in vital signs, ventilation mode, and catecholamine use during intensive care aeromedical evacuation flights.

Introduction: Especially after (natural) disasters, local health systems are also destroyed or their ability to work is massively restricted. The transport of injured patients is therefore often necessary for further care. Numerous nations keep fixed-wing aircraft with intensive-care capabilities available for secondary transport, but little data on the transport is available to date. Methods: An analysis of all flights with the German Air Force's intensive care fixed-wing-aircraft carried out in the context of humanitarian aid missions since 2002 with a focus on intubated patients was done. Results: A total of 38 patients were transported. Two patients had to be intubated on or during transport. There were significant changes in the necessary positive end-expiratory pressure (PEEP) and the fraction of inspired oxygen. Circulatory parameters did not change. Discussion: Overall, there are no clinically relevant deteriorations due to secondary transport with corresponding air transfers. Due to the hypobaric hypoxic conditions on board of all aircrafts, intubation in clinically borderline patients should be performed electively on the ground before flight.

Cardiovascular risk profiles in German Air Force pilots.

INTRODUCTION: Cardiovascular disease (CVD) is the leading cause of death in western industrial countries and one of the most frequent causes of sudden incapacitation in flight for pilots. There are limited data available on cardiovascular risk profiles of pilots, and especially military pilots. The aim of this study was to assess the prevalence of cardiovascular risk factors (CVRF) in German military pilots. METHODS: The changing prevalence of CVRF in active military pilots was studied using a cross-sectional survey during two distinct periods, 2007-2009 and 2016-2018. Data collected included sex, body mass index (BMI), smoking status, resting blood pressure, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides and glucose. The use of antihypertensive drugs, diagnosis of diabetes mellitus and positive family history of myocardial infarction were also captured. Based on these data, the PROCAM (Prospective Cardiovascular Münster) score was calculated. RESULTS: Data from 5353 flight medical examinations were analysed, 3397 from 2007 to 2009, and 1959 from 2016 to 2018. Between the cohorts, age, BMI, total cholesterol, HDL, LDL, glucose and triglycerides increased significantly. The number of pilots on antihypertensive medication decreased significantly. The PROCAM score increased between cohorts from 18 to 23 points predicting a 10-year risk of an acute coronary event of <1% and 1.3%, respectively. CONCLUSION: The German military pilot population has become older with increased CVRF. CVD will be a future challenge for the German Armed Forces and probably other military forces. However, there was only a mild increase of the PROCAM score over time.

Coronary Artery Disease Management in Military Aircrew.

INTRODUCTION: Coronary artery disease (CAD) is the leading cause of denial or withdrawal of flying privileges for aircrew. Screening for CAD is therefore crucial. The present study analyzed German military aircrew with diagnosed CAD and/or acute coronary syndrome despite close medical monitoring with the intention to further optimize individual outcomes and aeromedical disposition.METHODS: The digital information systems of the German Air Force Centre of Aerospace Medicine were searched for pilots and nonpilot aircrew with CAD and/or myocardial infarction (MI). They were retrospectively analyzed for age at initial diagnosis, body mass index, cardiovascular risk factors, diagnostic procedures, treatment, and aeromedical disposition.RESULTS: Between February 1987 and March 2023, 126 aircrew, 55% pilots and 45% nonpilot aircrew, were identified with CAD and/or MI. An accumulation of two to six risk factors was found in 77% of both groups. Most pilots (54%) received conservative treatment, 44% underwent percutaneous coronary intervention, and 3% coronary artery bypass grafting. In the group of nonpilot aircrew, conservative treatment was performed in 47%, coronary intervention in 37%, and bypass grafting in 16%. A total of 45 pilots (65%) returned to flying duties, albeit 39 (57%) with restrictions. In the group of nonpilot aircrew, 31 (54%) returned to flying duties.DISCUSSION: A small group of aircrew developed CAD over the years, some with severe coronary artery stenoses and MI. Further optimization of individual prognosis and aeromedical disposition should aim at appropriate CAD screening and risk factor elimination. CAD management needs a comprehensive approach regarding military aviation requirements and clinical guidance.Guettler N, Sammito S. Coronary artery disease management in military aircrew. Aerosp Med Hum Perform. 2023; 94(12):917-922.

Return to Flying After Catheter Ablation of Arrhythmic Disorders in Military Aircrew.

