RESUMEN
En cada deporte es importante optimizar peso y composición corporal y la genética y los datos antropométricos pueden influir en rendimiento deportivo y salud, sobre todo en deportistas menores. Este estudio analiza 60 nadadoras artísticas entre 9 y 17 años, divididas en tres grupos de edad: ≤12, 13-15 y 16-17 años. Se realizó un análisis de medidas antropométricas, edad de menarquia, genotipo relacionado con rendimiento (gen ACTN3) y resultados deportivos, con objetivo de relacionar estos parámetros entre sí en los grupos de edad. Las nadadoras de mayor edad mostraron tendencia a portar el genotipo heterocigoto RX de ACTN3. En este estudio, la práctica de este deporte podría tener impacto en índice de masa corporal, pliegue tricipital, peso y edad de menarquia. La mayor prevalencia del genotipo heterocigoto ACTN3 R577X podría ofrecer una ventaja, pero el rendimiento en competición de las nadadoras artísticas tuvo poca relación con sus medidas antropométricas. (AU)
In sport, optimizing weight and body composition is important for performance although an excessive drive for thinness can lead to diminished performance and health problems. This is especially important in the youngest athletes. This study examines 60 national competition-level Spanish artistic swimmers aged 9-17 years. Participants were divided into 3 categories: 12 years and under, 13-15 and 16-17 years. The data analysed were anthropometric measures, menarche age, genotype related to performance (gene ACTN3) and athletic performance. Relationships between athletic performance and anthropometric or genetic data were compared among the three age groups. Swimmers showed a tendency to carry the heterozygous genotype RX of the ACTN3 gene in the older age group. In this study, this sport could have an impact on body mass index, triceps skinfold, weight, menarche age, and selection of one genotype, but the performance in competition of the artistic swimmers had little linking to anthropometric measures. (AU)
Asunto(s)
Humanos , Femenino , Niño , Adolescente , Natación/estadística & datos numéricos , Natación/tendencias , Composición Corporal , Epidemiología Descriptiva , Genética , Rendimiento AtléticoRESUMEN
Introduction: colonic diverticulosis, as diverticulitis, is a frequent disease in different stages of evolution. There is uncertainty about treatment options that are used in secondary peritonitis. The aim of this study is to determine the best treatment option for patients with peritonitis secondary to diverticulitis of the left colon in terms of postoperative morbidity (POM) and mortality, comparing Hartmann's procedure (HP) and resection with primary anastomosis (RPA). Material and Methods: systematic review. Studies in adults with peritonitis secondary to diverticulitis of the left colon treated with HP and RPA published between 1990 and 2011 were analyzed. TRIPDATABSE, IWO, MEDLINE, SciELO and LILACS databases were consulted and search strategies were applied using MeSH and free terms. Selected studies were analyzed using a score of methodological quality (MQ). The following variables were considered: mortality, POM, hospital stay, percentage of bowel transit reconstitution in patients undergoing HP and MQ of primary studies. Results: 26 primary studies were analyzed (47 series). There were no significant differences in the variable mortality (p = 0.0805), but significant difference was observed in POM (incompletely reported) (p = 0.0187). The median of MQ of the studies was 11 points for HP series and 10 for RPA series. Conclusion: the available evidence to determine the best treatment option in terms of mortality and POM in this kind of patients is insufficient. Studies with better level evidence and MQ are needed to clarify the uncertain.