INTRODUCTION: Catheter ablation is a widely used and effective treatment option for many tachyarrhythmic disorders. This study analyzes all ablation cases in German military aircrew over a 17-yr period. Recurrence of different arrhythmias and ablation complications were analyzed with an aim of refining specific recommendations for aircrew employment.METHODS: All cases of catheter ablations in pilots and nonpilot aircrew examined at the German Air Force Centre of Aerospace Medicine from 2004 to 2020 were analyzed for sex, age, concomitant diseases, ablated arrhythmias, complications, recurrences, time elapsed from ablation to reablation, number of ablations, and aeromedical disposition, including restrictions in case of a return to flying duties.RESULTS: There were 36 aircrew who underwent catheter ablation; 7 were ablated for 2 or more different arrhythmias; 10 underwent more than one ablation. Ablated arrhythmias included atrioventricular (AV) nodal re-entrant tachycardias, accessory pathways, focal atrial tachycardias, typical and atypical atrial flutter, atrial fibrillation, and premature atrial and ventricular complexes. Recurrence rates differed between the arrhythmias and were lowest in AV re-entrant tachycardias. Complication rates were low.CONCLUSION: In this aircrew cohort, nearly all aircrew were able to return to flying duties following ablation, albeit some with restrictions. Restrictions depended on the underlying arrhythmia, the ablation procedure, and the symptoms prior to ablation. A basic understanding of different arrhythmias, ablation techniques, and long-term success rates is essential for the AME and for the responsible licensing authority. Close cooperation with an electrophysiologist is necessary prior to and after ablation to ensure optimal management of aircrew with arrythmias.Guettler N, Nicol E, Sammito S. Return to flying after catheter ablation of arrhythmic disorders in military aircrew. Aerosp Med Hum Perform. 2022; 93(10):725-733.

Exercise ECG for Screening in Military Aircrew.

INTRODUCTION: The exercise electrocardiogram (ExECG), or stress test, is a widely used screening tool in occupational medicine designed to detect occult coronary artery disease, and assess performance capacity and cardiovascular fitness. In some guidelines, it is recommended for high-risk occupations in which occult disease could possibly endanger public safety. In aviation medicine, however, there is an ongoing debate on the use and periodicity of ExECG for screening of aircrew.METHOD: In the German Armed Forces, aircrew applicants and active-duty aircrew undergo screening ExECG. We analyzed 7646 applicant ExECGs (5871 from pilot and 1775 from nonpilot applicants) and 17,131 ExECGs from 3817 active-duty pilots. All were performed at the German Air Force Centre of Aerospace Medicine (GAFCAM) and analyzed for ECG abnormalities, performance capacity, blood pressure, and heart rate response.RESULTS: Only 15/5871 (0.2%) of pilot applicants required further investigation and none were ultimately disqualified for aircrew duties due to their ExECG results. Of the nonpilot applicants, 22/1775 (1.2%) required further diagnostic work-up due to their ExECG findings, with only 1 ultimately disqualified. From active-duty pilots, 84/17,131 (0.5%) ExECGs revealed findings requiring further investigation, with only 2 pilots ultimately disqualified from flying duties.DISCUSSION: The extremely low yield of ExECG findings requiring further evaluation and/or disqualification for aircrew duties suggest its use is questionable and not cost-effective as a screening tool in this cohort. It may be enough to perform ExECG on clinical indication alone.Guettler N, Nicol ED, Sammito S. Exercise ECG for screening in military aircrew. Aerosp Med Hum Perform. 2022; 93(9):666-672.

Randomised Controlled Study on Measures to Increase Vaccination Rates among German Armed Forces Soldiers.

Vaccination is one of the most effective medical measures for preventing infectious diseases. Even though there are recommendations for specific occupational groups that have an increased risk of infection, e.g., armed forces personnel, there are gaps in the vaccination rates of this personal. We conducted a randomised and controlled cohort study to examine whether a computerised reminder system would increase the vaccination rates of active soldiers over a period of twelve months. A total of 506 soldiers with a mean age of 27.7 ± 6.5 years (experimental group (EG)) and 27.9 ± 6.3 years (control group (CG)) were included in our study. Only 26.2% of the EG and 31.3% of the CG had received the required vaccinations at the beginning of our study. The vaccination rates for influenza (50.5% and 49.1%) and tick-borne encephalitis (57.1% and 60.7%) were particularly low, for measles, mumps, and rubella they were high (94.3% and 97.8%). A highly significant increase (p < 0.001) in vaccination rates was observed for both groups during our study. The results revealed considerable vaccination gaps among German armed forces soldiers. Despite a highly significant increase in vaccination rates during the study, there is still a clear need for action.

The Prevalence of Dietary Supplement Usage in Military Aviators.

BACKGROUND: The prevalence of dietary supplement (DS) and energy drink (ED) usage in military personnel differs from branch to branch and is between 55% and 76% (higher values in special operations forces). Aviators with highly demanding tasks might be especially interested in using dietary supplements. To date, there are only limited data available for this special profession inside the military. METHODS: An internet-based survey was conducted on the prevalence of DS and ED usage, the reasons for their usage and the place of purchase for all wings of the German Armed Forces. RESULTS: Of the 181 pilots who participated in the survey, 34% used DSs and 16% EDs. Usage was linked to sports activities but not to the type of aircraft. DSs were purchased on the internet by 50% of the respondents; mostly protein supplements, magnesium and omega-3fatty acids. Only 42% said they would feel an effect from taking DSs. CONCLUSIONS: Although the present study showed that the prevalence of usage was comparable to that of the civilian population, the sources of supply and the range of the substances taken give cause for concern. This calls for education and information campaigns to make the pilots aware of the possible risks to their health.

Fatigue and Ability to Concentrate in Flight Attendants During Ultra-Long-Range Flights.

Sammito, Stefan, David Cyrol, and Janina Post. Fatigue and ability to concentrate in flight attendants during ultra-long-range flights. High Alt Med Biol. 23:159-164, 2022. Background: Scientific studies on stresses and strains experienced by flight crews in the ultra-long-range (ULR) sector have focused on the group of pilots. Studies on cabin crews are rare. Methods: The subjective fatigue, concentration, and responsiveness of 16 flight attendants were examined during 3 flights (first and third flights were ULR flights) and related to the local time at the home airport. The flight route was Cologne/Bonn (Germany) to Canberra (Australia) (first flight), Tahiti (French Polynesia) (second flight), and back to Cologne/Bonn (third flight). Results: Overall, there was an increase in fatigue (first flight: +36.0% and third flight: +38.5%) as well as reduced responsiveness (-32.5% and -35.5%) and concentration (-30.0% and -33.5%) in the course of the ULR flights. A marked increase in fatigue occurred in particular during night hours measured against the local time at the home airport, especially at the beginning of the third flight. For all parameters, there was consistently no difference between the individual shift groups of flight attendants (p > 0.05). Conclusions: ULR flights cause cabin crew members to become increasingly fatigued due to the length of the flights despite appropriate rest opportunities. The available findings can help to prepare in the best possible way for necessary flight safety through appropriate planning of shift models, especially with regard to the potentially critical takeoff and landing stages. To this end, local times at the home airport must also be taken into account.

Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model.

BACKGROUND: Musculoskeletal injuries (MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during initial training, operational training, and deployment and have a direct negative impact on overall troop readiness. Currently, a systematic overview of all risk factors for MSkIs in the military is not available. METHODS: A systematic literature search was carried out using the PubMed, Ovid/Medline, and Web of Science databases from January 1, 2000 to September 10, 2019. Additionally, a reference list scan was performed (using the "snowball method"). Thereafter, an international, multidisciplinary expert panel scored the level of evidence per risk factor, and a classification of modifiable/non-modifiable was made. RESULTS: In total, 176 original papers and 3 meta-analyses were included in the review. A list of 57 reported potential risk factors was formed. For 21 risk factors, the level of evidence was considered moderate or strong. Based on this literature review and an in-depth analysis, the expert panel developed a model to display the most relevant risk factors identified, introducing the idea of the "order of importance" and including concepts that are modifiable/non-modifiable, as well as extrinsic/intrinsic risk factors. CONCLUSIONS: This is the qualitative systematic review of studies on risk factors for MSkIs in the military that has attempted to be all-inclusive. A total of 57 different potential risk factors were identified, and a new, prioritizing injury model was developed. This model may help us to understand risk factors that can be addressed, and in which order they should be prioritized when planning intervention strategies within military groups.

Electrocardiographic abnormalities in medically screened German military aircrew.