Introducción: la enfermedad diverticular del colon es una entidad frecuente, como también la diverticulitis en sus diferentes estadios de evolución. Existe incertidumbre respecto de las opciones terapéuticas que se utilizan en el tratamiento de la peritonitis diverticular de colon izquierdo (PDCI). El objetivo de este estudio es determinar la mejor opción de tratamiento para pacientes con PDCI entre procedimiento de Hart-mann (PH) y resección con anastomosis primaria (RAP), en términos de mortalidad y morbilidad postoperatoria (MPO). Material y Método: revisión sistemática de la literatura. Se analizaron estudios realizados en adultos con PDCI tratados con PH y RAP, publicados entre 1990 y 2011. Se consultó en las bases de datos TRIPDATABSE, IWO, MEDLINE, SciELO y LILACS, utilizando estrategias de búsqueda con términos MeSH, palabras libres y operadores booleanos. Los estudios seleccionados fueron analizados mediante un escore de calidad metodológica (CM). Se consideraron las variables mortalidad, MPO, estadía hospitalaria, porcentaje de reconstitución de tránsito en pacientes sometidos a PH y CM de los estudios primarios. Resultados: se analizaron 26 estudios primarios (47 series de pacientes). No se encontraron diferencias significativas respecto de la variable mortalidad (p = 0,0805); pero sí en la variable MPO, reportada de forma incompleta (p = 0,0187). La mediana de la CM de los estudios primarios fue de 11 puntos para las series de PH y de 10 para las de RAP. Conclusión: la evidencia disponible no permite determinar la mejor alternativa terapéutica en términos de mortalidad y MPO en este tipo de pacientes. Se requieren estudios de mejor nivel de evidencia y CM para aclarar esta incertidumbre.
Asunto(s)
Humanos , Diverticulitis del Colon/cirugía , Diverticulitis del Colon/complicaciones , Peritonitis/cirugía , Peritonitis/etiología , Anastomosis Quirúrgica , Diverticulitis del Colon/mortalidad , Complicaciones Posoperatorias , Peritonitis/mortalidadRESUMEN
BACKGROUND: CYP2D6 is an important cytochrome P450 enzyme. These enzymes catalyse the oxidative biotransformation of about 25% of clinically important drugs as well as the metabolism of numerous environmental chemical carcinogens. The most frequent null allele of CYP2D6 in European populations, CYP2D6*4, has been studied here in order to elucidate whether a relationship exists between this allele and the risk of developing breast cancer in a Spanish population. MATERIALS AND METHODS: Ninety-six breast cancer Spanish patients and one hundred healthy female volunteers were genotyped for the CYP2D6*4 allele using AmpliChip CYP450 Test technology. RESULTS: Homozygous CYP2D6*4 frequency was significant lower in breast cancer patients than in the control group (OR=0.22, p=0.04). The heterozygous CYP2D6*4 group also displayed lower values in patients than in controls but the difference was not significant (OR=0.698, p=0.28). Therefore, the presence of the CYP2D6*4 allele seems to decrease susceptibility to breast carcinoma in the selected population. CONCLUSIONS: A possible decreased transformation of procarcinogens by CYP2D6*4 poor metabolisers could result in a protective effect against carcinogens (AU)
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Anciano , Neoplasias de la Mama/etiología , Carcinoma Ductal de Mama/etiología , Carcinoma Intraductal no Infiltrante/etiología , Carcinoma Lobular/etiología , Citocromo P-450 CYP2D6/genética , Polimorfismo Genético/genética , Alelos , Estudios de Casos y Controles , ADN/genética , Fenotipo , Reacción en Cadena de la Polimerasa , Factores de Riesgo , España/epidemiología , HeterocigotoRESUMEN
Background: Metabolic control of diabetic pregnant women is assessed using glycated hemoglobin (HbAlc) levels and fasting blood sugar. Another glycated protein, namely fructosamine, can be an indicator of average glucose levels during the last three weeks. Aim: To evaluate plasma fructosamine as an indicator of glycemic control in women with gestational diabetes. Patients and Methods: Prospective cohort study of 41 pregnant women aged 30 to 37 years, with gestational and pre-gestational diabetes. Blood glucose, HbAlc, fructosamine were measured. Newborn weight, and other prenatal and postnatal variables, were used to evaluate the correlation between metabolic control and the presence or absence of macrosomia. Results: The correlation observed between fructosamine and fasting blood glucose (r = 0.627, p < 0.001) was superior to that of HbA1c and blood glucose (r = 0.516, p < 0.001). No association was observed between macrosomia and levels of fructosamine, nor between the other studied variables. Conclusions: Fructosamine levels were not associated with macrosomia, but it could be better for the evaluation of glycemic control in patients with gestational diabetes since it allows short-term monitoring.