BACKGROUND: A resting electrocardiogram (ECG) is a well-tolerated, non-invasive, and inexpensive test for overt electrical signs of cardiac pathology and is widely used in the screening of aircrew and other high-hazard occupations. Given the low number of pathological results leading to disqualification or restriction however, there is an ongoing debate as to how often screening ECGs should be performed in different age groups. METHODS: We restrospectively analyzed 8275 resting 12-lead ECGs registered between 2007 and 2020 in the German Air Force Centre of Aerospace Medicine. Findings were categorized according to consensus recommendations published by the NATO Working Group on Occupational Cardiology in Military Aircrew, based on ECG screening criteria published for athletes which were used at the time of registration. Age, sex, height, weight, and body mass index of the probands were also captured. Additionally, 4839 pilot and non-pilot aircrew members were analyzed longitudinally over a maximum period of 13.4 years. RESULTS: Out of all the ECGs only 18 revealed findings requiring further investigation, and only one individual was temporarily disqualified because of a ventricular pre-excitation (delta wave) as a sign of an antegrade conducting accessory pathway. The longitudinal analysis of 25,829 ECGs revealed 28 abnormalities requiring further investigation, and only two ECG findings (in probands aged 48.8 and 59.1 years) led to temporary, or permanent disqualification. In a third case, the ECG showed signs of a myocardial infarction, which was already known from the proband's history. CONCLUSIONS: Initial ECG screening for asymptomatic aircrew revealed extremely low numbers of individuals requiring further investigation in our cohort. This would appear to justify an initial screening ECG and follow-up ECGs at certain intervals starting at a certain age, but routine ECG screening of applicants in professions with a higher risk tolerance or frequent, e.g. annual, follow-up ECGs in younger aircrew is not supported by our data because of the minimal yield of ECG findings requiring further investigation.

Analysis of European Air Medical Evacuation Flights of Coronavirus Disease 2019 Patients.

OBJECTIVE: As part of the humanitarian response to the coronavirus disease 2019 (COVID-19) pandemic, the German and French Armed Forces provided air transport for patients from overwhelmed regional hospitals in Italy and France. The objective of this study was to analyze the characteristics of the missions and the medical conditions of COVID-19 patients transported during an air medical evacuation on fixed wing aircraft in March and April 2020. METHOD: This was a retrospective analysis of transport records as well as other documents for 58 COVID-19 patients requiring artificial ventilation. RESULTS: The median age of the transported patients was 61.5 years, and 61% of them had preexisting medical conditions. They had been ventilated for a median of 5 days and experienced the first symptoms 18 days before transport. The patients flown out of France had less days of ventilation before flight, a lower end-tidal carbon dioxide level at the beginning of the flight, and a lower Charlson Comorbidity Index. There were also some differences between the ventilation and the flight level flown by the 2 air forces. CONCLUSION: The intensive care transport of ventilated COVID-19 patients requires highly qualified personnel and appropriate equipment and should be planned appropriately.

Vaccination coverage rates of military personnel worldwide: a systematic review of the literature.

OBJECTIVES: Due to the professionally specific risk of infection in the armed forces, recommendations for vaccination are usually adapted for soldiers and are subject to special regulations. Little data is available on scientifically measured vaccination coverage of soldiers. METHODS: A systematic literature research was carried out in the PubMed database using the search terms "army" or "military" or "Bundeswehr" and "vaccination" or "vaccine". Studies covering the period from 1990 to 2018 that contain statements on vaccination coverage rates of soldiers were identified. Twenty-two out of the initially found 1801 results were used. RESULTS: The studies found were conducted in nine different countries with eight out of the 22 studies originating from the USA. The size of study was between 180 and 32,502 subjects. On average, the vaccination rates determined in the studies were between 26.8 and 94.7%. Hepatitis A coverage was lowest (a minimum of 11.3%) and tetanus vaccination coverage was highest (with a maximum of 94.7%). Vaccination rates decreased with increasing age and coverage tended to be lower for men than for women. The term of service did not have a significant effect on vaccination rates. CONCLUSIONS: On the whole, most studies referred to recruits. They showed high vaccination rates for standard vaccinations and lower vaccination rates for indication and seasonal vaccinations. However, there were also vaccination gaps of temporary-career volunteers. This leads to a considerable effort at the armed forces to complete vaccine protection in case of a short-term operational commitment.