Asunto(s)
Adulto , Femenino , Humanos , Embarazo , Glucemia/análisis , Diabetes Gestacional/sangre , Ayuno/sangre , Macrosomía Fetal/diagnóstico , Fructosamina/sangre , Hemoglobina Glucada/análisis , Biomarcadores/sangre , Métodos EpidemiológicosRESUMEN
Background: Two stage hepatectomy takes advantage of the compensatory regeneration of the liver after a first non curative hepatectomy, to achieve a curative excision in a second intervention. Aim: To report an initial experience with two stage hepatectomy. Material and Methods: Out of sixty four patients who underwent hepatectomy in our institution in the presented period, eight met criteria for colorectal primary and bilateral liver metastatic disease, which we report. Results: Eight patients were subjected to a right portal ligation. In four, a simultaneous metastasis excision in the left lobe was performed. Four to eight weeks later, five were subjected to a right hepatectomy. One patient, that had a relapse of a previous hepatectomy and colectomy, was explored, ligated and afterwards subjected to surgery plus radiofrequency. The six patients that were subjected to excisions were followed for 3 to 39 months. One patient died due to massive pulmonary relapse at 18 months, two were operated again and subjected to radiofrequency, without evidence of residual disease. Two patients have no evidence of relapse and one had a relapse in a rib. Conclusions: In our series, two stage hepatectomy among patients with colorectal cancer and liver metastasis, but its long term results must be evaluated.
Introducción: La hepatectomía en dos etapas utiliza la regeneración compensatoria del hígado tras una primera hepatectomía no curativa para lograr una resección curativa en una segunda intervención. Objetivo: Presentar nuestra experiencia inicial aprovechando esta propiedad, en la estrategia de manejo de pacientes previamente declarados irresecables. Material y Método: Entre Marzo de 2006 y Marzo de 2010, fueron tratados 8 casos. Resultados: De 64 pacientes en los que se realizó hepatectomía, 8 de ellos, con enfermedad metastásica bilateral, confinada al hígado, fueron sometidos a ligadura portal del lado derecho; en la mitad se realizó resección simultánea de enfermedad del futuro remanente hepático izquierdo. Cuatro a 8 semanas más tarde, cinco fueron sometidos a hepatectomía derecha extendida o hepatectomía derecha (con segmento IV previamente resecado), y otro que era recurrente de previa hepatectomía central más colectomía, fue explorado, ligado y luego sometido a cirugía combinada con radiofrecuencia (RFA). Con seguimiento promedio para el grupo resecado RO (n = 6) de 18 meses (3-39), una paciente fallece por recurrencia pulmonar masiva a los 18 meses del diagnóstico, dos se someten a tercera cirugía y RFA con intención curativa, sin evidencia actual de enfermedad, dos no presentan recurrencia y una presenta recurrencia costal, sin evidencia de enfermedad intraabdominal. Otros dos están esperando la hepatectomía post resección del primario y ligadura portal. Conclusión: En nuestro medio, la colectomía y hepatectomía en múltiples etapas en pacientes con enfermedad hepática bilateral metastásica de origen colorrectal es una estrategia factible y razonable para lograr una resección con intención curativa.
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Hepatectomía/métodos , Neoplasias Colorrectales/patología , Neoplasias Hepáticas/cirugía , Neoplasias Hepáticas/secundario , Colectomía , Ligadura , Neoplasias Colorrectales/cirugía , Vena Porta/cirugíaRESUMEN
We report a 16-year-old boy, who suffered a right vent ride penetrating injury caused by a sharp blade that evolved to cardiac tampon. He underwent surgery and was discharged four days later. Thirteen days later, a cardiac murmur was found. An echocardiography showed an aorta-right ventricular fistula. Surgical closure was performed through an aortotomy on cardiopulmonary by pass. The control echocardiography showed a small residual fistula, which closed spontaneously three months later.